Functional analysis and gene profiling of a macrophage subset unique to rheumatoid arthritis synovium

• Project/Area Number: 19790690
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kagoshima University
• Principal Investigator: TANAKA Masashi Kagoshima University, 大学院・医歯学総合研究科, 助教 (60381167)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,730,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥630,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: リウマチ学 / 慢性炎症 / マクロファージ / 自己免疫疾患 / 滑膜A細胞 / 骨破壊 / 抗原提示 / 免疫学 / リウマチ / マイクロアレイ / 細胞・組織 / 炎症 / 貪食

Research Abstract

関節リウマチ(RA)は関節の変形と破壊をもたらす慢性炎症性疾患である。2つの補体レセプター、Z39IgとCD11cを共に発現する滑膜A細胞(Z39Ig+CD11c+細胞)はRA滑膜に特徴的に出現する。本研究により、当該細胞は、破骨細胞に分化しやすいこと、マクロファージの新規サブセットであること、抗原提示分子を強発現していることを明らかにした。したがって、当該細胞は、高い破骨細胞分化能及び抗原提示能を介してRA病態に関わる可能性が明らかとなった。

Research Products

• [Journal Article] Expansion of a unique macrophage subset in rheumatoid arthritis synovial lining layer (2008)
  • Author(s): Tanaka M, Nagai T, Tsuneyoshi Y, Sunahara N, Matsuda T, Nakamura T, Tsuyama S, Hasui K, FitzGerald O, Matsuyama T
  • Journal Title: Clin Exp Immunol. 154(1) Pages: 38-47
  • Peer Reviewed
• [Journal Article] The 3G5 antigen is expressed in dermal mast cells but not pericytes (2008)
  • Author(s): Gushi A, Tanaka M, Tsuyama S, Nagai T, Kanzaki T, Kanekura T, Matsuyama T.
  • Journal Title: J Cutan Pathol 35(3) Pages: 278-284
  • Peer Reviewed
• [Journal Article] Analysis of Z39Ig+CD11c+ macrophages in inflammatory arthritis synovium (2008)
  • Author(s): Tanaka M, Nagai T, Nishimura T, Tsuneyoshi Y, Sunahara N, Matsuda T, Nakamura T, Tsukano M, Matsuyama T
  • Journal Title: Mod Rheumatol 18(S) Pages: 125-125
• [Journal Article] Limited distribution of folate-receptor beta expressing inflammatory macrophages in murine tissues (2008)
  • Author(s): Nagai T, Tanaka M, Matsuyama T.
  • Journal Title: Mod Rheumatol 18(S)
• [Journal Article] Identification and characterization of the Lubricin-HA complex in synovial fluids of rheumatoid arthritis and osteoarthritis patients (2008)
  • Author(s): Tsuneyoshi Y, Nagai T, Ijiri K, Komiya S, Sunahara N, Matsuda T, Tanaka M, Matsuyama T.
  • Journal Title: Mod Rheumatol 18(S)
• [Journal Article] Expansion of a unique macrophage subset in rheumatoid arthritis svnovial lining laver (2008)
  • Author(s): Tanaka M, et.al.
  • Journal Title: Clin Exp Immunol 154 Pages: 38-47
  • Peer Reviewed
• [Journal Article] The 3G5 antigen is expressed in dermal mast but not pericytes (2008)
  • Author(s): Akira Gushi, Masashi Tanaka, et. al.
  • Journal Title: Journal of Cutaneous Pathology 35 Pages: 278-284
  • Peer Reviewed
• [Journal Article] Analysis of Z39Ig+CD11c+macrophages in inflammatory arthritis synovium (2008)
  • Author(s): Masashi Tanaka, et. al.
  • Journal Title: Modern Rheumatology 18 Pages: 125-125
• [Presentation] Distribution of Z39Ig-expressing macrophages in murine normal tissues and diseased tissues (2008)
  • Author(s): Masashi Tanaka et al
  • Organizer: 日本免疫学会
  • Place of Presentation: 国立京都国際会館(京都市)
• [Presentation] 関節リウマチ滑膜に出現するZ39Ig+CD11c+マクロファージサブセットの解析 (2008)
  • Author(s): 田中将志 他
  • Organizer: 第52回日本リウマチ学会
  • Place of Presentation: ロイトン札幌他(札幌市)
• [Presentation] 関節リウマチ滑膜に出現するZ391g+CDllc+マクロファージサブセットの解析 (2008)
  • Author(s): 田中将志, 他
  • Organizer: 第52回日本リウマチ学会
  • Place of Presentation: ロイトン札幌他(札幌市)
• [Presentation] Expansion of Z39Ig+CD11c+ macrophages in rheumatoid arthritis synovium (2007)
  • Author(s): Masashi Tanaka et al
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Expansion of Z38Ig+CD11c+macrophages in rheumatoid arthritis synovium (2007)
  • Author(s): Masashi Tanaka, et. al.
  • Organizer: 日本免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] The Z39Ig : a specific marker of synovial A cells in RA synovium (2007)
  • Author(s): Masashi Tanaka et al
  • Organizer: The 5th International Symposium of Molecular Pathology
  • Place of Presentation: 鹿児島
  • Year and Date: 2007-07-31
• [Presentation] The Z39Ig:a specific marker of synovial A cells in RA synovium (2007)
  • Author(s): Masashi Tanaka, et. al.
  • Organizer: The 5th International Symposium of Molecular Pathology
  • Place of Presentation: 鹿児島
  • Year and Date: 2007-07-31
• [Patent(Industrial Property Rights)] がん関連マクロファージを標的とした固形がん治療剤 (2008)
  • Inventor(s): 松山隆美、永井拓、田中将志
  • Industrial Property Number: 2008-130882
  • Filing Date: 2008-05-19