Investigation of the mechanism of food allergy development on germ free mice and the approach to therapy
Project/Area Number |
19790694
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Tokyo Medical University |
Principal Investigator |
ISHIKAWA Hiroki Tokyo Medical University, 医学部, 助教 (60433918)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
|
Keywords | 経口トレランス / 消化管細菌叢 / 消化管粘膜免疫誘導組織 / 食物アレルギー / Germ freeマウス / 制御性T細胞 / 消化管粘膜免疫組織 / 制御性細胞 / Germ free マウス |
Research Abstract |
A failure of oral tolerance induction leads to susceptibility to food antigens. When oral tolerance was induced in either SPF or GF mice, oral tolerance was successfully induced in SPF mice, but not in GF mice. One of mechanisms by which oral tolerance could not be induced in GF mice was attributed to impaired number and function of CD25+CD4+ regulatory T cell in GALT of GF mice. Indigenous microbiota were thus considered to contribute to the induction and maintenance of CD25+CD4+ regulatory T cell in GALT.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Protective potential of Bacillus coagulans, a spore-forming lactic acid bacterium, against cytomegalovirus infection.2009
Author(s)
Shimizu K., Koga Y., Aiba Y., Kobayashi K., Hata A., Ishikawa H., Kametani Y., Tanaka K., Noda S
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Journal Title
Report Jpn. Assoc. Biol. Func. Res. 13
Pages: 34-46
Related Report
Peer Reviewed
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[Journal Article] Interleukin-1 deficiency in combination with macrophage depletion increases susceptibility to Psedomonas aeruginosa bacteremia.2009
Author(s)
Horino T., Matsumoto T., Ishikawa H., Kimura S., Uramatsu M., Tanabe M., Tateda K., Miyazaki S., Aramaki Y., Iwakura Y., Yoshida M., Onodera S., Yamaguchi K.
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Journal Title
Microbiol. Immunol. 53(9)
Pages: 502-511
Related Report
Peer Reviewed
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