Treatment of Acute GVHD using MSCs in Mouse BMT Model.

• Project/Area Number: 19790675
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: SATO Kazuya Jichi Medical University, 医学部, 病院助教 (60382917)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 血液免疫学 / 間葉系幹細胞 / 免疫制御 / GVHD

Research Abstract

マウス骨髄移植モデルでは、間葉系幹細胞によるGVHDの治療効果は確認できなかった。但し、マウス由来間葉系幹細胞はin vitroにおいてはヒトと同様の免疫抑制効果を示しており、何らかの生物学的特性に違いがある可能性が示された。間葉系幹細胞の免疫抑制効果と細胞外マトリックスとの相互関係には非常に興味深いデータが得られたが、エンドトキシンの混入がヒアルロン酸の免疫修飾効果の評価に影響していることが示唆された。

Research Products

• [Journal Article] 間葉系幹細胞によるGVHD制御 (2009)
  • Author(s): 佐藤一也、尾崎勝俊
  • Journal Title: 血液・腫瘍科 58巻 Pages: 371-375
  • NAID: 40019064551
• [Journal Article] 間葉系幹細胞によるGVHD治療の現状 (2008)
  • Author(s): 佐藤一也、尾崎勝俊
  • Journal Title: Annual Review Pages: 36-41
• [Journal Article] Cell and gene therapy using mesenchymal stem cells (MSCs). (2008)
  • Author(s): Ozawa K, Sato K, Oh I, Ozaki K, Uchibori R, Ito T, Okada T, Urabe M, Mizukami, and Kume A
  • Journal Title: J Autoimmun. 30(3) Pages: 121-127
  • Peer Reviewed
• [Journal Article] Cell and Gene Therapy using Mesenchymal Stem Cells (MSCs) (2008)
  • Author(s): Ozawa K, Sato K, Oh I, Ozaki K, U chibori R, Obara Y, Kikuchi Y, Ito T, Okada T, Urabe M, Mizukami H, Kume A
  • Journal Title: J Autoimmun 30(3) Pages: 121-127
  • Peer Reviewed
• [Journal Article] Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. (2008)
  • Author(s): Sato K, Ozaki K, Oh I, Meguro A, Hatanaka K, Nagai T, Muroi K, Ozawa K.
  • Journal Title: Blood 109(1) Pages: 228-234
  • Peer Reviewed
• [Journal Article] Interferon-gamma and NF-kappaB mediate nitric oxide production by mesenchymal stromal cells. (2008)
  • Author(s): Oh I, Ozaki K, Sato K, Meguro A, Tatara R, Hatanaka K, Nagai T, Muroi K, Ozawa K.
  • Journal Title: Biochem Biophys Res Commun. 9(1) Pages: 956-962
  • Peer Reviewed
• [Journal Article] Mechanisms of immunomodulation by mesenchymal stem cells. (2007)
  • Author(s): Ozaki K, Sato K, Oh I, Meguro A, Tatara R, Muroi K, Ozawa K.
  • Journal Title: Int J Hematol 86(1) Pages: 5-7
  • NAID: 10018515331
  • Peer Reviewed
• [Presentation] Hyaluronidase and IFN-{gamma} from Activated T-Cells Are Key Mediators To Induce Immunosuppressive Activity of Mesenchymal Stem Cells (2007)
  • Author(s): Sato K, Ozaki K, Oh I, Matsu H, Tatara R, Meguro A, Hatanaka K, Nagai T, Muroi K, and Ozawa K.
  • Organizer: Cells.49th ASH Annual Meeting and Exposition
  • Place of Presentation: Georgia
  • Year and Date: 2007-12-10
• [Presentation] Hyaluronidase and IFN- from Activated T-Cells Are Key Mediators To Induce Immunosuppressive Activity of Mesenchymal Stem Cells (2007)
  • Author(s): 佐藤 一也
  • Organizer: 第49回米国血液学会総会
  • Place of Presentation: Atlanta
  • Year and Date: 2007-12-10
• [Presentation] 間葉系幹細胞の免疫抑制作用におけるヒアルロン酸の役割 (2007)
  • Author(s): 佐藤 一也
  • Organizer: 第69回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-12