Mechanisms of progression in skin cancers

• Project/Area Number: 19790774
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: KAKINUMA Takashi The University of Tokyo, 医学部附属病院, 講師 (30332604)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 皮膚悪性腫瘍 / CXCR4 / CCR10 / CCL27 / 悪性黒色腫 / ケモカイン / beta-7インテグリン / 有棘細胞癌

Research Abstract

平成19年度から20年度の研究により、悪性黒色腫ではケモカイン受容体CXCR4,CCR10は原発巣、転移巣ともに発現は軽度であり進展には関与していないことが分かった。一方、皮膚有棘細胞癌(SCC)ではCCR10-CCL27が腫瘍細胞で共発現しており、他の皮膚悪性腫瘍ではみられない興味深い結果を得た。SCC細胞株を用いても同様の結果であり、SCCではCCR10-CCL27が腫瘍の成長に関与している可能性が示唆された。悪性黒色腫の進展についてはマウスを用いて更に検討を行い、細胞接着因子beta7-integrinノックアウトマウス皮膚にB16メラノーマを接種するとコントロール群と比べ成長が促進し、接着因子beta7が皮膚でのメラノーマの成長に関与している可能性が示唆された。

Research Products

• [Journal Article] Interferon-18 gene polymorphism -137 G/C is associated with susceptibility to psoriasis vulgaris but not with atopic dermatitis in Japanese patients. (2009)
  • Author(s): Kato T, Tsunemi Y, Saeki H, Shibata S, Sekiya T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K.
  • Journal Title: J Dermatol Sci. 53 Pages: 162-3
  • NAID: 10025332553
• [Journal Article] IL-17F single nucleotide polymorphism is not associated with psoriasis vulgaris or atopic dermatitis in the Japanese population. (2009)
  • Author(s): Shibata S, Saeki H, Tsunemi Y, Kato T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K.
  • Journal Title: J Dermatol Sci. 53 Pages: 163-5
  • NAID: 10025332564
• [Journal Article] Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid. (2008)
  • Author(s): Saeki H, Watanabe A, Tada Y, Kakinuma T, Komine M, Ihn H, Asahina A, Etoh T, Kitanaka S, Sato U, Kano H, Igarashi T, Tamaki K.
  • Journal Title: J Dermatol 35 Pages: 601-3
  • NAID: 10024298051
• [Journal Article] Rapid accumulation of epidermal CCL27 in skin-draining lymphnodes following topical application of a contact sensitizer recruits (2008)
  • Author(s): Kakinuma T, et.al
  • Journal Title: Journal of Immunology 180(10) Pages: 6462-6468
  • Peer Reviewed
• [Journal Article] Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location. (2007)
  • Author(s): Kakinuma T, et. al.
  • Journal Title: Cancer Immunol Immunother 56 Pages: 1119-1131
  • Peer Reviewed
• [Presentation] A case of myopericytoma (2008)
  • Author(s): Kakinuma T and Tamaki K
  • Organizer: 8th Asian Dermatological Congress
  • Place of Presentation: Souel, Korea
  • Year and Date: 2008-09-30
• [Book] 高齢者と皮膚悪性腫瘍 (2008)
  • Author(s): 柿沼誉
  • Publisher: 協和企画