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Immunological evaluation and prediction of the effectiveness of interferon therapy for the Japanese multiple sclerosis patients

Research Project

Project/Area Number 19790622
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionTokyo Metropolitan Organization for Medical Research

Principal Investigator

WARABI Yoko  Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員 (30399464)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥5,901,294 (Direct Cost: ¥4,931,765、Indirect Cost: ¥969,529)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,121,294 (Direct Cost: ¥1,631,765、Indirect Cost: ¥489,529)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords多発性硬化症 / インターフェロン / 視神経脊髄炎 / 神経科学 / 免疫学 / 脳神経疾患 / neuromyelitis optica / 二次性進行型 / 抗AQP4抗体 / Foxp3
Research Abstract

(1) Secondary progressive multiple sclerosis (SPMS) had a normal function of the regulatory T cells, therefore SPMS had a small number of clonally expanded pathogenic T cells. Neuromyelitis optica expressed results exactly the opposite of SPMS. Japanese multiple sclerosis patients must choice the appropriate therapy according to their classified type.
(2) Early interferon therapy for the Japanese multiple sclerosis patients suppresses the number of relapse and the MRI lesions. Moreover, it effect to sustain the quality of life for the patients.
(3) Because the secondary progressive neuromyelitis optica patients reveal the inflammation and demyelination, they must not be treated with interferon.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Role of IL-1 and potential therapies in multiple sclerosis2007

    • Author(s)
      Yoko Warabi
    • Journal Title

      Drug Discovery Today: Therapeutic Strategies Vol.4、No.1

      Pages: 19-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of IL-1 and potential therapies in multiple sclerosis2007

    • Author(s)
      蕨 陽子
    • Journal Title

      Drug Discovery Today: Therapeutic Strategies Vol.4 (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 視神経脊髄炎における二次性進行型多発性硬化症に類似した大脳萎縮の病態の検討2010

    • Author(s)
      蕨陽子、松原四郎、高橋利幸
    • Organizer
      第22回日本神経免疫学会学術集会
    • Place of Presentation
      日経ホール(東京都)
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 多発性硬化症が強く疑われる患者に対するインターフェロン療法早期導入の意義2009

    • Author(s)
      蕨陽子、沖山亮一、松原四郎
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 多発性硬化症確定診断前のインターフェロン療法早期導入の意義2009

    • Author(s)
      蕨陽子、松原四郎
    • Organizer
      第21回日本神経免疫学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2009-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 多発性硬化症確定診断前のインターフェロン療法早期導入の意義2009

    • Author(s)
      蕨 陽子
    • Organizer
      第21回日本神経免疫学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 重度の視神経炎と脊髄炎を伴う多発性硬化症に対するインターフェロン療法の検討2007

    • Author(s)
      蕨陽子、松本陽、林秀明
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2007-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 重度の視神経炎と脊髄炎を伴う多発性硬化症に対するインターフェロン療法の検討2007

    • Author(s)
      蕨陽子、松本陽、林秀明
    • Organizer
      第48回日本神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-05-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 多発性硬化症のFoxp3遺伝子発現の病型による比較解析2007

    • Author(s)
      蕨陽子、林秀明、松本陽
    • Organizer
      第19回日本神経免疫学会学術集会
    • Place of Presentation
      金沢市文化ホール(石川県)
    • Year and Date
      2007-04-12
    • Related Report
      2009 Final Research Report
  • [Presentation] 多発性硬化症のFoxp3遺伝子発現の病型による比較解析2007

    • Author(s)
      蕨陽子、林秀明、松本陽
    • Organizer
      第19回日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2022-01-20  

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