The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma
Project/Area Number |
19790643
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Kurume University |
Principal Investigator |
KAWAGUCHI Takumi Kurume University, 医学部, 講師 (00320177)
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Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 糖尿病学 / 肝細胞癌 / インスリン抵抗性 / tuberin / mTOR / 細胞増殖 / インスリン情報伝達経路 / HOMA-IR / 2型糖尿病 / インスリン / mammalian target of rapamycin / insulin receptor substrate 1 / Akt / 結節性硬化症 |
Research Abstract |
Hyperinsulinemia is frequently seen in patients with hepatocellularcarcinoma (HCC). Since insulin is a growth-promoting hormone, hyperinsulinemia may beinvolved in the development of HCC. In this study, we reveled that insulin may associate with the development of HCC though activation of intracellular molecules related to cell proliferation.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.2010
Author(s)
Kawaguchi T, Yamagishi S, Itou M, Okuda K, Sumie S, Kuromatsu R, Sakata M, Abe M, Taniguchi E, Koga H, Harada M, Ueno T, Sata M.
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Journal Title
Am J Pathol. 176
Pages: 168-76
Related Report
Peer Reviewed
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[Journal Article] Supplement improves nutrition and stresses caused by examination-associated fasting in patients with liver cirrhosis.2008
Author(s)
Kawaguchi T, Taniguchi E, Itou M, Mutou M, Ibi R, Shiraishi S, Okada T, Uchida Y, Otsuka M, Tonan T, Fujimoto K, Oriishi T, Tanaka S, Takakura M, Sata M
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Journal Title
Hepatol Res. 38
Pages: 1178-85
NAID
Related Report
Peer Reviewed
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[Journal Article] Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular carcinoma or esophageal varices.2008
Author(s)
Kawaguchi T, Taniguchi E, Itou M, Ibi R, Okada T, Mutou M, Shiraishi S, Uchida Y, Otsuka M, Umeki Y, Oriishi T, Hayabuchi H, Tanaka S, Takakura M, Sata M
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Journal Title
Int J Mol Med. 22
Pages: 589-94
Related Report
Peer Reviewed
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