The effect of ketone body on the transplantation of dopaminergicstem cells

• Project/Area Number: 19790606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Tottori University
• Principal Investigator: IMAMURA Keiko Tottori University, 医学部付属病院, 医員 (90379652)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥1,910,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: ケトン体 / パーキンソン病 / 神経幹細胞 / 幹細胞移植 / ドパミン神経細胞

Research Abstract

パーキンソン病動物モデルにおける神経幹細胞移植では,移植細胞の生着率が低いなど,臨床応用に向けて多くの課題が残されている.我々はケトン体が神経保護作用を有することを報告している.本研究では,ドパミン神経幹細胞の移植へのケトン体の神経保護効果の応用を試みた.

Research Products

• [Journal Article] Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity. (2008)
  • Author(s): Imamura K,Takeshima T,Nakaso K,Ito S,Nakashima K
  • Journal Title: Neurosci Lett 440(2) Pages: 97-102
  • Peer Reviewed
• [Journal Article] Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity (2008)
  • Author(s): K Imamura, T Takeshima, K Nakaso, S Ito, K Nakashima
  • Journal Title: Neuroscience Letters 440 Pages: 97-102
  • Peer Reviewed
• [Journal Article] Homocysteine is toxic for dopaminergic neurons in primary mesencephalic culture (2007)
  • Author(s): K. Imamura, et. al.
  • Journal Title: NeuroReport 18 Pages: 1319-1322
  • Peer Reviewed
• [Presentation] Pramipexole has astrocyte-mediated protective effects against lactacystin toxicity (2008)
  • Author(s): K Imamura, T Takeshima, K Nakaso, S Ito, K Nakashima
  • Organizer: Society for Neuroscience 2008
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-18
• [Presentation] Pramipexole has astrocyte-mediated protective effects against lactacystin toxicity. (2008)
  • Author(s): Imamura K,Takeshima T,Nakaso K,Ito S,Nakashima K
  • Organizer: Society for Neuroscience
• [Presentation] Pramipexole protects dopaminergic neurons from lactacystin-induced cell death in rat primary mesencephalic culture (2007)
  • Author(s): K. Imamura, et. al.
  • Organizer: Neuroscience 2007, the Society for Neuroscience's 37th annual meething
  • Place of Presentation: San Diego, USA
  • Year and Date: 2007-11-04