Identification of leukemic stem cells

• Project/Area Number: 19790669
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Kyushu University
• Principal Investigator: KAMEZAKI Kenjirou Kyushu University, 大学病院, 助教 (70380433)
• Research Collaborator: MIYAMOTO Toshihiro 九州大学, 大学病院, 講師 (70343324) ; AKASHI Koichi 九州大学, 大学院・医学研究院, 教授 (80380385)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: 白血病 / 幹細胞 / 分化 / 自己複製

Research Abstract

急性骨髄性白血病幹細胞は正常造血幹細胞とはFlt3hiThy-1-c-KitloIL-3Rhiによる表面抗原の差異で識別可能である。また、急性白血病の発症には、PU.1やC/EBPαの発現低下に見られる転写因子のシグナル異常、Bmi-1とMCL-1の過剰発現などの遺伝子異常により、分化の阻害、細胞生存の強化、増殖能の強化など複数のステップを経て、白血病発症へ導かれることが明らかとなった。

Research Products

• [Journal Article] Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia (2009)
  • Author(s): Shima T, Kamezaki K, Miyamoto T, AkashiK, et al
  • Journal Title: Transpl Infect Dis 11(1) Pages: 75-7
  • Peer Reviewed
• [Journal Article] Disseminated tuberculosis following second unrelated cord blood tran splantation for acute myelogenous leukemia (2009)
  • Author(s): Shima T, Kamezaki K, et.al.
  • Journal Title: Transpl Infect Dis 11 Pages: 75-77
  • Peer Reviewed
• [Journal Article] Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9 (2008)
  • Author(s): Aoki T, Miyamoto T, Kamezaki K, Akashi K, et al
  • Journal Title: Int J Hematol 88(5) Pages: 571-4
  • NAID: 10023971414
  • Peer Reviewed
• [Journal Article] Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient (2008)
  • Author(s): Shima T, Kamezaki K, et.al.
  • Journal Title: Int J Hematol 88 Pages: 336-340
  • NAID: 10023970500
  • Peer Reviewed
• [Journal Article] Additional acquisition of t(1 ; 21)(p32 ; q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9 (2008)
  • Author(s): Aoki T, Kamezaki K, et.al.
  • Journal Title: Int J Hematol 88 Pages: 571-574
  • Peer Reviewed
• [Journal Article] Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence (2007)
  • Author(s): Shide K, Shimoda K, Kamezaki K, et al
  • Journal Title: Leuk Res 31(8) Pages: 1077-84
  • Peer Reviewed
• [Journal Article] Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma (2007)
  • Author(s): Kamezaki K, Miyamoto T, et al
  • Journal Title: Bone Marrow Transplant 39(9) Pages: 523-7
  • Peer Reviewed
• [Journal Article] The effect of anabolic steroids on anemia in myelofibrosis with myeloid metaplasia : retrospective analysis of 39 patients in Japan (2007)
  • Author(s): Shimoda K, Kamezaki K, et al
  • Journal Title: Int J Hematol 85(4) Pages: 338-43
  • Peer Reviewed
• [Journal Article] Chronic thrombopoietin overexpression induces mesangioproliferative glomerulopathy in mice (2007)
  • Author(s): Shimoda HK, Kamezaki K, et al
  • Journal Title: Am J Hematol 82(9) Pages: 802-6
  • Peer Reviewed
• [Journal Article] Marked improvement of cardiac function early after non-myeloablative BMT in a heavily transfused patient with severe aplastic anemia and heart failure (2007)
  • Author(s): Kunisaki Y, Miyamoto T, Kamezaki K, et al
  • Journal Title: Bone Marrow Transplant 40(6) Pages: 593-5
  • Peer Reviewed
• [Journal Article] Toxoplasmosis encephalitis following severe graft-vs-host disease after allogeneic hematopoietic stem cell transplantation : 17 yr experience in Fukuoka BMT group (2007)
  • Author(s): Matsuo Y, Miyamoto T, Kamezaki K, et al
  • Journal Title: Eur J Haematol 79(4) Pages: 317-21
  • Peer Reviewed
• [Journal Article] Collection of mobilized peripheral blood stem cells from a donor with severe iron deficient anemia (2007)
  • Author(s): Kamezaki K, Miyamoto T, Akashi K, et al
  • Journal Title: J ClinApher 22(5) Pages: 292-4
  • Peer Reviewed
• [Journal Article] Successful treatment of myelodysplastic syndrome-related intestinal Behcet's disease by up-front cord blood transplantation (2007)
  • Author(s): Nonami A, Kamezaki K, Miyamoto T, et al
  • Journal Title: Intern Med 46(20) Pages: 1753-6
  • Peer Reviewed
• [Journal Article] Successful treatment of primary plasma cell leukaemia by allogeneic stem cell transplantation from haploidentical sibling (2007)
  • Author(s): Nonami A, Miyamoto T, Kamezaki K, et al
  • Journal Title: Jpn J Clin Oncol 37(12) Pages: 969-72
  • Peer Reviewed
• [Journal Article] Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation (2007)
  • Author(s): Nonami A, Kamezaki K, Miyamoto T, et al
  • Journal Title: Int J Hematol 85(3) Pages: 264-66
  • NAID: 10019489072
• [Journal Article] Successful treatment of parainfluenza virus 3 pneumonia with oral ribavirin and methylprednisolone in a bone marrow transplant recipient (2007)
  • Author(s): Shima T, Kamezaki K, Miyamoto T, Akashi K, et al
  • Journal Title: Int J Hematol 88(3) Pages: 336-40
  • NAID: 10023970500
  • Peer Reviewed
• [Journal Article] [POEMS syndrome: monoclonal plasma cell disorder with Polyneuropathy] (2007)
  • Author(s): Kamezaki, K, Nagafuji, K.
  • Journal Title: 日本臨床 12 Pages: 2235-2237
  • NAID: 40015721743
  • Peer Reviewed
• [Journal Article] Collection of mobilized peripheal blood stem cells from a donor with severe iron deficient anemia. (2007)
  • Author(s): Kamezaki, K, Miyamoto, T, Henzan, T, Numata, A, Iwasaki, H, Nagafuji, K, Harada, M, Teshima, T, Akashi, K.
  • Journal Title: Journal of clinical Apheresis 5 Pages: 292-294
  • Peer Reviewed
• [Journal Article] Rituximab does not compromise the mobilization and engraftment of autologous peripheral blood stem cells in diffuse-large B-cell lymphoma. (2007)
  • Author(s): Kamezaki, K, Kikushige, Y, Numata, A, Miyamoto, T, Takase, K, Henzan, H, Aoki, K, Kato, K, Nonami, A, Kamimura, T, Arima, F, Takenaka, K, Harada, N, Fukuda, T, Hayashi, S, Ohno, Y, Eto, T, Harada, M, Nagafuji, K.
  • Journal Title: Bon Marrow Transplantation 9 Pages: 523-527
  • Peer Reviewed
• [Presentation] Biphenotypic acute leukemia 8例に対する後方視的解析 (2008)
  • Author(s): 河野健太郎、亀崎健次郎、宮本敏浩、その他
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 同種造血幹細胞移植後サイトメガロウイルス再活性化に対する経口バルガンシクロビルによる早期治療の有効性 (2008)
  • Author(s): 竹中克斗、亀崎健次郎、その他
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
• [Presentation] 自己末梢血幹細胞移植後の再発に対してRISTを施行した悪性リンパ腫の検討 (2007)
  • Author(s): 亀崎健次郎、宮本敏浩、その他
  • Organizer: 第29回日本造血細胞移植学会総会
  • Place of Presentation: 福岡
• [Presentation] 福岡BMTグループにおける臍帯血移植の解析 (2007)
  • Author(s): 亀崎健次郎、その他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] 自家末梢血幹細胞移植におけるRituximabの幹細胞動員、生着および移植後好中球減少に及ぼす影響 (2007)
  • Author(s): 宮本敏浩、亀崎健次郎、その他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] 末梢性T細胞性リンパ腫に対する自己末梢血幹細胞移植の後方視的解析 (2007)
  • Author(s): 沼田晃彦、亀崎健次郎、宮本敏浩、その他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Presentation] 同種移植後の再発性急性骨髄性白血病に対してgemtuzumab ozogamicin を分割投与、再移植を行った2例の検討 (2007)
  • Author(s): 高嶋秀一郎、亀崎健次郎、宮本敏浩、その他
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
• [Book] 多発性骨髄腫神経病変 (2007)
  • Author(s): 亀崎健次郎、長藤宏司
  • Publisher: 日本臨床
• [Remarks]
  • URL: http://www.1nai.med.kyushu-u.ac.jp/