Inhibition of prostanoid productions as prophylaxis and therapeutic strategy for treatment of long lasting neuronal death in excitotoxicity
| Project/Area Number |
19790766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
YOSHIKAWA Keisuke Institute for Developmental Research, Aichi Human Service Center, 病理学部, 研究員 (10435860)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,350,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 神経変性 / プロスタノイド / 脂質メディエーター / カイニン酸 / LC-MS / MS / 低酸素性虚血性脳症 / 神経細胞死 / プロスタグランジン / LC-ESI-MS / シクロオシキゲナーゼ / ラット |
|---|
| Research Abstract |
低酸素性虚血性脳症モデルラットの脳内にて産生されるプロスタノイドをNSAID投薬によって抑制することにより、ミクログリア活性化を抑制し、その後の神経細胞死を予防・治療できる可能性が示された。
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] The Senescence-accelerated Mouse (SAM) : a higher oxidative stress and agedependent degenerative diseases model.2009
Author(s)
Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura M., Kawamura, N., and Hosokawa, M.
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Journal Title
Neurochem. Res. 34
Pages: 679-87
Related Report
Peer Reviewed
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[Journal Article] Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level.2008
Author(s)
Satoh, M., Shimada, A., Kawamura, N., Chiba, Y., Yoshikawa, K., Ishii, S., Furukawa, A., Kumagai, N., and Hosokawa, M.
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Journal Title
Neuropathology. 28
Pages: 485-496
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of MAb6B4 epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from the cerebral cortices of SAMP10 mice : A model for age-dependent neurodegeneration.2008
Author(s)
Saitoh, Y., Matsui, F., Chiba, Y., Kawamura, N., Keino, H., Satoh, M., Kumagai, N., Ishii, S., Yoshikawa, K., Shimada, A., Maeda, N., Oohira, A., and Hosokawa, M.
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Journal Title
J. Neurosci. Res. 86
Pages: 1316-1323
Related Report
Peer Reviewed
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[Journal Article] The Senescence-accelerated Mouse(SAM): a higher oxidative stress and age-dependent degenerative diseases model.2008
Author(s)
Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura M., Kawamura, N., Hosokawa, M.
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Journal Title
Neurochem. Res. (印刷中 Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Neuronal toxicity of expanded polyglutamine depends on intracellular distribution in addition to the expression level2008
Author(s)
Satoh, M., Shimada, A., Kawa-mura, N., Chiba, Y., Yoshikawa, K., Ishii, S., Furukawa, A., Kumagai, N., and Hosokawa, M.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Reduced expression of MAb6B4-epitopes on chondroitin sulfate proteoglycan aggrecan in perineuronal nets from the cerebral cortices of SAMP10 mice, a model for age-dependent neurodegeneration2008
Author(s)
Saitoh, Y., Matsui, F., Chiba, Y., Kawamura, N., Keino, H., Satoh, M., Kumagai, N., Ishii, S., Yoshikawa, K., Shimada, A., Maeda, N., Oohira, A., and Hosokawa, M.
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Journal Title
Journal of Neuroscience Research in press
Related Report
Peer Reviewed
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[Journal Article] Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse.2007
Author(s)
Kumagai, N., Chiba, Y., Hosono, M., Fujii, M., Kawamura, N., Keino, H., Yoshikawa, K., Ishii, S., Saitoh, Y., Satoh, M., Shimada, A., and Hosokawa, M.
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Journal Title
Brain Res. 1185
Pages: 75-85
Related Report
Peer Reviewed
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[Journal Article] Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse2007
Author(s)
Kumagai, N., Chiba, Y., Hosono, M., Fujii, M., Kawamura, N., Keino, H., Yoshikawa. K., Ishii, S., Saitoh, Y., Satoh, M., Shimada, A., and Hosokawa, M.
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Journal Title
Brain Research 1185
Pages: 75-85
Related Report
Peer Reviewed
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[Presentation] SAMP10マウス大脳皮質におけるプロテオグリカン関連エピトープ6B4の発現低下2007
Author(s)
松井ふみ子, 齊藤優子, 河村則子, 慶野裕美, 千葉陽一, 熊谷直子, 石井さなえ, 吉川圭介, 島田厚良, 前田信明, 大平敦彦, 細川昌則
Organizer
第30回日本神経科学大会
Place of Presentation
横浜市
Year and Date
2007-09-10
Related Report
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[Presentation] 加齢に伴うミクログリアの退行性変化2007
Author(s)
石井さなえ, 島田厚良, 千葉陽一, 吉川圭介, 古川絢子, 河村則子, 熊谷直子, 細川昌則
Organizer
第22回老化促進モデルマウス(SAM)研究協議会
Place of Presentation
酒田市
Year and Date
2007-07-27
Related Report
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