Function of lymphatics in cutaneous immunity

• Project/Area Number: 19790811
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: SUGAYA Makoto The University of Tokyo, 医学部附属病院, 講師 (90334408)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 免疫 / 皮膚 / リンパ / 内皮細胞

Research Abstract

皮膚免疫におけるリンパ管の役割を、接触皮膚炎とケモカインの産生の二つの面から検討した。リンパ潅流に異常のあるマウスでは接触皮膚炎が増強しているが、主に惹起相に原因があり、リンパ管が炎症反応を鎮静化させる排水溝として重要であることが示唆された。またリンパ潅流に異常があっても、感作部位である皮膚において抗原提示が行われている証拠は得られず、樹状細胞の遊走もしくは抗原の所属リンパ節への流入が遅延していることが示唆された。リンパ管内皮細胞からのCCL21の発現制御に関しては、oncostatin MがErkのリン酸化を介してCCL21産生の増強を増強することが示された。Erkのリン酸化を阻害するMAPK inhibitorを抗原感作24時間前に注射したところ、接触皮膚炎が減弱したことから、接触皮膚炎の治療に有効である可能性が示された。

Research Products

• [Journal Article] IL-17F single nucleotide polymorphism is not associated with psoriasis vulgaris or atopic dermatitis in the Japanese population (2009)
  • Author(s): Shibata S, Saeki H, Tsunemi Y, Kato T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K
  • Journal Title: Journal of Dermatological Science 53 Pages: 5-163
  • NAID: 10025332564
  • Peer Reviewed
• [Journal Article] Interferon-18 gene polymorphism -137 G/C is associated with susceptibility to psoriasis vulgaris but not with atopic dermatitis in Japanese patients (2009)
  • Author(s): Kato T, Tsunemi Y, Saeki H, Shibata S, Sekiya T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, Tamaki K
  • Journal Title: Journal of Dermatological Science 53 Pages: 3-162
  • NAID: 10025332553
  • Peer Reviewed
• [Journal Article] Increased CCL1 levels in the sera and blister fluid of patients with bullous pemphigoid (2009)
  • Author(s): Miyagaki T, Sugaya M, Kagami S, Nakashima H, Ishiura N, Watanabe R, Ohmatsu H, Fujita H, Yazawa N, Kadono T, Fujimoto M, Saeki H, Tamaki K
  • Journal Title: Journal of Dermatological Science 54 Pages: 7-45
  • Peer Reviewed
• [Journal Article] IL-17F single nucleotide polymorphism is not associated with psoriasis vulgaris or atopic dermatitis in the Japanese population (2009)
  • Author(s): Shibata S, Saeki H, Tsunemi Y, Kato T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya Tamaki K
  • Journal Title: Journal of Dermatological Science 53 Pages: 163-51
  • NAID: 10025332564
  • Peer Reviewed
• [Journal Article] Interferon-18 gene polymorphism -137 G/C is associated with susceptibility to psoriasis vulgaris but not with atopic dermatitis in Japanese patients (2009)
  • Author(s): Kato T, Tsunemi Y, Saeki H, Shibata S, Sekiya T, Nakamura Kg, Kakinuma T, Kagami S, Fujita H, Tada y, Sugayat Tamaki K.
  • Journal Title: Journal of Dermatological Science 53 Pages: 162-3
  • NAID: 10025332553
  • Peer Reviewed
• [Journal Article] Increased CCL1 levels in the sera and blister fluid of patients with bullous pemphigoid (2009)
  • Author(s): Miyagaki T, Sugava M, Kagami S, Nakashima H, Ishiura N, Watanabe R, Ohmatsu H, Fujita H, Yazawa N, Kadono T, Fujimoto M, Saeki H, Tamaki K.
  • Journal Title: Journal of Dermatological Science 54 Pages: 45-7
  • Peer Reviewed
• [Journal Article] Serum chemokine levels in a case of angio-oedema associated with eosinophilia (2008)
  • Author(s): Yokobayashi H, Sugaya M, Miyagaki T, Kai H, inatani Y, Tamaki T
  • Journal Title: British Journal of Dermatology 159 Pages: 40-738
  • Peer Reviewed
• [Journal Article] Serum chemokine levels in a case of angio-oedema associated with eosinophilia. (2008)
  • Author(s): Yokobayashi H, Sugava M, Miyagaki T, Kai H, Minatani Y, Tamaki T
  • Journal Title: British Journal of Dermatology 159 Pages: 738-40
  • Peer Reviewed
• [Journal Article] CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders. (2007)
  • Author(s): Ohmatsu H, Sugaya M, Kadono T, Tamaki K.
  • Journal Title: Journal of Investigative Dermatology 127 Pages: 2466-8
  • Peer Reviewed
• [Journal Article] Does thrombosis cause intravascular fasciitis? (2007)
  • Author(s): Sugaya M, Tamaki K.
  • Journal Title: Acta Dermato-Venereologaica 87 Pages: 369-70
  • Peer Reviewed
• [Journal Article] FDG-PET in T-cell and NK-cell neoplasms. (2007)
  • Author(s): Kako S, Izutsu K, Ota Y, Minatani Y, Sugaya M, Momose T, Ohtomo K, Kanda Y, Chiba S, Motokura T, Kurokawa M.
  • Journal Title: Annals of Oncology 18 Pages: 1685-90
  • Peer Reviewed
• [Presentation] Impaired migration of dendritic cells and enhanced contact sensitivity responses in transgenic mice with lymphatic dysfunction (2008)
  • Author(s): Sugaya M, Kuwano Y, Miyagaki T, Ohmatsu H, Kakinuma T, Kadono T, Okochi H, Blauvelt A, Tamaki K
  • Organizer: 国際研究皮膚科学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 皮膚免疫反応におけるリンパ灌流の役割 (2007)
  • Author(s): 菅谷 誠
  • Organizer: 第106回 日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-04-21