Identification of therapeutic targets for adult T-cell leukemia
Project/Area Number |
19790665
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Hematology
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Research Institution | Kyoto University |
Principal Investigator |
HISHIZAWA Masakatsu Kyoto University, 医学研究科・特定病院, 助教 (90444455)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
Keywords | 血液内科学 / 成人T細胞白血病 |
Research Abstract |
成人T細胞白血病(ATL)に対する腫瘍特異的治療法の開発のため、SEREX法にて候補遺伝子のスクリーニングをおこない、その中でも有力であったserine-arginine protein kinase 1 (SRPK1)の解析を中心におこなった。siRNAによるノックダウンではATL細胞株のSRPK1は、効率よくmRNAや蛋白の発現は抑制され、これを用いてアポトーシスや細胞増殖、抗癌剤耐性との関連などを検討した。
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.2009
Author(s)
Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T, Kannagi M.
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Journal Title
Cancer Science Mar;100(3)
Pages: 481-9
NAID
Related Report
Peer Reviewed
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[Journal Article] PD-1.PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma2008
Author(s)
Yamamoto Ryo, Nishikori Momoko, Kitawaki Toshio, Sakai Tomomi, Hishizawa Masakatsu, Tashima Masaharu, Kondo Tadakazu, Ohmori Katsuyuki, Kurata Masayuki, Hayashi Takamasa , and Uchiyama Takashi
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Journal Title
Blood 111(6)
Pages: 3220-3224
Related Report
Peer Reviewed
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