Contribution of neural crest-derived and bone marrow-derived cells to the development of pulmonary hypertension : Study using mutant mouse models

• Project/Area Number: 19790715
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Mie University
• Principal Investigator: OHASHI Hiroyuki Mie University, 医学部・附属病院, 助教 (70397511)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 肺高血圧 / 先天性心疾患 / 幹細胞 / 神経堤細胞 / マウスモデル / 低酸素 / 再生医学 / 神経堤 / 骨髄

Research Abstract

肺高血圧の病変形成に関与しうる幹細胞の動態を知る事は本症の病態理解に重要である。生体内の幹細胞の由来として、胎児期の神経堤細胞と骨髄細胞が注目される。そこで神経堤細胞を追跡できる遺伝子改変マウス及び骨髄細胞を追跡できる蛍光色素発現マウス骨髄の移植モデルを用いて、肺高血圧性肺血管病変へのそれらの細胞の存在分布を検討した。各細胞が肺高血圧に病変に認められ、病変を促進的、抑制的に働く可能性が示唆された。

Research Products

• [Journal Article] In Vivo Plaque Composition and Morphology in Coronary Artery Lesions in The Adolescents and Young Adults Long After Kawasaki Disease : A Virtual Histology-Intravascular Ultrasound Study (2009)
  • Author(s): Mitani Y, Ohashi H, Maruyama K, Shimpo H, 計9名
  • Journal Title: Circulation (in press)
  • Peer Reviewed
• [Journal Article] Suture repair of pectus excavatum at the time of cardiac surgery on an infant (2008)
  • Author(s): Takabayashi S, Ohashi H, Mitani Y, Shimpo H. 計5名
  • Journal Title: Ann Thorac Surg. 85(2) Pages: 651-3
  • Peer Reviewed
• [Journal Article] Suture repair of pectus excavatum at the time of cardiac surgery on an infant (2008)
  • Author(s): Takabayashi S, Ohashi H, et. al.
  • Journal Title: Ann Thorac Surg 85 Pages: 651-653
  • Peer Reviewed
• [Journal Article] Fate of the 'opened' arterial duct : Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandin E1. (2007)
  • Author(s): Mitani Y, Ohashi H, Maruyama K, Shimpo H, 計10名
  • Journal Title: J Thorac Cardiovasc Surg. 133(6) Pages: 1653-4
  • Peer Reviewed
• [Journal Article] Reversal of increased pulmonary arterial pressure associated with systemic venous collaterals after tonsillectomy in a Fontan candidate after Glenn procedure : Impact of obstructive sleep apnea on Fontan circulation. (2007)
  • Author(s): awada H, Mitani Y, Ohashi H, Maruyama K. 計9名
  • Journal Title: J Thorac Cardiovasc Surg. 133(5) Pages: 1371-3
  • Peer Reviewed
• [Journal Article] Fate of the 'opened' arterial duct: Lessons learned from bilateral pulmonary artery banding for hypoplastic left heart syndrome under the continuous infusion of prostaglandia E1 (2007)
  • Author(s): Mitani Y、Ohashi H, et. al.
  • Journal Title: J Thorac Cardiovasc Surg 133 Pages: 1653-1654
  • Peer Reviewed
• [Journal Article] Reversal of increased pulmonary arterial pressure associated with systemic venous collaterals after tonsillectomy in a Fontan candidate after Glenn procedure: Impact of obstructive sleep apnea on Fontan circulation. (2007)
  • Author(s): Sawada H, Ohashi H, et. al.
  • Journal Title: J Thorac Cardiovasc Surg 133 Pages: 1371-1373
  • Peer Reviewed
• [Presentation] Necrotic Core and Dense Calcium, not Fibrous, Components contribute to an Increased Plaque Burden Associated with Localized Stenosis in Patients Long after Kawasaki Disease : Quantitative Gray Scale- and Virtual Histology- Intravascular Ultrasound Study (2008)
  • Author(s): Mitani Y, Ohashi H, 計5名
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans, US
  • Year and Date: 2008-11-10
• [Presentation] Necrotic Core and. Dense Calcium, not Fibrous, Components contribute toan Increased Plaque Burden Associated with Localized Stenosis in Patients Long after Kawasaki Disease : Quantitative Gray Scale- and Virtual Histology-Intravascular Ultrasound Study (2008)
  • Author(s): Mitani Y, Ohashi H, Sawada H, Hayakawa H, Komada Y
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2008-11-10
• [Presentation] In Vivo Plaque Composition and Morphology in Coronary Artery Lesions in the Adolescents and Young Adults Long after Kawasaki Disease : Lessons Learned from Virtual Histology- Intravascular Ultrasound Study (2007)
  • Author(s): Mitani Y, Ohashi H, 計5名
  • Organizer: American Heart Association
  • Place of Presentation: Orland, US,
  • Year and Date: 2007-11-07
• [Presentation] In Vivo Plaque Composition and Morphology in Coronary Artery Lesions in the Adolescents and Young Adults Long after Kawasaki Disease: Lessons Learned from Virtual Histology-Intravascular Ultrasound Study (2007)
  • Author(s): Mitani Y, Ohashi H, et. al.
  • Organizer: American Heart Association
  • Place of Presentation: Orland, US
  • Year and Date: 2007-11-05
• [Presentation] 先天性心疾患の治療計画におけるSildenafilの有用性(第1報):non-PH群への応用 (2007)
  • Author(s): 三谷義英、大橋啓之, 他
  • Organizer: 日本小児循環器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-05
• [Presentation] Glenn術後のFontan candidateに合併した肺静脈閉塞の原因と予後 (2007)
  • Author(s): 大橋啓之、三谷義英, 他
  • Organizer: 日本小児循環器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-04