Neural stem cell transplantation in a model of fetal alcohol effects

• Project/Area Number: 19790822
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: YOSHINAGA Toshihiro Sapporo Medical University, 医学部, 助教 (70404704)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 脳・神経 / 神経科学 / 再生医学 / 神経幹細胞 / アルコール / 脳神経 / 胎児性アルコール症候群

Research Abstract

胎児性アルコール症候群のモデルラットに対して,ラット胎仔由来の神経幹細胞の経静脈的移植療法を施行した。その結果,胎児性アルコール症候群の主要症状である多動性と衝動性の行動異常が正常ラットと同等の程度まで改善することを明らかにした。

Research Products

• [Journal Article] Lithium-induced suppression of transcription repressor NRSF/REST: effects on the dysfunction of neuronal differentiation by ethanol. (2008)
  • Author(s): Ishii T, Hashimoto E, Ukai W, Tateno M, YYoosshhiinnaaggaa TT, Saito S, Sohma H, Saito T.
  • Journal Title: European Journal of Pharmacology. 593 Pages: 36-43
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路障害のメカニズムとその修復法の探索神経細胞・神経幹細胞を用いたin vitro, in vivo解析 (2008)
  • Author(s): 鵜飼渉,石井貴男,吉永敏弘,館農勝,橋本恵理,小野貴文,渡邊公彦,渡邉一平,白坂智彦,齋藤利和
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 763-769
  • NAID: 10023976053
  • Peer Reviewed
• [Journal Article] アルコールによる脳障害とエピジェネティクス制御機構 (2008)
  • Author(s): 石井貴男,橋本恵理,鵜飼渉,館農勝,吉永敏弘,小野貴文,渡邊公彦,齋藤諭,齋藤利和
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 705-713
  • NAID: 10024436959
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路網の異常神経幹細胞を用いた修復の試み (2008)
  • Author(s): 鵜飼渉,橋本恵理,吉永敏弘,石井貴男,館農勝,小野貴文,渡邊公彦,齋藤諭,齋藤利和
  • Journal Title: 日本神経精神薬理学雑誌 28 Pages: 69-73
  • NAID: 10023965420
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路障害のメカニズムとその修復法の探索 : 神経細胞・神経幹細胞を用いたin vitro, in vivo解析 (2008)
  • Author(s): 鵜飼渉, 他
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 763-769
  • Peer Reviewed
• [Journal Article] アルコールによる脳障害とエピジェネティック制御機構 (2008)
  • Author(s): 石井貴男, 他
  • Journal Title: 日本アルコール・薬物医学会雑誌 43 Pages: 705-713
  • Peer Reviewed
• [Journal Article] Lithium-induced suppression of transcription repressor NRSF/REST : effects on the dysfunction of neuronal differentiation by ethanol (2008)
  • Author(s): Ishii T, et.al.
  • Journal Title: Eur J Pharmacol 593 Pages: 36-43
  • Peer Reviewed
• [Journal Article] アルコールによる脳神経回路網の異常 : 神経幹細胞を用いた修復の試み (2008)
  • Author(s): 鵜飼渉, 他
  • Journal Title: 日本神経精神薬理学雑誌 28 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Neural stem cell transplantation in a model of fetal alcohol effects. (2007)
  • Author(s): Yoshinaga T, Hashimoto E, Ukai W, Toki S, Saito S, Saito T.
  • Journal Title: Journal of Neural Transmission 72 Pages: 331-337
  • Peer Reviewed
• [Journal Article] Neural stem cell transplantion in a model of fetal alcohol effects (2007)
  • Author(s): Yoshinaga T.
  • Journal Title: Journal of Neural Transmission suppl(72) Pages: 331-337
  • Peer Reviewed
• [Journal Article] エタノールによる神経幹細胞の分化制御小胞体機能に関わる分子変動の解析 (2007)
  • Author(s): 石井 貴男
  • Journal Title: アルコールと医学生物学 27 Pages: 16-23
  • Peer Reviewed
• [Journal Article] 抗うつ薬の作用機序に関する新たな視点での考察 (2007)
  • Author(s): 今井 智之
  • Journal Title: 分子精神医学 7 Pages: 161-163
  • Peer Reviewed
• [Presentation] 胎児期アルコール曝露モデルに対する神経幹細胞移植の試み (2008)
  • Author(s): 吉永敏弘,石井貴男,館農勝,小野貴文,渡邊公彦,渡邉一平,白坂知彦,齋藤諭,橋本恵理,齋藤利和
  • Organizer: 第38回日本神経精神薬理学会
  • Year and Date: 2008-10-01
• [Presentation] 精神疾患に対する幹細胞移植療法の可能性に関する研究 (2008)
  • Author(s): 鵜飼渉,吉永敏弘,石井貴男,橋本恵理,小野貴文,館農勝,渡邊公彦,渡邉一平,白坂知彦,向裕加,齋藤諭,齋藤利和
  • Organizer: 第51回日本神経化学会
  • Year and Date: 2008-09-12
• [Presentation] 精神疾患に対する幹細胞移植療法の可能性に関する研究 (2008)
  • Author(s): 鵜飼渉, 他
  • Organizer: 第51回日本神経化学会
  • Place of Presentation: 富山
  • Year and Date: 2008-09-12
• [Presentation] New potential therapy of neural stem cell transplantation for repairing alcohol induced brain damage (2008)
  • Author(s): Saito T, Hashimoto E, Ukai W, Yoshinaga T, Ishii T, Tateno M, Saito S.
  • Organizer: 16th Collegium Internationale Neuro-Psychopharmacologicum
• [Presentation] The common aspects of pathophysiology of alcoholism and depression (2008)
  • Author(s): Tateno M, Ukai W, Yoshinaga T, Ishii T, Saito S, Hashimoto E, Saito T.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
• [Presentation] Translational research of repairing therapy for damaged brain (2008)
  • Author(s): Hashimoto E, Yoshinaga T, Ishii T, Saito S, Ukai W, Saito T
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
• [Presentation] The alteration of CREB/NRSF regulation in the neural stem cell dysfunction by ethanol (2008)
  • Author(s): Ukai W, Ishii T, Yoshinaga T, Tateno M, Ono T, Watanabe K, Hashimoto E, Saito S, Mukai Y, Saito T.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/14th Annual Meeting of the International Society for Biomedical Research on Alcoholism
• [Presentation] (Symposium) : Alcohol-induced brain damage : new findings from the Asian-Pacific region : The common aspects of pathophysiology of alcoholism and depression (2008)
  • Author(s): Ukai W, et.al.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/1 4th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Washington DC
• [Presentation] (Symposium) : Ethanol and brain function : relive, damage and repair : translational research of repairing therapy for damaged brain (2008)
  • Author(s): Hashimoto E, et.al.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Aloaholism/1 4th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Washington DC
• [Presentation] The alteration of CREB/NRSF regulation in the neural stem cell dysfunction by ethanol (2008)
  • Author(s): Ukai W, et.al.
  • Organizer: Joint Congress of 31th Annual Scientific Meeting of the Research Society on Alcoholism/1 4th Annual Meeting of the International Society for Biomedical Research on Alcoholism
  • Place of Presentation: Washington DC
• [Presentation] (Symposium) : Translational research in addiction : Merging neurobiology with clinical treatment: new potential therapy of neural stem cell transplantation for repairing alcohol-induced brain damage (2008)
  • Author(s): Saito T, et.al.
  • Organizer: 16th Collegium International Neuro-Psychiopharm acologium
  • Place of Presentation: Munich
• [Presentation] The effect of lithium on ethanol inhibition of neuronal differentiation : role for transcription repressor NRSF (2007)
  • Author(s): Ishii T , Ukai W, Tateno M, Yoshinaga T, Ono T, Saito S, Hashimoto E, Saito T.
  • Organizer: The 37th Annual Meeting of Society for Neuroscience
• [Presentation] The role of endoplasmic reticulum in the ethanol-induced neural stem cell dysrunction (2007)
  • Author(s): Ishii T.
  • Organizer: The 37th Annual Meeting of Society for Neuroscience
  • Place of Presentation: San Diego,USA
• [Patent(Industrial Property Rights)] Pharmaceutical compounds containing atelocollagen and stem cells for treatment of psychiatric or neurological diseases (2007)
  • Inventor(s): 吉永敏弘
  • Industrial Property Rights Holder: 吉永敏弘
  • Acquisition Date: 2007
  • Overseas
• [Patent(Industrial Property Rights)] Pharmaceutical compounds containing atelocollagen and stem cells for treatment of psychiatric or neurological diseases (2007)
  • Inventor(s): 吉永敏弘,他
  • Industrial Property Rights Holder: 吉永敏弘,他
  • Acquisition Date: 2007
  • Overseas