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Research on development of hyper IgE and dermatitis through Ttc7, the regulatory factor of an autoinflammatory disease

Research Project

Project/Area Number 19790798
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionWakayama Medical University

Principal Investigator

MIKITA Naoya  Wakayama Medical University, 医学部, 博士研究員 (60405462)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,940,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsflaky / Ttc7 / IgE / 皮膚炎 / flakvマウス
Research Abstract

Sufficient results have not been obtained by in vivo and ex vivo experiments using fsn mice, owing to MHV pollution in the SPF areas of the Wakayama Medical University Animal Facilities. Backcrossing BALB/c-fsn mice with C57BL/6 mice has been performed without revealing any obvious phenotype. On the other hand, the SNP analyses on human chronic dermatitis have shown a weak but significant association of a particular haplotype of the Ttc7a gene with psoriasis, rather than atopic dermatitis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (31 results)

  • [Journal Article] 古川福実. 日本人のハンセン病発症における細菌センサー分子TLR2・DC-SIGN・NOD1・NOD2の遺伝子多型の関与2009

    • Author(s)
      金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂眞紀、石井則久、西村泰行
    • Journal Title

      日本ハンセン病学会雑誌 78

      Pages: 255-261

    • Related Report
      2009 Final Research Report
  • [Journal Article] The protective effects of ultraviolet A1 irradiation on spontaneous lupus eryt hematosus-like skin lesions in MRL/lpr mice.2009

    • Author(s)
      Mikita N, Kanazawa N, Yoshimasu T, I keda T, Li HJ, Yamamoto Y, Furukawa F.
    • Journal Title

      Clinical Developmental Immunolo gy 673952

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] No involvement of non-synonymous TLR2 polymorphisms in Japanese lepros y patients.2009

    • Author(s)
      Mikita N, Kanazawa N, Ozaki M, Kosa ka M, Ishi N, Nishimura H, Furukawa F.
    • Journal Title

      Journal of Dermatological Sc ience 54

      Pages: 48-49

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F2009

    • Author(s)
      Mikita N, Kanazawa N
    • Journal Title

      No involvement of non-synonymous TLR2 in Japanese Ieprosy patients. Journal of Dermatological Science 54

      Pages: 48-49

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice.2009

    • Author(s)
      Mikita N, Kanazawa N, Yoshimasu T, Ikeda T, Li HJ, Yamamoto Y, Furukawa F
    • Journal Title

      Clinical Developmental Immunology 無

      Pages: 673952-673952

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人のハンセン病発症における細菌センサー分子TLR2・DC-SIGN・NOD1・NOD2の遺伝子多型の関与2009

    • Author(s)
      金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Journal Title

      日本ハンセン病学会雑誌 78

      Pages: 255-261

    • Related Report
      2009 Annual Research Report
  • [Journal Article] No involvement of non-synonymous TLR2 polymorphisms in Japanese leprosy patients.2009

    • Author(s)
      Mikita N, Kanazawa N, Ozaki M, Kosaka M, Ishii N, Nishimura H, F urukawa F
    • Journal Title

      Journal of Dermatological Science 54

      Pages: 48-49

    • NAID

      10025333204

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression of histamine receptors in skin lesions of MRL/MP-lpr/ lpr mice.2008

    • Author(s)
      Yoshimasu T, Kanazawa N, Mikita N, Furukawa F.
    • Journal Title

      Open Dermatology Journal 2

      Pages: 83-86

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of histamine receptors in skin lesions of MRL/MP1pr/lpr mice2008

    • Author(s)
      Yoshimasu T, Kanazawa N, Mikita N, Furukawa F
    • Journal Title

      Open Dermatology Journal 2

      Pages: 83-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果2010

    • Author(s)
      三木田直哉
    • Organizer
      第1回日本研究皮膚科学会きさらぎ塾
    • Place of Presentation
      沖縄県読谷村
    • Related Report
      2009 Final Research Report
  • [Presentation] MRL/1prマウスのエリテマトーデス様皮疹に対するUVA1照射の効果2010

    • Author(s)
      三木田直哉
    • Organizer
      第1回日本研究皮膚科学会きさらぎ塾
    • Place of Presentation
      沖縄県読谷村
    • Related Report
      2009 Annual Research Report
  • [Presentation] 和歌山県立医科大学附属病院皮膚科の病診連携報告その112009

    • Author(s)
      岡本勝行、土井直孝、下松達哉、石黒真理子、西山瑞穂、豊澤聖子、木村文子、三木田直哉、上中智香子、中村智之、池田高治、米井希、貴志知生、金澤伸雄、山本有紀、古川福実
    • Organizer
      第413回日本皮膚科学会大阪地方会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-05-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice.2009

    • Author(s)
      Furukawa F, Yamamoto Y, Mikita N, Kanazawa N, Yoshimasu T, Uede M.
    • Organizer
      The 4th Asian Congress on Autoimmunity
    • Place of Presentation
      シンガポール
    • Related Report
      2009 Final Research Report
  • [Presentation] The protective effects of ultraviolet A1 irradiation on spontaneous lupus erythematosus-like skin lesions in MRL/lpr mice.2009

    • Author(s)
      Yoshimasu T、Mikita N, Kanazawa N, Furukawa F.
    • Organizer
      The 69th Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      モントリオール
    • Related Report
      2009 Final Research Report
  • [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果2009

    • Author(s)
      三木田直哉、李洪錦、石黒真理子、池田高治、吉益隆、金澤伸雄、山本有紀、古川福実
    • Organizer
      第108回日本皮膚科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] MRL/lprマウスのエリテマトーデス様皮疹に対するUVA1照射の効果2009

    • Author(s)
      三木田直哉、李洪錦、石黒真理子、池田高治、吉益隆、金澤伸雄、山本有紀、古川福実
    • Organizer
      第412回日本皮膚科学会大阪地方会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] The protective effects of ultraviolet A1 irradiation on sponta-neous lupus erythematosus-like skin lesions in MRL/lpr mice2009

    • Author(s)
      Yoshimasu T、 Mikita N, Kanazawa N, Furukawa F
    • Organizer
      The 69th Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      モントリオール
    • Related Report
      2009 Annual Research Report
  • [Presentation] The protective effects of ultraviolet A1 irradiation on sponta-neous lupus erythematosus-like skin lesions in MRL/lpr mice2009

    • Author(s)
      Furukawa F, Yamamoto Y, Mikita N, Kanazawa N, Yoshimasu T, Uede M
    • Organizer
      The 4th Asian Congress on Autoimmunity
    • Place of Presentation
      シンガポール
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本のハンセン病における細菌センサー分子TLR2, DC-SIGN, NOD1, and NOD2の遺伝子的関与2008

    • Author(s)
      金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂眞紀、石井則久、古川福実
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] MRL/lprマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防的効果の検討2008

    • Author(s)
      三木田直哉、李洪錦、乾匡範、池田高治、吉益隆、金澤伸雄、古川福実
    • Organizer
      第38回日本免疫学会総会・学術大会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] MRL/lprマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防的効果の検討2008

    • Author(s)
      三木田直哉、李洪錦、池田高治、吉益隆、金澤伸雄、古川福実
    • Organizer
      第58回日本アレルギー学会秋期学術大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] アトピー性皮膚炎患者及び乾癬患者におけるTetratricopeptide repeat domain 7A遺伝子多型の検討2008

    • Author(s)
      三木田直哉、乾匡範、金澤伸雄、西村泰行、古川福実
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN, NOD1 and NOD2, in Japanese leprosy.2008

    • Author(s)
      Kanazawa N, Mikita N, Li H, Nakatani N, Ozaki M, Kosaka M, Ishii N, Furukawa F.
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] 細菌センサー分子TLR2・DC-SIGN・NOD2の遺伝子多型のハンセン病発症への関与2008

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、古川福実
    • Organizer
      第20回日本アレルギー学会春期臨床大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 細菌センサー分子tlr2・dc-si gn・nod2の遺伝子多型のハンセン病発症への関与2008

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第81回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      熊本
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of the Tetratricopeptide repeat domain 7 gene polymorphisms in Japanese psoriasis and atopic dermatitis patients.2008

    • Author(s)
      Mikita N, Inui M, Kanazawa N, Nishimura H, Furukawa F.
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN and NOD2, in Hansen's disease.2008

    • Author(s)
      Kanazawa N, Mikita N, Nakatani N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Familial Japanese fever (Nakajo-Nishimura syndrome): a novel hereditary periodic fever with partial lipodystrophy and a search for LPIN gene mutations.2008

    • Author(s)
      Kanazawa N, Mikita N, Furukawa F, Nishimura H, Kawano S, Matsunaka M, Koike M, Sugino H.
    • Organizer
      The Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases
    • Place of Presentation
      ローマ(イタリア)
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of the Tetratricopeptide repeat domain 7 gene polymorphisms in Japanese nsoriasis and atonic dermatitis natientc2008

    • Author(s)
      Mikita N, Inui M, Kanazawa N, Nishimura H, Furukawa F
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] The preventive effects of ultraviolet A-1 irradiation on spontaneous skin lesion of MRL/lpr mice2008

    • Author(s)
      Mikita N, Ikeda T, Yoshimasu T, Kanazawa N, Yamamoto Y, Furukawa F
    • Organizer
      8th Asian Dermatological Congress
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of dendrite cells on the preventive effect of ultraviolet A-lirradiation on lupus erythematosus-like skin lesions of MRL/lpr mice2008

    • Author(s)
      Mikita N, Li H, Ikeda T, Yoshimasu T, Kanazawa N, Furukawa F
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] アトピー性皮膚炎および乾癬患者におけるTetratricopeptide repeat domain 7A遺伝子多型の検討2008

    • Author(s)
      三木田直哉、乾匡範、金澤伸雄、西村泰行、古川福実
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] MRL/1prマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防的効果の検討2008

    • Author(s)
      三木田直哉、李洪錦、池田高治、吉益隆、金澤伸雄、古川福実
    • Organizer
      第58回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] MPRL/1prマウスのエリテマトーデス様皮膚症に対する紫外線UVA-1治療の予防2008

    • Author(s)
      三木田直哉、李洪錦、乾匡範、池田高治、吉益隆、金澤伸雄、古川福実
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハンセン病におけるTLR2遺伝子変異の検索2007

    • Author(s)
      三木田直哉、金澤伸雄、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第401回日本皮膚科学会大阪地方会和歌山地区会
    • Place of Presentation
      和歌山
    • Year and Date
      2007-05-26
    • Related Report
      2009 Final Research Report
  • [Presentation] ハンセン病におけるTLR2遺伝子変異の検索.2007

    • Author(s)
      三木田直哉、金澤伸雄、古川福実ほか
    • Organizer
      第401回日本皮膚科学会大阪地方会和歌山地区会
    • Place of Presentation
      和歌山
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease.2007

    • Author(s)
      Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
    • Organizer
      第37回日本免疫学会総会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease.2007

    • Author(s)
      Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
    • Organizer
      The 4th World Association of Sarcoidosis and Other Granulomatous Disorders
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] ハンセン病におけるTLR2遺伝子変異の検索2007

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第80回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] ハンセン病におけるTLR2遺伝子変異の検索2007

    • Author(s)
      三木田直哉、金澤伸雄、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第32回日本研究皮膚科学会学術大会・総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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