An artificial placenta using a sheep model

Research Project

Project/Area Number	19790755
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Embryonic/Neonatal medicine
Research Institution	Tohoku University
Principal Investigator	MIURA Yuichiro Tohoku University, 病院, 特任助手 (20419229)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords	人工胎盤 / 人工羊水 / 人工子宮 / 胎児循環 / 膜型人工肺 / 動脈管 / マイクロスフェア法
Research Abstract	Our purpose was to develop an artificial placenta in a form of a pumpless arteriovenous extracorporeal life support circuit, in which infant's own blood pressure droved the system. In an animal experiment using the chronically instrumented fetal sheep, we could demonstrate that this system could support gas exchange and maintain fetal circulation for 15~30 hours. Prolonged support assured cerebral oxygen delivery would require a parallel circuit based on a low resistance oxygenator.