Association of the PD1/PD-L co-stimulatory pathway in lupus nephritis.

• Project/Area Number: 19790701
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: 財団法人田附興風会 (2009); Tazuke Kofukai Medical Research Institute (2007-2008)
• Principal Investigator: HATACHI Saori 財団法人田附興風会, 医学研究所第4研究部, 研究員 (70414117)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,340,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 膠原病学 / ループス腎炎 / PD-1 / PD-L1

Research Abstract

To investigate the role of the PD-1/PD-L system in the pathology of renal involvement of systemic antoimmune diseases (SAD), we examined the expression of PD-1 and its ligand PD-L1 in renal biopsy specimens from patients with SAD. Immunohistochemical analysis showed that PD-1/PD-L1 was expressed on inflammatory cells infiltrated in the periglomerular regions and on urinary tube epithelial cells. These findings were no relation to the type of SAD and the subclasses of lupus nephritis. Unlikely on our previous report about NZB/W F1 mice, a model of lupus-like nephritis, PD-L1 was not expressed in the glomeruli. These results suggested that the PD-1/PD-L1 pathway may be related to the immunological reaction in the progression to nephritis.

Research Products

• [Journal Article] Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice (2010)
  • Author(s): Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S
  • Journal Title: J Immunol 184(5) Pages: 2337-47
  • Peer Reviewed
• [Journal Article] Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice (2010)
  • Author(s): Kasagi S, Kawano S, Okazaki T, Honjo T, Morinobu A, Hatachi S, Shimatani K, Tanaka Y, Minato N, Kumagai S.
  • Journal Title: J Immunol. 184 Pages: 2337-47
  • Peer Reviewed
• [Journal Article] Dermatomyositis associated with thyroid cancer (2008)
  • Author(s): Fujita M, Hatachi S, Yagita M.
  • Journal Title: Rheumatol Int. 29(2) Pages: 203-5
  • Peer Reviewed
• [Journal Article] Reversible posterior leukoencephalopathy syndrome in a patient with Takayasu arteritis (2008)
  • Author(s): Fujita M, Komatsu K, Hatachi S, Yagita M.
  • Journal Title: Mod Rheumatol. 18(6) Pages: 623-9
  • NAID: 10025111722
  • Peer Reviewed
• [Journal Article] Immunohistochemically proven cytomegalovirus gastrointestinal diseases in three patients with autoimmune diseases (2008)
  • Author(s): Fujita M, Hatachi S, Yagita M.
  • Journal Title: Clin Rheumatol 27(8) Pages: 1057-9
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of serum procalcitonin concentrations for detecting systemic bacterial infection in patients with systemic autoimmune diseases (2008)
  • Author(s): Tamaki K, Kogata Y, Sugiyama D, Nakazawa T, Hatachi S
  • Journal Title: J Rheumatol. 35(1) Pages: 114-9
  • Peer Reviewed
• [Journal Article] Diagnostic accuracy of serum procalcitonin concentrations for detecting systemic bacterial infection in patients with systemic autoimmune diseases. (2008)
  • Author(s): Tamaki K, Kogata Y, Sugiyama D, Nakazawa T, Hatachi S, Kageyama G, Nishimura K, Morinobu A, Kumagai S.
  • Journal Title: J Rheumatol. 35 Pages: 114-119
  • Peer Reviewed
• [Journal Article] Immunohistochemically proven cytomegalovirus gastrointestinal diseases in three patients with autoimmune diseases. (2008)
  • Author(s): Fujita M, Hatachi S, Yagita M.
  • Journal Title: Clin Rheumatol. Feb 12 Epub a head of print
  • Peer Reviewed
• [Journal Article] Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of patients with Sjogren's syndrome (2007)
  • Author(s): Kurimoto C, Kawano S, Tsuji G, Hatachi S
  • Journal Title: J Rheumatol. 34(10) Pages: 2035-43
  • Peer Reviewed
• [Journal Article] Thioredoxin may exert a protective effect against tissue damage caused by oxidative stress in salivary glands of Patients with Sjogren's syndrome. (2007)
  • Author(s): Kurimoto C, Kawano S, Tsuji G, Hatachi S, Jikimoto T, Sugiyama D, Kasagi S, Komori T, Nakamura H, Yodoi J, Kumagai S.
  • Journal Title: J Rheumatol. 34 Pages: 2035-2043
  • Peer Reviewed
• [Presentation] 全身性エリテマトーデスに伴う間質性腎炎を発症した1例 (2010)
  • Author(s): 西田美和、大西輝、籏智さおり、古宮俊幸、八木田正人
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] 全身性自己免疫疾患の腎組織におけるPD-1/PD-L分子の発現 (2009)
  • Author(s): 籏智さおり、笠木伸平、河野誠司、熊谷俊一
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京都 東京ステーションコンファレンス
  • Year and Date: 2009-11-13
• [Presentation] 全身性自己免疫疾患の腎組織におけるPD-1/PD-L分子の発現 (2009)
  • Author(s): 籏智さおり、笠木伸平、河野誠司、熊谷俊一
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーションコンファレンス
• [Presentation] Involvement of IFN-γproducing CD4+ PD-1+ T cells in lupus-prone NZB/W F1 mice (2008)
  • Author(s): Shimpei Kasagi, Kawano Seiji, Akio Morinobu, Saori Hatachi
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] ループス腎炎モデルマウスにおけるPD-1およびPD-L1の機能解析 (2008)
  • Author(s): 笠木伸平、河野誠司、森信暁雄、籏智さおり、熊谷俊一
  • Organizer: 第52回日本リウマチ学会総会・学術集会
  • Place of Presentation: ロイトン札幌
• [Presentation] Expression of PD-1/PD-L1 in the development of lupus-like nephritis in NZB/W mice (2007)
  • Author(s): Kasagi S, Kawano S, Hatachi S, Mrinobu A, Tanaka Y, Okazaki T, Minato N, Honjo T, Kumagai S.
  • Organizer: The 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2007-11-20