The effects of sonic hedgehog on lymphangiogenesis in impaired wound healing

• Project/Area Number: 19790795
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ASAI Jun Kyoto Prefectural University of Medicine, 医学研究科, 助教 (50438222)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 皮膚生理学 / 皮膚潰瘍 / ヘッジホッグ / リンパ管 / マクロファージ

Research Abstract

ヘッジホッグがマクロファージを介したリンパ管新生を促進することを示した。その機序として、マクロファージ自身のリンパ管内皮細胞への分化を誘導することが明らかになった。ソニックヘッジホッグがリンパ管新生を介した難治性皮膚潰瘍の新しい治療法として有効な治療法となる可能性が示唆された。

Research Products

• [Journal Article] Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir. (2009)
  • Author(s): Daito J, Hanada K, Katoh N, Katoh S, Sakamoto K, Asai J, Takenaka H, Kishimoto S.
  • Journal Title: Dermatology 218(1) Pages: 60-2
  • Peer Reviewed
• [Journal Article] Symmetrical drug-related intertriginous and flexural exanthema caused by valacyclovir (2009)
  • Author(s): J Daito, et.al.
  • Journal Title: Dermatology 218(1) Pages: 60-62
  • Peer Reviewed
• [Journal Article] Brunsting-Perry cicatricial pemphigoid associated with autoantibodies to the C-terminal domain of BP180. (2008)
  • Author(s): Daito J, Katoh N, Asai J, Ueda E, Takenaka H, Ishii N, Hashimoto T, Kishimoto S.
  • Journal Title: Br J Dermatol 159(4) Pages: 984-6
  • Peer Reviewed
• [Journal Article] Brunsting-Perry cicatricial pemphigoid associated with autoantibodies to the C-terminal domain of BP180 (2008)
  • Author(s): J Daito, et.al.
  • Journal Title: British Journal of Dematology 159(4) Pages: 984-986
  • Peer Reviewed
• [Journal Article] Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. (2007)
  • Author(s): Maruyama K, Asai J (co-first author), Ii M, Thorne T, Losordo DW, D'Amore PA.
  • Journal Title: Am J Pathol 170(4) Pages: 1178-91
  • Peer Reviewed
• [Journal Article] Kishimoto S. Infantile myofibromatosis of the scrotum. (2007)
  • Author(s): Ichihashi K, Takenaka H, Asai J, Morihara K, Kimura O, Morishima Y, Katoh N,
  • Journal Title: Eur J Dermatol 18(1) Pages: 82-83
• [Journal Article] 創傷治癒のメカニズム骨髄由来細胞の寄与 (2007)
  • Author(s): 竹中秀也、浅井純、岸本三郎
  • Journal Title: 京津府立医大雑誌 116(9) Pages: 611-618
• [Journal Article] 創傷治癒と局所因子 (2007)
  • Author(s): 浅井純、竹中秀也.
  • Journal Title: MB Derma 129 Pages: 18-23
• [Journal Article] 難治性皮膚潰瘍-病態解明とあらたな治療戦略- (2007)
  • Author(s): 岸本三郎、浅井純、竹中秀也
  • Journal Title: .皮膚病診療 29 Pages: 253-259
• [Journal Article] 創傷治癒と局所因子 (2007)
  • Author(s): 浅井純、竹中秀也
  • Journal Title: MB Derma 129 Pages: 18-23
• [Journal Article] Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing (2007)
  • Author(s): Maruyama K, Asai J (co-first author)., et. al.
  • Journal Title: American Journal of Pathology 170(4) Pages: 1178-1191
  • Peer Reviewed
• [Journal Article] Infantile myofibromatosis of the scrotum (2007)
  • Author(s): Ichihashi K, Takenaka H, Asai J, et. al.
  • Journal Title: European Journal of Dermatology 18(1) Pages: 82-83
  • Peer Reviewed
• [Presentation] CXCR4-selective antagonist AMD3100 accelerates impaired wound healing in diabetic mice. (2009)
  • Author(s): Nishimura Y, Ii M, Asai J, Takenaka H, Katoh N, Hamada H, Qin G, Losordo DW, Kishimoto S.
  • Organizer: 69th Annual meeting of the Society for Investigative Dermatology(in press)
  • Place of Presentation: Montreal, Canada
• [Presentation] 皮膚遅延型接触過敏反応におけるリンパ管の機能解析 (2008)
  • Author(s): 浅井純
  • Organizer: 第107回日本皮膚科学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-04-19
• [Presentation] Losordo DW. Hedgehog signaling promotes lymphatic differentiation of macrophages (2007)
  • Author(s): Asai J, Maruyama K, Renault M, Ii M, Takenaka H, Thorne T, Kishimoto S,
  • Year and Date: 2007-12-07
• [Presentation] Topical P2Y12 purinoreceptor antagonists reduce inflammation in irritant and allergic contact dermatitis models (2007)
  • Author(s): Katoh N, Mineoka-Tamagawa R, Nara T, Soga F, Asai J, Masuda K, Kishimoto S.
  • Year and Date: 2007-12-07
• [Presentation] 創傷治癒におけるリンパ管新生 (2007)
  • Author(s): 浅井純
  • Organizer: 第58回日本皮膚科学会中部支部学術大会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-20
• [Presentation] Hedgehog signaling promotes Iymphatic differentiation of macrop hages (2007)
  • Author(s): Asai J, Maruyama K, et. al.
  • Organizer: Society for Investigative Dermatology 2007
  • Place of Presentation: Los Angels,CA,USA
• [Presentation] Topical P2Y12 purinoreceptor antagonists reduce inflammation in irritant and allergic contact dermatitis models (2007)
  • Author(s): Katoh N, Mineoka-Tamagawa R, Nara T, Soga F, Asai J, et. al.
  • Organizer: Society for Investigative Dermatology 2007
  • Place of Presentation: Los Angels, CA, USA
• [Book] Monthly Book Derma 2007年7月号 (2007)
  • Author(s): 浅井 純、竹中 秀也、 他
  • Total Pages: 88
  • Publisher: 全日本病院出版会
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/dermatol/index.htm