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Analyses of systemic and topical cutaneous symptoms caused by Epstein-Barr virus related disorders

Research Project

Project/Area Number 19790787
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionOkayama University

Principal Investigator

YAMAMOTO Takenobu  Okayama University, 医学部・歯学部附属病院, 医員 (50379799)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords皮膚感染症 / EBウイルス / 細胞傷害性T細胞 / 潜伏感染 / 溶解感染 / 再活性化 / BZLF 1 / LMP 1 / 細胞障害性T細胞 / 種痘様水庖症 / 慢性活動性EBウイルス感染症 / LMP / 種痘様水疱症 / 慢性活動性EBウィルス感染症
Research Abstract

EBウイルス関連疾患が皮膚症状、発熱などの全身症状をきたすメカニズムとして、宿主側の反応であるEBウイルス感染細胞に対する細胞傷害性T細胞の役割が大きい。細胞傷害性T細胞の皮膚病変部への浸潤が強い例は、重篤な症状を引き起こしやすい。一方、EBウイルス側にとって、細胞傷害性T細胞の反応は不利になるため、発現する抗原を必要最低限にし、さらに抗原の発現・消失を状況に応じて調節することにより宿主に認識されにくいようにしている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (2 results)

  • [Journal Article] EBV関連皮膚疾患の診断と治療2008

    • Author(s)
      山本剛伸、岩月啓氏
    • Journal Title

      Monthly Book Derma 147

    • Related Report
      2008 Final Research Report
  • [Journal Article] EBウイルスとリンパ増殖症2008

    • Author(s)
      山本剛伸、山田晶子、岩月啓氏、
    • Journal Title

      日本皮膚科学会雑誌 118

      Pages: 3059-3068

    • NAID

      10025379239

    • Related Report
      2008 Final Research Report
  • [Journal Article] Tracing of the molecular remnants of herpes virus infections in necrotic skin tissue2008

    • Author(s)
      Takenobu Yamamoto, Akiko Yamada, Kazuhide Tsuji, Keiji Iwatsuki
    • Journal Title

      Eur J Dermatol. 18

      Pages: 499-503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 黒幕EBウイルスによる皮膚疾患2007

    • Author(s)
      山本 剛伸
    • Journal Title

      診断と治療 95

      Pages: 16321639-16321639

    • Related Report
      2007 Annual Research Report
  • [Journal Article] EBウイルスと皮膚疾患2007

    • Author(s)
      山本 剛伸
    • Journal Title

      小児科臨床 60増

      Pages: 14271432-14271432

    • Related Report
      2007 Annual Research Report
  • [Presentation] Reactivation of Epstein-Barr virus is associated with severe cutaneous and systemic symptoms2008

    • Author(s)
      Takenobu Yamamoto
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Reactivation of Epstein-Barr virus is associated with severe cutaneous and systemic symptoms2008

    • Author(s)
      山本剛伸
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] EBV gene expression and Host immune system2008

    • Author(s)
      Takenobu Yamamoto
    • Organizer
      Satellite Workshop of IID 2008 in Kyoto
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-05-13
    • Related Report
      2008 Final Research Report
  • [Presentation] EBV関連疾患の悪性化を評価するバイオマーカー2008

    • Author(s)
      山本剛伸
    • Organizer
      第18回岡山研究皮膚科フォーラム
    • Place of Presentation
      岡山市
    • Year and Date
      2008-01-19
    • Related Report
      2008 Final Research Report
  • [Presentation] ヘルペスウイルス感染とアポトーシス2008

    • Author(s)
      山本剛伸
    • Organizer
      日本皮膚科学会岡山地方会
    • Place of Presentation
      岡山市
    • Year and Date
      2008-01-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Detection .9f pathogen-derived transcripts in crusts2007

    • Author(s)
      Takenobu Yamamoto
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Los Angeles
    • Year and Date
      2007-05-11
    • Related Report
      2007 Annual Research Report
  • [Book] 皮膚感染症のすべて2009

    • Author(s)
      山本剛伸、山田晶子、岩月啓氏、南江堂
    • Related Report
      2008 Final Research Report
  • [Book] EBウイルスと皮膚疾患2007

    • Author(s)
      山本 剛伸
    • Publisher
      メディカル レビュー社
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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