Investigation on the mechanism underlying suppression of contact hypersensitivity in grafted skin.

• Project/Area Number: 19790810
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YOSHIKI Ryutaro University of Occupational and Environmental Health, Japan, 医学部, 助教 (30412646)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 接触皮膚炎 / 植皮 / 免疫抑制 / ランゲルハンス細胞 / 調節性T細胞 / RANKL / IL-10 / サイトカイン / Lanerhans細胞

Research Abstract

皮膚科および形成外科領域において植皮術は手術などで欠損した皮膚をふさぐのにしばしば用いられる方法のひとつである。植皮を行われた部分では、いわゆる「かぶれ」が成立しにくいことを我々皮膚科医はしばしば経験していたが、その詳しい機序はわかっていなかった。今回の研究において、植皮部では皮膚の防衛機能の一つを担っている「ランゲルハンス細胞」の機能が変化し、「かぶれ」を起こしにくくする細胞を誘導することが明らかとなった。

Research Products

• [Journal Article] IL-10-producing Langerhans Cells and Regulatory T cells are Responsible for Depressed Contact Hypersensitivity in Grafted Skin. (2009)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Tokura Y
  • Journal Title: J Invest Dermatol. 129 Pages: 705-713
  • Peer Reviewed
• [Journal Article] IL-10-Producing Langerhans Cells and Regulatory T Cells Are Responsible for Depressed Contact Hypersensitivity in Grafted Skin (2009)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Tokura Y
  • Journal Title: Journal of Investigative Dermatology 129 Pages: 705-713
  • Peer Reviewed
• [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugito K and Tokura Y
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-12-03
• [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugita K and Tokura Y
  • Organizer: The 10^<th> International Symposium on Dendriti c Cells
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2008-10-01
• [Presentation] 低用量UVB照射による皮膚樹状細胞の変化 (2008)
  • Author(s): 吉木竜太郎, 杉田和成, 椛島健治, 戸倉新樹
  • Organizer: 第30回日本光医学・光生物学会
  • Place of Presentation: 島根県松江市
  • Year and Date: 2008-07-11
• [Presentation] R Increased epidermal RANKL of grafted skin induces IL-10-producing Langerhans cells and regulatory T cell tolerogenic for contact hypersensitivity (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
  • Organizer: The 5^<th> International Investigative Dermatology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2008-05-17
• [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression. (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugita K and Tokura Y
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
• [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression. (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugita K and Tokura Y
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe
• [Presentation] Increased epidermal RANKL of grafted skin induces IL-10-producing Langerhans cells and regulatory T cells tolerogenic for contact hypersensitivity (2008)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
  • Organizer: The 5th International Investigative Dermatology
  • Place of Presentation: Kyoto
• [Presentation] 低用量UVB照射による皮膚樹状細胞の変化 (2008)
  • Author(s): 吉木竜太郎 杉田和成 椛島健治 戸倉新樹
  • Organizer: 第30回日本光医学・光生物学会
  • Place of Presentation: 島根県
• [Presentation] Hyposensitization Through Grafted Skin Is Mediated by interleukin-10-producing Langerhans Cells and Regulatory T Cells (2007)
  • Author(s): Ryutaro Yoshiki
  • Organizer: 第37面日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] 低用量UVB照射による皮膚樹状細胞の機能及び形態変化 (2007)
  • Author(s): 吉木竜太郎 杉田和成 椛島健治 戸倉新樹
  • Organizer: 第34回皮膚かたち研究学会
  • Place of Presentation: 鳥取県
  • Year and Date: 2007-11-03
• [Presentation] Hyposensitization Through Grafted Skin Is Mediated by interleukin-10-producing Langerhans Cells and Regulatory T Cells (2007)
  • Author(s): Ryutaro Yoshiki
  • Organizer: European Society for Dermatological research
  • Place of Presentation: スイス、チューリッヒ
  • Year and Date: 2007-09-08
• [Presentation] skin induces IL-10-producing Langerhans cells and regulatory T cells tolerogenic for contact hypersensitivity. (2007)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
  • Organizer: 37th Annual ESDR Meeting
  • Place of Presentation: Zurich, Switzerland
• [Presentation] 経植皮部感作による接触過敏症の低反応性における制御性T細胞の介在 (2006)
  • Author(s): 吉木竜太郎 杉田和成 新健治 島内隆寿 椛島健治 戸倉新樹
  • Organizer: 日本研究皮膚科学会第31回年次学術大会・総会
  • Place of Presentation: 京都