Array CGH analytics and gene expression analytics revealed distinct subgroups in Peripheral T cell lymphomas

• Project/Area Number: 19790678
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: NAKAGAWA Masao Aichi Cancer Center Research Institute, 遺伝子医療研究部, 主任研究員 (80435859)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 末梢性T細胞リンパ腫 / 分類不能型 / 成人T細胞性白血病リンパ腫 / アレイCGH / 末梢性T細胞リンパ腫・分類不能型

Research Abstract

末梢性T細胞リンパ腫(PTCL)の中で、明確な疾患名に診断できない症例は末梢性T細胞リンパ腫・分類不能型(PTCL-U)として扱われる。PTCL-Uは未知の疾患が混在していると考えられるが、明確な報告はなかった。本研究ではPTCL-U51症例にアレイCGH法によるゲノム異常解析を行い、ゲノム異常様式・予後・病理像すべてに相関する二つの疾患群に分類できることをはじめて明らかにした。また二つのうち片方の疾患群は、別のPTCLである成人T細胞性白血病リンパ腫・リンパ腫型とよく似た均質な一群であることも明らかにした。

Research Products

• [Journal Article] Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma. (2009)
  • Author(s): Nakagawa M, (他8名, 1番目)
  • Journal Title: Clin. Cancer Res. 15 Pages: 30-38
  • Peer Reviewed
• [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis. (2009)
  • Author(s): Takeuchi I, Tagawa H, Tsujikawa A, Nakagawa M, et al. (他3名, 4番目)
  • Journal Title: Haematologica 94 Pages: 61-9
  • Peer Reviewed
• [Journal Article] Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma. (2009)
  • Author(s): Masao Nakagawa
  • Journal Title: Clinical Cancer Research 15 Pages: 30-38
  • Peer Reviewed
• [Journal Article] The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis. (2009)
  • Author(s): Ichiro Takeuchi
  • Journal Title: Haematologica 94 Pages: 61-69
  • Peer Reviewed
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma. (2008)
  • Author(s): Honma K, Tsuzuki S, Nakagawa M, et al. (他6名, 3番目)
  • Journal Title: Genes Chrom. Cancer. 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma (2008)
  • Author(s): Keiichiro Honma
  • Journal Title: Genes Chromosomes Cancer 47 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(q21;q21) negative gastric MALT lymphomas. (2007)
  • Author(s): Fukuhara N, Nakamura T, Nakagawa M, Tagawa H, Takeuchi I, Yatabe Y, Morishima Y, Nakamura S and Seto M. et al. (他6名, 3番目)
  • Journal Title: Genes Chrom. Cancer. 46 Pages: 784-790
  • Peer Reviewed
• [Journal Article] Chromosomal imbalances are associated with outcome of Helicobacter pylori eradication in t(11;18)(g21;q21)negative gastric mucosa-associated lymphoid tissue lymphomas (2007)
  • Author(s): Noriko Fukuhara
  • Journal Title: Genes Chromosomes Cancer 46 Pages: 784-90
  • Peer Reviewed
• [Presentation] A part of acute-type ATLL cases has genomic imbalance in common with Lymphoma-type ATLL (2008)
  • Author(s): 中川雅夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] A Part of Acute-type ATLL Cases Has Genomic Imbalance in Common With Lymphoma-type ATLL (2008)
  • Author(s): Masao Nakagawa
  • Organizer: The American Society of Hematology 50th Annual Meeting and Exposition
  • Place of Presentation: San Francisco, USA
• [Presentation] アレイCGH解析によるPTCL-U再分類の可能性 (2007)
  • Author(s): 中川雅夫
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-11
• [Presentation] アレイCGH解析によるPTCL-U再分類の可能性 (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第69回日本血液学会総会・第49回日本臨床血液学会総
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-11
• [Presentation] Comparison of PTCL-U and lymphoma-type ATLL in terms of genomic imbalance by using array CGH analysis (2007)
  • Author(s): 中川雅夫
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Comparison of PTCL-U and lymphoma-type ATLL in tems of genomic imbalance by using array CGH analysis (2007)
  • Author(s): 中川 雅夫
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
• [Presentation] Array CGH analysis for PTCL-U revealed a distinct subgroup with pathological and clinical relevance (2007)
  • Author(s): Masao Nakagawa
  • Organizer: The American Society of Hematology 49th Annual Meeting and Exposition
  • Place of Presentation: Altanta, USA
• [Presentation] Array CGH analysis for PTCL-U revealed a distinct subgroup with pathological and clinical relevance (2007)
  • Author(s): Masao Nakagawa
  • Organizer: The American Society of Hematology 49th Annual Meeting and Exposition
  • Place of Presentation: Altanta,USA