Analysis of clinical feature and molecular pathogenesis of multiple myeloma with the gain of chromosome arm 1q21
| Project/Area Number |
19790677
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
HANAMYRA Ichiro Aichi Medical University, 医学部, 講師 (70440740)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NITTA Masakazu 愛知医科大学, 医学部, 教授 (70128669)
IIDA Shinsuke 名古屋市立大学, 医学部, 准教授 (50295614)
TANIWAKI Masafumi 京都府立医科大学, 医学部, 教授 (80163640)
|
|---|
| Research Collaborator |
GOTO Mayuko
JOHN Shaughnessy
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
|
|---|
| Keywords | 癌 / 多発性骨髄腫 / 1q21 / 染色体転座 / FISH / Iq21 / 1番染色体 / NIK / NF-κB |
|---|
| Research Abstract |
ヒト骨髄腫細胞株を用いた検討では、染色体1q21領域の増加/増幅の多くは1番染色体そのものまたは長腕の増多に伴って起きたものであり、jumping/tandem translocationといった複雑な転座様式をとったものは約30%であった。未治療MM例とは異なり細胞株においては1q21の増加の有無や増幅様式の差と、13q14欠失、17p13欠失、Ig領域との染色体転座で脱制御されるCCND1やFGFR3、c-MAF、MAFBなどとの間に有意な相関は認めなかった。このことは、細胞株は進行期の病変から樹立されることが多いためと思われるが、MMにおいて1番染色体長腕その中でも特に1q21は特異な領域であることが改めて示唆された。
|
Report
(3 results)
Research Products
(33 results)
-
[Journal Article] Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factor2009
Author(s)
Imai N, Miwa H, Shikami M, Suganuma K, Gotoh M, Hiramatsu A, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Shitara K, Shibuya M, Nitta M.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.2007
Author(s)
Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, Dave S, Hurt EM, Tan B, Zhao H, Stephens O, Santra M, Williams DR, Dang L, Barlogie B, Shaughnessy JD Jr, Kuehl WM, Staudt LM.
-
Journal Title
Cancer Cell. 12(2)
Pages: 115-130
Related Report
Peer Reviewed
-
[Journal Article] A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1.2007
Author(s)
Shaughnessy JD Jr, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B.
-
Journal Title
Blood. 109(6)
Pages: 2276-2284
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Energy Metabolism of Leukemia Cells : Glycolysis Vs. Oxidative Phosphorylation2008
Author(s)
Hiroshi Miwa, Kazuto Suganuma, Masato Shikami, Norikazu Imai, Mayuko Sakai, Akihito Hiramatsu, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta
Organizer
第50回アメリカ血液学会総会
Place of Presentation
米国サンフランシスコ
Related Report
-
-
-
-
-
-
-
-
-
