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Effects of drug acting on mitochondrial calcium uptake in model mice for bipolar disorder

Research Project

Project/Area Number 19790844
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KUBOTA Mie  The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, 研究員 (90344035)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsミトコンドリア / 双極性障害 / 精神薬理学 / mitochondria / polymerase γ / cyclophilin D / cycrosporin A / permeability transition pore / polymeraseγ / calcium signaling
Research Abstract

双極性障害モデル動物である脳内mtDNA変異蓄積マウスを用い、ミトコンドリアのCa2+制御異常を調べたところ、変異マウス脳ミトコンドリアでは、Ca2+取り込み速度亢進が観察された。この分子機構と変異マウスで観察された異常行動との関連について調べるため、CypD阻害剤の輪回し行動に対する影響を検討した。CypD阻害剤を変異マウスに約2週間、連続的に腹腔内投与し、輪回し行動を観察したところ、約1週間後から行動異常は徐々に減少し、2週間後には有意に減少した。ミトコンドリア機能を標的とした薬剤が、新たな奏効機序を持つ気分安定薬候補物質になる可能性が考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2008 2007

All Presentation (7 results)

  • [Presentation] Effects of drug acting on mitochondrial calcium uptak in mutant POLG transgenic mice2008

    • Author(s)
      Mie Kubota
    • Organizer
      2nd World Federation of Societies of Biological Psychiatry Asia-Paific Congress and 30th Annual Meeting of Japan Societies Biological Psychiatry
    • Place of Presentation
      Toyama
    • Year and Date
      2008-09-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of drug acting on mitochondrial calcium uptake in mutant POLG transgenic mice2008

    • Author(s)
      窪田美恵
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      ANAクラウンプラザホテル富山
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal mitochondrial Ca^<2+> dynamics and behavioral phenotypes in transgenic mice with mitochondrial DNA defects2008

    • Author(s)
      Mie Kubota
    • Organizer
      The 7th European Meeting on Mitochondrial Pathology
    • Place of Presentation
      the City Conference Centre Stockholm
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Abnormal mitochondrial Ca2+ dynamics and behavioral phenotypes in transgenic mice with mitochondrial DNA defects2008

    • Author(s)
      Mie Kubota
    • Organizer
      The 7th EuropeanMeeting on Mitochondria Pathology
    • Place of Presentation
      Stockholm
    • Year and Date
      2008-06-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene Expression Profile in the Brain of Animal Model for Bipolar Disorder2007

    • Author(s)
      Mie Kubota
    • Organizer
      Cold Spring Harbor Laboratory Meeting Integrative Approaches to Brain Complexity
    • Place of Presentation
      Cambridge
    • Year and Date
      2007-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] GENE EXPRESSION PROFILE IN THE BRAIN OF ANIMAL MODELFOR BIPOLAR DISOEDER2007

    • Author(s)
      Mie Kubota
    • Organizer
      Cold Spring Harbor Meeting (Integrative Approaches To Brain Complexity)
    • Place of Presentation
      The Welcome Trust Conference Center
    • Year and Date
      2007-09-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 双極性障害モデル動物における単離ミトコンドリアを用いたカルシウム取り込み脳の薬理学的検討2007

    • Author(s)
      窪田 美恵
    • Organizer
      日本生物精神医学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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