Identification and characterization of a novel FGF-binding protein and its possibilities for clinical application.

• Project/Area Number: 19790717
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Kyoto University
• Principal Investigator: YAMANAKA Yasunari Kyoto University, 大学院医学研究科, 助教 (90402859)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,550,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 小児神経学 / 遺伝子 / 再生医学 / 神経科学 / 脳・神経 / 発生・分化

Research Abstract

研究成果の概要: 新規FGF-2結合蛋白質(FGF-BP3)は成体の前頭葉眼窩野に特異的に発現し、その遺伝子改変マウスは新奇環境下で不安様行動を示した。このとき前頭葉眼窩野においてERKのリン酸化と初期誘導遺伝子c-fosの発現が減弱していた。つまりFGF-BP3はFGF-ERKシグナルに関与し、不安を司る前頭葉の高次機能を制御していた。本研究の結果から、遺伝子とこころを繋ぐ成果が得られたとともに、FGF-BP3が不安障害に対する薬剤開発の対象分子になりうる可能性を示した。

Research Products

• [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. (2008)
  • Author(s): Yamanaka Y, Heike T, Kumada T, Shibata T, Takaoka Y, Kitano A, Shiraishi K, Kato T, Nagato M, Okawa K, Furushima K, Nakao K, Nakamura Y, Taketo MM, Aizawa S, Nakahata T
  • Journal Title: Mech. Dev. 125 Pages: 441-450
• [Journal Article] Deterioration on magnetic resonance imaging despite good clinical recovery after viral encephalitis. (2008)
  • Author(s): Awaya T, Kato T, Shibata T, Yamanaka Y, Nakahata T
  • Journal Title: Pediatr. Neurol. 38 Pages: 218-220
• [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality (2008)
  • Author(s): Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, at.al.
  • Journal Title: Mechanisms of Development 125 Pages: 441-450
  • Peer Reviewed
• [Journal Article] Deterioration on magnetic resonance imaging despite good clinical recovery after viral encephalitis (2008)
  • Author(s): Awaya T, Kato T, Shibata M, Yamanaka Y, Nakahata T
  • Journal Title: Pediatric Neurology 38 Pages: 218-220
  • Peer Reviewed
• [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic (2008)
  • Author(s): Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, et. al.
  • Journal Title: Mechanisms of Development Online
  • Peer Reviewed
• [Journal Article] Deterioration on magnetic resonance imaging despite good clinical recovery after viral encephalitis. (2008)
  • Author(s): Awaya T, Kato T, Shibata M, Yamanaka Y, Nakahata T.
  • Journal Title: Pediatric Neurology 38 Pages: 218-220
  • Peer Reviewed