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Regulation of dendritic cell functions with C-type lectin paired immunoreceptors,DCIR and DCAR

Research Project

Project/Area Number 19790800
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionWakayama Medical University

Principal Investigator

ANAZAWA Nobuo  Wakayama Medical University, 医学部, 講師 (90343227)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsDCIR / DCAR / 樹状細胞 / 皮膚
Research Abstract

In vitroの実験により、R&D社の抗DCIR抗体とBD社の33D1抗体はそれぞれDCIR1とDCIR2に特異的だが、R&D社の抗DCAR抗体はDCAR2とDCIR1の双方を認識することが判明した.従って現時点で手元にある抗体でマウスDCARを特異的に認識し刺激を導入する方法を確立できず、DCIRとDCARによる皮膚を場とする樹状細胞機能制御機構を明らかにすることはできなかった.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (42 results)

All 2009 2008 2007

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (24 results)

  • [Journal Article] No involvement of non-synonymous TLR2 polymorphisms in Japanese leprosy patients2009

    • Author(s)
      Mikita N, Kanazawa N, Ozaki M, Kosaka M, Ishi N, Nishimura H, Furukawa F
    • Journal Title

      Journal of Dermatological Science 54

      Pages: 48-49

    • NAID

      10025333204

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009

    • Author(s)
      Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T
    • Journal Title

      Arthritis and Rheumatism 60

      Pages: 242-250

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cutaneous polyarteritis nodosa : revisiting its definition and diagnostic criteria2009

    • Author(s)
      Nakamura T, Kanazawa N, Ikeda T, Yamamoto Y, Nakabayashi K, Ozaki S, Furukawa F
    • Journal Title

      Archives of Dermatological Research 301

      Pages: 117-121

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] No involvement of non-synonymous TLR2 polymorphisms in Japanese leprosy patients.2009

    • Author(s)
      Mikita N, Kanazawa N, Ozaki M, Kosaka M, Ishii N, Nishimura H. Furukawa F
    • Journal Title

      Journal of Dermatological Science 54

      Pages: 48-49

    • NAID

      10025333204

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009

    • Author(s)
      Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Mivachi Y, Nakahata T
    • Journal Title

      Arthritis and Rheumatism 60

      Pages: 242-250

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The expression of histamine receptors in skin lesions of MRL/MP-lpr/lpr mice2008

    • Author(s)
      Yoshimasu T, Kanazawa N, Mikita N, Furukawa F
    • Journal Title

      Open Dermatology Journal 2

      Pages: 83-86

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes2008

    • Author(s)
      Toyozawa S, Yamamoto Y, Nishide T, Kishioka A, Kanazawa N, Matsumoto Y, Kuroyanagi Y, Furukawa F. Case report
    • Journal Title

      Dermatology Online Journal 14

      Pages: 17-17

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for the diagnosis and treatment of scabies in Japan (second edition)2008

    • Author(s)
      Executive Committee of Guideline for the Diagnosis (Ishii N, Asahina A, Amagai M, Iijima M, Ishikawa O, Imamura H, Ooe M, Ohtaki N, Kato Y, Kanazawa N, Kamide R, Kanzaki T, Konohana A, Komoda M, Sugiyama N, Sekine M, Takezaki S, Tanaka M, Tamura N, Nagaoka Y, Nanko H, Hayashi M, Makigami K, Matsuda T, Yoshizumi J, Wada Y)
    • Journal Title

      Journal of Dermatology 35

      Pages: 378-393

    • NAID

      10024297175

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of histamine receptors in skin lesions of MRL/M13-1pr/lpr mice2008

    • Author(s)
      Yoshimasu T, Kanazawa N, Mikita N, Furukawa F
    • Journal Title

      Open Dermatology Journal 2

      Pages: 83-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case report : a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes2008

    • Author(s)
      Toyozawa S, Yamamoto Y, Nishide T, Kishioka A, Kanazawa N, Matsumoto Y, Kuroyanagi Y, Furukawa F
    • Journal Title

      Dermatology Online Journal 14

      Pages: 17-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoinflammatory syndromes with a dermatological perspective2007

    • Author(s)
      Kanazawa N, Furukawa F.
    • Journal Title

      Journal of Dermatology 34

      Pages: 601-618

    • NAID

      10023918786

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of PDGF-B in TCA-treated epidermal keratinocytes2007

    • Author(s)
      Yonei N, Kanazawa N, Ohtani T, Furukawa F, Yamamoto Y
    • Journal Title

      Archives of Dermatological Research 299

      Pages: 433-440

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disease-associate d mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells2007

    • Author(s)
      Fujisawa A, Kambe N, Saito M, Ni-shi komori R, Tanizaki H, Kanazawa N, A dachi S, Heike T, Sagara J, Suda T, N akahata T, Miyachi Y
    • Journal Title

      Blood 109

      Pages: 2903-2911

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cell immunorece ptors: C-type lectin receptors for pattern-recognition and signaling on antigen presenting cells2007

    • Author(s)
      Kanazawa N
    • Journal Title

      Journal of Dermatological Science 45

      Pages: 77-86

    • Related Report
      2008 Final Research Report
  • [Journal Article] C-type lectin receptors for pattern-recognition and signaling on antigen-presenting cells2007

    • Author(s)
      Kanazawa N
    • Journal Title

      Journal of Dermatological Science 45

      Pages: 77-86

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoinflammatory syndromes with a dermatological perspective2007

    • Author(s)
      Kanazawa N, Furukawa F
    • Journal Title

      Jotimal of Dermatology 34

      Pages: 601-618

    • NAID

      10023918786

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of PDGF B in TCA-treated epidermal keratinocytes.2007

    • Author(s)
      Yonei N, Kanazawa N, Ohtani T, Furukawa F, Yamamoto Y
    • Journal Title

      Archives of Dermatological Research 299

      Pages: 433-440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease-associated mutations in CIASl induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells2007

    • Author(s)
      Fujisawa A, Kambe N, SaitoM, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, HeikeT, Sagara J, Suda T, NakahataT, Miyachi Y
    • Journal Title

      Blood 109

      Pages: 2903-2911

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Blau症候群2008

    • Author(s)
      金澤伸雄
    • Organizer
      第1回自己炎症疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 日本のハンセン病における細菌センター分子TLR2,DC-SIGN, NOD1,NOD2 の遺伝子的関与.2008

    • Author(s)
      金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂真紀、石井則久、古川福実
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 家族性日本熱(中條-西村症候群):凍瘡様皮疹と限局性脂肪萎縮を伴う新しい遺伝性周期熱症候群2008

    • Author(s)
      金澤伸雄、古川福実、松中成浩、河野誠司、小池通夫、杉野禮俊、井田弘明
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年発症サルコイドーシス・Blau症候群とNOD2変異2008

    • Author(s)
      金澤伸雄、岡藤郁夫、西小森隆太
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN, NOD1 and NOD2, in Japanese leprosy2008

    • Author(s)
      Kanazawa N, Mikita N, Li H, Nakatani N, Ozaki M, Kosaka M, Ishii N, Furukawa F
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 細菌センサー分子TLR2・DC-SIGN・NOD2の遺伝子多型のハンセン病発症への関与2008

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、古川福実
    • Organizer
      第20回日本アレルギー学会春期臨床大会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 細菌センサー分子TLCR2・DC-SIGN・NOD2の遺伝子多型のハンセン病発症への関与2008

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第81回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      熊本
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules2008

    • Author(s)
      Kanazawa N, Mikita N, Nakatani N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F
    • Organizer
      TLR2, DC-SIGN and NOD2,in Hansen's disease. International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Autoinflammatory syndromes with a dermatological perspective2008

    • Author(s)
      Kanazawa N
    • Organizer
      The 2nd International Conference on Cutaneous Lupus Erythematosus
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 自己炎症疾患とIL-1受容体アンタゴニスト(IL-1Ra)療法2008

    • Author(s)
      金澤伸雄
    • Organizer
      第107回日本皮膚科学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Familial Japanese fever (Nakajo-Nishimura syndrome): a novel hereditary periodic fever with partial lipodystrophy and a search for LPIN gene mutations2008

    • Author(s)
      Kanazawa N, Mikita N, Furukawa F, Nishimura H, Kawano S, Matsunaka M, Koike M, Sugino H
    • Organizer
      The Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases
    • Place of Presentation
      ローマ(イタリア)
    • Related Report
      2008 Final Research Report
  • [Presentation] Familial Japanese fever (Nakajo-Nishimura syndrome) : a novel hereditary periodic fever with partial lipodystrophy and a search for LPIN gene mutations2008

    • Author(s)
      Kanazawa N, Mikita N, Furukawa F, Nishimura H, Kawano S, Matsunaka M, Koike M, Sugino H
    • Organizer
      The Fifth International Congress on Familial Mediterranean Fever and Systemic Autoinflammatory Diseases
    • Place of Presentation
      ローマ(イタリア)
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN and NOD2, in Hansen's disease2008

    • Author(s)
      Kanazawa N, Mikita N, Nakatani N, Ozaki M, Kosaka M, Ishii N, Nishimura H. Furukawa F
    • Organizer
      International Investigative Dermatology 2008
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic involvement of bacterial sensor molecules, TLR2, DC-SIGN, NODI and NOD2, in Japanese leprosy2008

    • Author(s)
      Kanazawa N, Mikita N, Li H, Nakatani N, Ozaki M, Kosaka M, Ishii N, Furukawa F
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細菌センサー分子TLR2・DC-SIGN・NOD2の遺伝子多型のハンセン病発症への関与2008

    • Author(s)
      金盤雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第81回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      熊本
    • Related Report
      2008 Annual Research Report
  • [Presentation] 家族性日本熱(中條-西村症候群) : 凍瘡様皮疹と限局性脂肪萎縮を伴う新しい遺伝性周期熱症候群2008

    • Author(s)
      金澤伸雄、古川福実、松中成浩、河野誠司、小池通夫、杉野禮俊、井田弘明
    • Organizer
      第38回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 日本のハンセン病における細菌センター分子TLR2, DC-SIGN, NOD1, NOD2の遺伝子的関与2008

    • Author(s)
      金澤伸雄、三木田直哉、李洪錦、中谷友美、尾崎元昭、小坂真紀、石井則久、古川福実
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease2007

    • Author(s)
      Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F
    • Organizer
      The 4th World Association of Sarcoidosis and Other Granulomatous Disorders
    • Place of Presentation
      東京
    • Year and Date
      2007-10-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年発症サルコイドーシスの臨床像とNOD2遺伝子変異の相関2007

    • Author(s)
      金澤伸雄、岡藤郁夫、谷崎英昭、神戸直智、西小森隆太、中畑龍俊、宮地良樹
    • Organizer
      第44回日本臨床分子医学会学術集会
    • Place of Presentation
      和歌山
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] ハンセン病におけるTLR2遺伝子変異の検索2007

    • Author(s)
      金澤伸雄、三木田直哉、尾崎元昭、小坂眞紀、石井則久、西村泰行、古川福実
    • Organizer
      第80回日本ハンセン病学会総会・学術大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] ハンセン病の免疫学・分子生物学2007

    • Author(s)
      金澤伸雄
    • Organizer
      第106回日本皮膚科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 家族性日本熱(中条-西村症候群):限局性脂肪萎縮を伴う新しい遺伝性周期熱症候群とLPIN遺伝子の解析2007

    • Author(s)
      金澤伸雄、米井希、河野誠司、西村泰行、古川福実、樋口隆造、飯塚忠史、小池通夫、松中成浩、杉野禮俊
    • Organizer
      第32回日本研究皮膚科学会学術大会・総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Analysis of TLR2 gene polymorphisms in Hansen's disease.2007

    • Author(s)
      Kanazawa N, Mikita N, Ozaki M, Kosaka M, Ishii N, Nishimura H, Furukawa F
    • Organizer
      The 4th World Association of Sarcoidosis and Other Granulomatous Disorders
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] サルコイド様類上皮細胞肉芽腫からなるアレルギー性ピアス肉芽腫2007

    • Author(s)
      金澤 伸雄、 西山 瑞穂、 山本 有紀、 古川 福実
    • Organizer
      第37回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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