Research on development of hyper IgE and dermatitis through Ttc7, the regulatory factor of an autoinflammatory disease
| Project/Area Number |
19790798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MIKITA Naoya Wakayama Medical University, 医学部, 博士研究員 (60405462)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,940,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | flaky / Ttc7 / IgE / 皮膚炎 / flakvマウス |
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| Research Abstract |
Sufficient results have not been obtained by in vivo and ex vivo experiments using fsn mice, owing to MHV pollution in the SPF areas of the Wakayama Medical University Animal Facilities. Backcrossing BALB/c-fsn mice with C57BL/6 mice has been performed without revealing any obvious phenotype. On the other hand, the SNP analyses on human chronic dermatitis have shown a weak but significant association of a particular haplotype of the Ttc7a gene with psoriasis, rather than atopic dermatitis.
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Report
(4 results)
Research Products
(40 results)
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[Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN, NOD1 and NOD2, in Japanese leprosy.2008
Author(s)
Kanazawa N, Mikita N, Li H, Nakatani N, Ozaki M, Kosaka M, Ishii N, Furukawa F.
Organizer
The 10th International Symposium on Dendritic Cells
Place of Presentation
神戸
Related Report
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[Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN and NOD2, in Hansen's disease.2008
Author(s)
Kanazawa N, Mikita N, Nakatani N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F.
Organizer
International Investigative Dermatology 2008
Place of Presentation
京都
Related Report
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