• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation on the mechanism underlying suppression of contact hypersensitivity in grafted skin.

Research Project

Project/Area Number 19790810
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

YOSHIKI Ryutaro  University of Occupational and Environmental Health, Japan, 医学部, 助教 (30412646)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords接触皮膚炎 / 植皮 / 免疫抑制 / ランゲルハンス細胞 / 調節性T細胞 / RANKL / IL-10 / サイトカイン / Lanerhans細胞
Research Abstract

皮膚科および形成外科領域において植皮術は手術などで欠損した皮膚をふさぐのにしばしば用いられる方法のひとつである。植皮を行われた部分では、いわゆる「かぶれ」が成立しにくいことを我々皮膚科医はしばしば経験していたが、その詳しい機序はわかっていなかった。今回の研究において、植皮部では皮膚の防衛機能の一つを担っている「ランゲルハンス細胞」の機能が変化し、「かぶれ」を起こしにくくする細胞を誘導することが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (15 results)

All 2009 2008 2007 2006

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (13 results)

  • [Journal Article] IL-10-producing Langerhans Cells and Regulatory T cells are Responsible for Depressed Contact Hypersensitivity in Grafted Skin.2009

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Tokura Y
    • Journal Title

      J Invest Dermatol. 129

      Pages: 705-713

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-10-Producing Langerhans Cells and Regulatory T Cells Are Responsible for Depressed Contact Hypersensitivity in Grafted Skin2009

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Tokura Y
    • Journal Title

      Journal of Investigative Dermatology 129

      Pages: 705-713

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugito K and Tokura Y
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K and Tokura Y
    • Organizer
      The 10^<th> International Symposium on Dendriti c Cells
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 低用量UVB照射による皮膚樹状細胞の変化2008

    • Author(s)
      吉木竜太郎, 杉田和成, 椛島健治, 戸倉新樹
    • Organizer
      第30回日本光医学・光生物学会
    • Place of Presentation
      島根県松江市
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] R Increased epidermal RANKL of grafted skin induces IL-10-producing Langerhans cells and regulatory T cell tolerogenic for contact hypersensitivity2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
    • Organizer
      The 5^<th> International Investigative Dermatology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression.2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K and Tokura Y
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] RANKL from Apoptotic Keratinocytes And IL-10-producing Langerhans Cells Play Critical Roles for UVB Induced Immunosuppression.2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K and Tokura Y
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      Kobe
    • Related Report
      2008 Final Research Report
  • [Presentation] Increased epidermal RANKL of grafted skin induces IL-10-producing Langerhans cells and regulatory T cells tolerogenic for contact hypersensitivity2008

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
    • Organizer
      The 5th International Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Related Report
      2008 Final Research Report
  • [Presentation] 低用量UVB照射による皮膚樹状細胞の変化2008

    • Author(s)
      吉木竜太郎 杉田和成 椛島健治 戸倉新樹
    • Organizer
      第30回日本光医学・光生物学会
    • Place of Presentation
      島根県
    • Related Report
      2008 Final Research Report
  • [Presentation] Hyposensitization Through Grafted Skin Is Mediated by interleukin-10-producing Langerhans Cells and Regulatory T Cells2007

    • Author(s)
      Ryutaro Yoshiki
    • Organizer
      第37面日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低用量UVB照射による皮膚樹状細胞の機能及び形態変化2007

    • Author(s)
      吉木竜太郎 杉田和成 椛島健治 戸倉新樹
    • Organizer
      第34回皮膚かたち研究学会
    • Place of Presentation
      鳥取県
    • Year and Date
      2007-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Hyposensitization Through Grafted Skin Is Mediated by interleukin-10-producing Langerhans Cells and Regulatory T Cells2007

    • Author(s)
      Ryutaro Yoshiki
    • Organizer
      European Society for Dermatological research
    • Place of Presentation
      スイス、チューリッヒ
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] skin induces IL-10-producing Langerhans cells and regulatory T cells tolerogenic for contact hypersensitivity.2007

    • Author(s)
      Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T and Yoshiki Tokura
    • Organizer
      37th Annual ESDR Meeting
    • Place of Presentation
      Zurich, Switzerland
    • Related Report
      2008 Final Research Report
  • [Presentation] 経植皮部感作による接触過敏症の低反応性における制御性T細胞の介在2006

    • Author(s)
      吉木竜太郎 杉田和成 新健治 島内隆寿 椛島健治 戸倉新樹
    • Organizer
      日本研究皮膚科学会第31回年次学術大会・総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi