Development of a novel sonodynamic therapy for skin cancers

• Project/Area Number: 19790769
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Hirosaki University
• Principal Investigator: MATSUZAKI Yasushi Hirosaki University, 医学部・附属病院, 講師 (50322946)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,170,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 皮膚腫瘍学 / 音響力学 / 増感剤 / ATX-70 / 悪性黒色腫 / 細胞死

Research Abstract

新規光増感剤ATX-70は、培養ヒト有棘細胞癌細胞に対し光力学ならびに音響力学効果を示し、培養マウスメラノーマ細胞に対しても70%以上の細胞死を生じる音響力学効果がみられた。メラノーマモデルマウスに対して、ATX-70の濃度、超音波照射時間の延長など様々な条件で施行したが、臨床的および組織学的に有意な音響力学作用は認められず、さらなる研究が必要である。

Research Products

• [Journal Article] CD20+ primary cutaneous T-cell lymphoma presenting as a solitary extensive plaque. (2009)
  • Author(s): Oshima H, Matsuzaki Y, et al. (2/5)
  • Journal Title: Br J Dermatol 160 Pages: 894-6
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa. (2008)
  • Author(s): Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, et al. (7/10)
  • Journal Title: J Dermatol 35 Pages: 336-40
  • NAID: 10024297026
  • Peer Reviewed
• [Journal Article] Vitamin D3 inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis. (2008)
  • Author(s): Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, et al. (4/6)
  • Journal Title: J Dermatol Sci 50 Pages: 155-8
  • Peer Reviewed
• [Journal Article] Vitamin D 3 inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis (2008)
  • Author(s): Chiaki Yamamoto
  • Journal Title: J Dermatol Sci 2 Pages: 155-158
  • Peer Reviewed
• [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa (2008)
  • Author(s): Akiko Rokunohe
  • Journal Title: J Dermatol 6 Pages: 336-340
  • Peer Reviewed
• [Journal Article] A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens. (2007)
  • Author(s): Nishizawa A, Toyomaki Y, Nakano A, Takeuchi S, Matsuzaki Y, et al. (5/9)
  • Journal Title: Br J Dermatol 156 Pages: 1042-4
  • Peer Reviewed
• [Journal Article] Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes. (2007)
  • Author(s): Kitamura H, Matsuzaki Y, et al. (2/7)
  • Journal Title: J Dermatol Sci 45 Pages: 127-34
  • NAID: 10024115326
  • Peer Reviewed
• [Journal Article] A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens (2007)
  • Author(s): Aya Nishizawa, et. al.
  • Journal Title: British Journal of Dermatology 156 Pages: 1042-1044
  • Peer Reviewed
• [Journal Article] Interferon-γ down-regulates expression of the 230-kDa bullous pemphigoid antigen gene (BPAG1) in epidermal keratinocytes via novel chimeric sequences of ISRE and GAS. (2006)
  • Author(s): Kaneko T, Tamai K, Matsuzaki Y, et al. (3/10)
  • Journal Title: Exp Dermatol 15 Pages: 308-14
  • Peer Reviewed
• [Journal Article] Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species. (2006)
  • Author(s): Nakano H, Ikenaga S, Aizu T, Kaneko T, Matsuzaki Y, et al. (5/8)
  • Journal Title: Biol Pharm Bull 29 Pages: 55-9
  • Peer Reviewed
• [Journal Article] Transcriptional regulation and characterization of the promoter region of the human ABCC6 gene (2006)
  • Author(s): Jiang Q, Matsuzaki Y, co-first, et al. (1/4)
  • Journal Title: J Invest Dermatol 126 Pages: 325-35
  • Peer Reviewed
• [Journal Article] Tissue-specific expression of the ABCC6 gene. (2005)
  • Author(s): Matsuzaki Y, et al. (1/5)
  • Journal Title: J Invest Dermatol 125 Pages: 900-9
  • Peer Reviewed
• [Journal Article] Sugar micro needles as transdermic drug delivery system. (2005)
  • Author(s): Miyano T, Tobinaga Y, Kanno T, Matsuzaki Y, et al. (4/7)
  • Journal Title: Biomed Microdevices 7 Pages: 185-8
  • Peer Reviewed
• [Journal Article] Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid. (2005)
  • Author(s): Takeda H, Kaneko T, Harada K, Matsuzaki Y, et al. (4/6)
  • Journal Title: Dermatology 211 Pages: 264-6
  • Peer Reviewed
• [Journal Article] Targeted ablation of the Abcc6 gene results in ectopic mineralization of connective tissues. (2005)
  • Author(s): Klement JF, Matsuzaki Y, co-first, et al. (1/11)
  • Journal Title: Mol Cell Biol 25 Pages: 8299-310
  • Peer Reviewed
• [Journal Article] Keratinocyte responsive element 3: Analysis of a keratinocyte-specific regulatory sequence in the 230-kDa bullous pemphigoid antigen gene promoter (2003)
  • Author(s): Matsuzaki Y, et al. (1/6)
  • Journal Title: J Invest Dermatol 120 Pages: 308-12
  • Peer Reviewed
• [Journal Article] Localized pagetoid reticulosis (Woringer-Kolopp disease) in early childhood.
  • Author(s): Matsuzaki Y, et al.(1番目/5名)
  • Journal Title: J Am Acad Dermatol in press
  • Peer Reviewed
• [Presentation] UVBとウイルス感染がretinoic acid-inducible gene-I (RIG-I)発現に与える影響について (2008)
  • Author(s): 木村一之
  • Organizer: 日本皮膚科学会青森地方会第344回例会
  • Place of Presentation: 弘前
  • Year and Date: 2008-12-07
• [Presentation] 新しい皮膚癌治療法の開発-超音波を用いた音響力学療法- (2007)
  • Author(s): 松崎 康司
  • Organizer: 第106回 日本皮膚科学会総会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Year and Date: 2007-04-21
• [Presentation] Effect of ultraviolet B irradiation and viral infection on retinoic acid-inducible genge-I expression (2007)
  • Author(s): Kimura K
  • Organizer: 37th Annual Meeting of the ESDR
  • Place of Presentation: Switzerland
• [Presentation] Tumor necrosis factor-α and Interferon-γ synergistically induce retinoic acid-inducible gene-I in cultured human keratinocytes (2006)
  • Author(s): Minakawa S
  • Organizer: 36th Annual Meeting of the ESDR
  • Place of Presentation: France
• [Presentation] Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes in vivo and in vitro (2006)
  • Author(s): Kitamura H
  • Organizer: 67th Annual Meeting of the SID
  • Place of Presentation: USA
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~derma/index.html
• [Remarks]
  • URL: http://www.med.hirosaki-u.ac.jp/~derma/index.html