Suppression of tumorigenesis by epidermal remodeling

• Project/Area Number: 19790790
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kurume University
• Principal Investigator: DAINICHI Teruki Kurume University, 医学部, 講師 (20423543)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,290,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: ケミカルピーリング / 紫外線 / 角化細胞 / 皮膚腫瘍学

Research Abstract

紫外線発癌モデルマウスにおけるサリチル酸マクロゴールピーリングによる発癌抑制が、シクロオキシゲナーゼ阻害による直接作用であることを否定した。機械的ストレスシグナル伝達物質のひとつである活性化ERKの発現が施術により変化することを示した。

Research Products

• [Journal Article] Lesional Th17 cells in pemphigus vulgaris and pemphigus foliaceus. (2009)
  • Author(s): Arakawa M, Dainichi T, Yasumoto S, Hashimoto T.
  • Journal Title: J Dermatol Sci 53 Pages: 228-31
  • NAID: 10025332904
  • Peer Reviewed
• [Journal Article] Anti-laminin gamma-1 pemphigoid. (2009)
  • Author(s): Dainichi T, Kurono S, Ohyama B, Ishii N, Sanzen N, Hayashi M, Shimono C, Taniguchi Y, Koga H, Karashima T, Yasumoto S, Zillikens D, Sekiguchi K, Hashimoto T.
  • Journal Title: Proc Natl Acad Sci U S A 106 Pages: 2800-5
  • Peer Reviewed
• [Journal Article] Bullous pemphigoid followed by pustular psoriasis showing immunological dynamics among Th1, Th2, Treg and Th17. (2009)
  • Author(s): Yasukawa S, Dainichi T, Kokuba H, Moroi Y, Urabe K, Hashimoto T, Furue M.
  • Journal Title: Eur J Dermatol 19 Pages: 69-71
  • Peer Reviewed
• [Journal Article] Anti-laminin gamma-1 pemphigoid (2009)
  • Author(s): Dainichi T, et.al.
  • Journal Title: Proc Natl Acad Sci USA 1062 Pages: 2800-2805
  • Peer Reviewed
• [Journal Article] Bullous pemphigoid followed by pustular psoriasis showing Thl, Th2, Trea and Th17 immunological changes (2009)
  • Author(s): Yasukawa S, Dainichi T, et.al.
  • Journal Title: Eur J Dermatol 19 Pages: 69-71
  • Peer Reviewed
• [Journal Article] Lesinnal Th17 cells in nemnhigus vulgaris and nemnhigus foliaceus (2009)
  • Author(s): Arakawa M, Dainichi T, et.al.
  • Journal Title: J Dermatol Sci 53 Pages: 228-231
  • Peer Reviewed
• [Journal Article] Paraneoplastic acanthosis nigricans accompanied by silent meningioma producing transforming growth factor-alpha. (2008)
  • Author(s): Dainichi T, Moroi Y, Duan H, Urabe K, Koga T, Miyazono M, Sasaki T, Hashimoto T, Furue M.
  • Journal Title: Eur J Dermatol 18 Pages: 721-2
  • Peer Reviewed
• [Journal Article] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. (2008)
  • Author(s): Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Tu YT, Furue M, Moroi Y.
  • Journal Title: J Cutan Pathol 35 Pages: 722-30
  • Peer Reviewed
• [Journal Article] Successful treatment of nail bed hypoplasia following nail loss by acrylic nail. (2008)
  • Author(s): Dainichi T, Omori M, Hamada M, Hosokawa C, Moroi Y, Hashomoto T, Furue M.
  • Journal Title: Dermatol Surg 34 Pages: 984-5
  • Peer Reviewed
• [Journal Article] Excellent clinical results with a new preparation for chemical peeling in acne : 30% salicylic acid in polyethylene glycol vehicle. (2008)
  • Author(s): Dainichi T, Ueda S, Imayama S, Furue M.
  • Journal Title: Dermatol Surg 34 Pages: 891-9
  • Peer Reviewed
• [Journal Article] Vitiligo onset removes congenital nevocellular nevus cells. (2008)
  • Author(s): Dainichi T, Moroi Y, Urabe K, Hashimoto T, Furue M.
  • Journal Title: J Dermatol Sci 51 Pages: 66-9
  • NAID: 10024119496
  • Peer Reviewed
• [Journal Article] By the grace of peeling : the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis. (2008)
  • Author(s): Dainichi T, Ueda S, Furue M, Hashimoto T.
  • Journal Title: Arch Dermatol Res 300
  • Peer Reviewed
• [Journal Article] Clavus detected incidentally by positron emission tomography with computed tomography. (2008)
  • Author(s): Dainichi T, Honma Y, Hashimoto T, Furue M.
  • Journal Title: J Dermatol 35 Pages: 242-3
  • NAID: 10021942058
  • Peer Reviewed
• [Journal Article] Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinoma and eccrine poroma. (2008)
  • Author(s): Chen SY, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Furue M, Moroi Y, Tu YT.
  • Journal Title: J Dermatol Sci 49 Pages: 170-3
  • NAID: 10024118730
  • Peer Reviewed
• [Journal Article] By the grace of peeling : the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis (2008)
  • Author(s): Dainichi, T, et.al.
  • Journal Title: Arch Dermatol Res 300
  • Peer Reviewed
• [Journal Article] Excellent clinical Tesults with a new preparation for chemical peeling inacne : 30% salicylic acid in polyethylene glycol vehicle (2008)
  • Author(s): Dainichi T, et.al.
  • Journal Title: Dermatol Surg 34 Pages: 891-899
  • Peer Reviewed
• [Journal Article] Paraneoplastic acanthosis nigricans and silent meningioma producing transforming growth factor-alpha (2008)
  • Author(s): Dainichi T, et.al.
  • Journal Title: Eur J Dermatol 18 Pages: 721-722
  • Peer Reviewed
• [Journal Article] Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma (2008)
  • Author(s): Chen SY, Takeuchi S, Urabe K, Hayashida S, Kido M, Tomoeda H, Uchi H, Dainichi T. Takahara M, Shibata S. Tu YT, Furue M, Moroi Y
  • Journal Title: J Cutan Pathol 35 Pages: 722-730
  • Peer Reviewed
• [Journal Article] Vitiligo onset removes congenital nevocellular nevus cells (2008)
  • Author(s): Dainichi T, et.al.
  • Journal Title: J Dermatol Sci 51 Pages: 66-69
  • NAID: 10024119496
  • Peer Reviewed
• [Journal Article] Clavus detected incidentally by positron emission tomography with computed tomography (2008)
  • Author(s): Dainichi T, et.al.
  • Journal Title: J Dermatol 35 Pages: 242-243
  • NAID: 10021942058
  • Peer Reviewed
• [Journal Article] Successful treatment of nail bed hypoplasia after nail loss by acrylic nail (2008)
  • Author(s): Dainichi T, et.al.
  • Journal Title: Dermatol Surg 34 Pages: 984-985
  • Peer Reviewed
• [Journal Article] By the grace of peeling: the brace function of the stratum comeum in theprotection from photo-induced keratinocyte carcinogenesis (2008)
  • Author(s): Dainichi T, Ueda S, Furue M, Hashimoto T
  • Journal Title: Arch Dermatol Res 300 Pages: 31-38
  • Peer Reviewed
• [Journal Article] Overexpression of phosphorylated ATF2 and STAT3 in eccrine porocarcinomaand eccrine poroma. (2008)
  • Author(s): Chen SY, Takeuchi S, Urabe K, Kido M, Hayashida S, Tomoeda H, Uchi H, Dainichi T, Takahara M, Shibata S, Furue M, Moroi Y, TuYT
  • Journal Title: J Dermatol Sci 49 Pages: 170-173
  • Peer Reviewed
• [Journal Article] Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. (2008)
  • Author(s): Liu H, Takeuchi S, Moroi Y, Lin N, Urabe K, Kokuba H, lmafuku S, Dainichi T, Uchi H, Furue M, Tu Y.
  • Journal Title: Int J Dermatol 46 Pages: 1171-1176
  • Peer Reviewed
• [Journal Article] Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. (2007)
  • Author(s): Liu H, Takeuchi S, Moroi Y, Lin N, Urabe K, Kokuba H, Imafuku S, Dainichi T, Uchi H, Furue M, Tu Y.
  • Journal Title: Int J Dermatol 46 Pages: 1171-6
  • Peer Reviewed
• [Journal Article] Interdigital amelanotic spindle-cell melanomamimicking an inflammatory process due to dermatophytosis. (2007)
  • Author(s): Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M, Furue M.
  • Journal Title: J Dermatol 34 Pages: 716-9
  • NAID: 10021306585
  • Peer Reviewed
• [Journal Article] Significance of the expression of phosphorylated signal transducer and activator of transcription-3, -Akt, and -cyclin D1 in angiosarcoma. (2007)
  • Author(s): Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K.
  • Journal Title: Dermatol Sci 48 Pages: 64-6
  • NAID: 10024117388
  • Peer Reviewed
• [Journal Article] Significance of the expression of phosphorylated-STAT3, -Akt, and -ERK1/2 in several tumors of the epidermis. (2007)
  • Author(s): Lin N, Moroi Y, Uchi H, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K.
  • Journal Title: J Dermatol Sci 48 Pages: 71-3
  • NAID: 10024117403
  • Peer Reviewed
• [Journal Article] Cutaneous reactions induced by pegylated-interferon plus ribavirin combination therapy in a patient with chronic hepatitis C. (2007)
  • Author(s): Enjoji M, Dainichi T, Gondo H, Urabe K.
  • Journal Title: Fukuoka Igaku Zasshi 98 Pages: 353-6
  • NAID: 120000987980
  • Peer Reviewed
• [Journal Article] Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis. (2007)
  • Author(s): Dainichi T, Kobayashi C, Fujita S, Shiramizu K, Ishiko T, Kiryu H, Urabe K, Tsuneyoshi M, Fume M.
  • Journal Title: J Dermatol 34 Pages: 716-719
  • NAID: 10021306585
  • Peer Reviewed
• [Journal Article] Significance of the express ion of phosphorylated signal transducer and activatorof traiiscription-3, -Akt, arid -cyclin D1 in angiosarcoma. (2007)
  • Author(s): Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Fmnie M, Urabe K.
  • Journal Title: J Dermatol Sci 48 Pages: 64-66
  • Peer Reviewed
• [Journal Article] Significance of the expression of phosphorylated-STAT3, -Akt, and -ERK1/2 in several tumors of the epidermis. (2007)
  • Author(s): Lin N, Moroi Y, Uchi H, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Fume M, Urabe K.
  • Journal Title: J Dermatol Sci 48 Pages: 71-73
  • NAID: 10024117403
  • Peer Reviewed
• [Journal Article] Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: what causes the diversity? (2007)
  • Author(s): Dainichi T, Uchi H, Moroi Y Furue M.
  • Journal Title: Dermatology 215 Pages: 86-88
  • Peer Reviewed
• [Journal Article] Expression and prognostic significance of Stat5a and E-cadherin in extramammary Paget's disease. (2007)
  • Author(s): Liu H, Urabe K, Uchi H, Takeuchi S, Nakahara T, Dainichi T, TuY Furue M, Moroi Y.
  • Journal Title: J Cutan Pathol 34 Pages: 33-38
  • Peer Reviewed
• [Journal Article] Expression of the p38 MAPK, NF-kappaB and cyclin D1 in extramammary Paget's disease. (2007)
  • Author(s): Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, UrabeK.
  • Journal Title: J Dermatol Sci 45 Pages: 187-192
  • Peer Reviewed
• [Journal Article] C型慢性肝炎に対するペグインターフェロン+リハビリン併用療法における副作用としての皮膚症状 (2007)
  • Author(s): 遠城寺宗近、大日輝記、権藤寿喜、占部和敬
  • Journal Title: 福岡医学雑誌 98 Pages: 353-356
  • Peer Reviewed
• [Journal Article] サリチル酸マクロゴールピーリングによるざ瘡の治療効果 (2007)
  • Author(s): 大日輝記、上田説子
  • Journal Title: Aesthetic Dermatol 17 Pages: 59-67
  • Peer Reviewed
• [Journal Article] 神経線維腫瘤V型に続発した悪性神経鞘腫. (2007)
  • Author(s): 藤田尚平、土井和子、大日輝記、増田禎一、師井洋一、占部和敬、古注増隆、今福信一.
  • Journal Title: 皮膚病診療 29 Pages: 269-72
  • Peer Reviewed
• [Journal Article] Skin tightening effect by a fractional laser treatment I : A randomized half-side pilot study on faces of acne patients.
  • Author(s): Dainichi T, Kawaguchi A, Ueda S, Tajiri R, Fumimori T, Kakuta T, Hashimoto T.
  • Journal Title: Dermatol Surg (in press)
  • Peer Reviewed
• [Journal Article] Skin tightening effect by a fractional laser treatment II: a pilot animal study on skin remodeling.
  • Author(s): Dainichi T, Ueda S, Fumimori T, Kiryu H, Hashimoto T.
  • Journal Title: Dermatol Surg (in press)
  • Peer Reviewed
• [Journal Article] Phototherapy for mycosis fungoides in a patient with coincident systemic lupus erythematosus.
  • Author(s): Nakamura A, Dainichi T, Tomoeda H, Moroi Y, Urabe K, Furue M, Uenotsuchi T.
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Birt-Hogg-Dube syndrome with clear-cell and oncocytic renal tumour and trichoblastoma associated with a novel FLCN mutation.
  • Author(s): Imada K, Dainichi T, Yokomizo A, Tsunoda T, Song YH, Nagasaki A, Sawamura D, Nishie W, Shimizu H, Fukagawa S, Urabe K, Furue M, Hashimoto T, Naito S.
  • Journal Title: Br J Dermatol (in press)
  • Peer Reviewed
• [Journal Article] A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine.
  • Author(s): Tanaka N, Dainichi T, Ohyama B, Yashumoto S, Oono T, Iwatsuki K, Elfert S, Fritsch A, Bruckner-Tuderman L, Hashimoto T.
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Journal Article] Refractory oral ulcers with multiple IgG/IgA autoantibodies without skin lesions.
  • Author(s): Dainichi T, Ohyama B, Ishii N, Yamaguchi Z, Yasumoto S, Hashimoto T
  • Journal Title: J Am Acad Dermatol (in press)
  • Peer Reviewed
• [Presentation] 薬疹と遺伝 (2008)
  • Author(s): 大日輝記
  • Organizer: 第107回日本皮膚科学会総会・学術大会教育講演
  • Place of Presentation: 京都市
• [Presentation] Autoantigen in anti-p200 pemphigoid. (2008)
  • Author(s): Dainichi T, Kurono S, Ohyama B, Ishii N, Hayashi M, Shimono C, Taniguchi Y, Sanzen N, Karashima T, Yasutomo S, Sekiguchi K, Zillikens D, Hashimoto T.
  • Organizer: 2008 International Meeting on Autoimmune Bullous Diseases, Invited Lecture.
  • Place of Presentation: Otsu, Japan
• [Presentation] フラクショナルレーザーによるフェイスリフト効果 (2008)
  • Author(s): 大日輝記、上田説子、田尻力也、文森健明、桐生美麿、橋本隆.
  • Organizer: 26回日本美容皮膚科学会総会・学術大会
  • Place of Presentation: 大阪市
• [Presentation] アトピー性皮膚炎に対するケミカルピーリングの効果 (2008)
  • Author(s): 大日輝記、上田説子、古江増隆、橋本隆.
  • Organizer: 第20回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京都
• [Presentation] Laminin-gamma1 is a major autoantigen in anti-p200 pemphigoid. (2008)
  • Author(s): Dainichi T. Kurono S, Ohyama B, Ishii N, Hayashi M, Shimono C, Taniguchi Y, Sanzen N, Karashima T, Yasutomo S, Sekiguchi K, Zillikens D, Hashimoto T.
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Kyoto, Japan.
• [Presentation] フラクショナルレーザーによるフェイスリフト効果 (2008)
  • Author(s): 大日輝記、他
  • Organizer: 第26回日本美容皮膚科学会総会・学術大会
  • Place of Presentation: 東京都
• [Presentation] Autoantigen in and-p200 pemphigoid (2008)
  • Author(s): Dainichi T, et.al.
  • Organizer: 2008 International Meeting on Autoimmune Bullous Diseases, Invited Lecture
  • Place of Presentation: Otsu, Japan
• [Presentation] Laminin-2ammal is a major autoantigen in and-p200 pemphigoid (2008)
  • Author(s): Dainichi T, et.al.
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: Kyoto, Japan
• [Presentation] 天疱瘡におけるTh17の免疫組織化学的評価. (2007)
  • Author(s): 荒川正崇、大日輝記、橋本隆.
  • Organizer: 第11会九州基礎皮膚科研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-12-08
• [Presentation] VII型コラーゲンに反応し、コルヒチンが著効したBrunsting-Perry型類天疱瘡様後天性表皮水疱症. (2007)
  • Author(s): 田中倫子、大山文悟、大日輝記、安元慎一郎、橋本隆、大野貴司、岩月啓氏.
  • Organizer: 第59回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 宮崎市
• [Presentation] Chemical peeling normalizes keratinization and suppresses pre-malignant change in photo-damaged skin. (2007)
  • Author(s): Dainichi T, Amano S, Matsunaga Y, Iriyama S, Hirao T, Hariya T, Hibino T, Katagiri C, Takahashi M, Ueda S, Hashimoto T, Furue M.
  • Organizer: 68th Annual Meeting of the Soociety for Investigative Dermatology.
  • Place of Presentation: Los Angeles, USA
• [Presentation] 皮膚バリア機能および免疫応答におけるカテプシンEの役割. (2007)
  • Author(s): 大日輝記、城戸真希子、筑波隆幸、山本健二、古江増隆.
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Presentation] Birt-Hogg-Dube症候群と考えた症例 (2007)
  • Author(s): 大日輝記、今田憲二郎、角田俊之、澤村大輔、占部和敬、古江増隆.
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Presentation] 全身性エリテマトーデスに菌状息肉症を併発し、光線療法が奏功した1例. (2007)
  • Author(s): 中村暁子、友枝裕人、大日輝記、上ノ土武、師井洋一、古江増隆.
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Presentation] アトピー性皮膚炎へのサリチル酸マクロゴールピーリング 角層正常化による側面より. (2007)
  • Author(s): 大日輝記
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Presentation] VII型コラーゲンに反応し、コルヒチンが著効したBrunsting-Perry型類天疱瘡様後天性表皮水痘症 (2007)
  • Author(s): 田中倫子、大山文悟、大日輝記、安元慎一郎、橋本隆、大野貴司、岩月啓氏.
  • Organizer: 第59回日本皮膚科学会西部支部学術大会
  • Place of Presentation: 宮崎市
• [Presentation] Chemical peeling normalizes keratinization and suppresses pre-maligant change in photo-damaged skin (2007)
  • Author(s): Dainichi T, Amano S, Matsunaga Y, Iriyama S, Hirao T, Hariya T, Hibino T, Katagiri C, Takahashi M, Ueda S, Hashimoto T, Fiirue M.
  • Organizer: 68th Annual Meeting of the Soociety for Investigative Dermatology
  • Place of Presentation: Los Angeles, USA
• [Presentation] Birt-Hogg-Dube症候群と考えた症例. (2007)
  • Author(s): 大日輝記、今田憲二郎、角田俊之、澤村大輔、占部和敬、古注増隆.
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Presentation] アトピー性皮膚炎へのサリチル酸マクロゴールヒーリング 角層正常化による側面より. (2007)
  • Author(s): 大日輝記
  • Organizer: 第106回日本皮膚科学会総会・学術大会
  • Place of Presentation: 横浜市
• [Book] マウスからのメッセージ.ケミカルピーリング これが私のコツと技.(2009年2版.古川福実、船坂陽子、上田説子編.) (2009)
  • Author(s): 大日輝記
  • Publisher: 南山堂
• [Book] 美容治療は皮膚癌の発生を予防できるか?(Monthly Book Derma増刊号・メスを使わない美容治療実践マニュアル.山本有紀編.) (2008)
  • Author(s): 大日輝記
  • Publisher: 全日本病院出版会
• [Book] 美容治療は皮膚癌の発生を予防できるか?Monthly Book Derma増刊号・メスを使わない美容治療実践マニュアル.山本有紀編 (2008)
  • Author(s): 大日輝記
  • Total Pages: 5
  • Publisher: 全日本病院出版会
• [Book] ケミカルピーリングによる角化の正常化(WHAT'S NEW in 皮膚科学.宮地良樹編.) (2007)
  • Author(s): 大日輝記
  • Publisher: メディカルレビュー社
• [Book] ケミカルピーリングによる角化の正常化.(What's New in皮膚科学2008-2009) (2007)
  • Author(s): 大日輝記
  • Total Pages: 2226
  • Publisher: メディカルレビュー社
• [Remarks]
  • URL: http://www.med.kurume-u.ac.jp/med/derm/index.htm
• [Remarks]
  • URL: http://www.med.kurume-u.ac.jp/med/derm/index.htm
• [Remarks]
  • URL: http://www.med.kurume-u.ac.jp/med/derm/