Differentiation-induction therapy with adipocytokine for cutaneous squamous cell carcinoma

• Project/Area Number: 19790791
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Saga University
• Principal Investigator: INOUE Takuya Saga University, 医学部, 講師 (50380754)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 皮膚腫瘍学 / 分化誘導療法 / 皮膚癌 / adiponectin / adionectin / adipocytokine

Research Abstract

We have shown that subcutaneous adipocytes of rats facilitate the differentiation of squamous cell carcinoma cells of the skin in vitro. We hypothesized that adipocyte-derived cytokines have a promoting effect on differentiation of carcinoma cells. We examined the effect of adiponectin on squamous cell carcinoma cells of the skin and investigated the role of adipocytokine on the growth and differentiation of the cancer cells.