Expression analysis of N-Myc downstream regulated gene 2 (Ndrg2) using the embryonic spinal cord and the adult brain
Project/Area Number |
19790849
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
TAKAHASHI Kou National Center of Neurology and Psychiatry, 老人精神保健部, 外来研究員 (20415582)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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Keywords | 精神薬理 / 抗うつ薬 / アストロサイト / 神経幹細胞 / 発生 / 分化 / 電気けいれん / microarray / real time PCR法 / western blot法 / real time PCR 法 / western blot 法 |
Research Abstract |
We have reported that the expression of Ndrg2 was decreased after chronic antidepressant treatment and electroconvulsive treatment in rat frontal cortex. However, roles of Ndrg2 in the central nervous system were poorly understood. In the present study, we demonstrated that the expression of Ndrg2 was detected in neuronal stem cells and astrocyte in both the embryonic spinal cord and the adult brain. These results may indicate that Ndrg2 involved in the mechanisms of proliferation and differentiation in neuronal stem cells.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010
Author(s)
Yamada, M., Takahashi, K., Ukai, W., Hashimoto, E., Saito, T., Yamada M.
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Journal Title
Neuroreport 21(2)
Pages: 138-142
Related Report
Peer Reviewed
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[Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010
Author(s)
Yamada, M., Takahashi, K., Ukai, W, Hashimoto, E., Saito, T., Yamada M.
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Journal Title
Neuroreport 21
Pages: 138-142
Related Report
Peer Reviewed
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[Journal Article] Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.2008
Author(s)
Takahashi, K., Saitoh, A., Yamada, M., Maruyama, Y., Hirose, N., Kamei, J., Yamada, M.
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Journal Title
J Pharmacol. Sci. 108(3)
Pages: 320-334
NAID
Related Report
Peer Reviewed
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[Journal Article] Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S, 5R)-2, 5-di methyl-4-(2-propenyl)-1-pi perazinyl]-(3-methoxyphenyl)methyl]-N, N -diethylbenzamide] in an olfactory bulbectomized rat model.2008
Author(s)
Saitoh, A., Yamada, M., Yamada, M., Takahashi K., Yamaguchi, K., Murasawa, H., Nakatani, A., Tatsumi, Y., Hirose, N., Kamei, J.
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Journal Title
Brain research 1208
Pages: 160-169
Related Report
Peer Reviewed
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[Presentation] A glutamate release inhibitor rapidly attenuates hyperemotional responses in OBX rats.2009
Author(s)
Inagaki, M., Takahashi, K., Saitoh, A., Yamada, M., Iwai, T., Nakaani, A., Murasawa, H., Yoshida, M., Yamaguchi, K., Yamada, M.
Organizer
The 1st Meeting of the Asian College of Neuropsychopharmacology
Place of Presentation
国立京都国際会館(京都府)
Year and Date
2009-11-13
Related Report
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[Presentation] A glutamate release inhibitor rapidly attenuates hyperemotional responses in OBX rats.2009
Author(s)
Inagaki, M., Takahashi, K., Saitoh, A., Yamada, M., Iwai, T., Nakaani, A., Murasawa, H., Yoshida, M., Yamaguchi, K., Yamada, M.
Organizer
The 1st Meeting of the Asian College of Neuropsychopharmacology
Place of Presentation
Kyoto International Conference Center
Related Report
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[Presentation] Chronic treatment with a selective opioid-delta agonist SNC80 affects the expression of excitatory amino-acid transporter genes in frontal cortex of olfactory bulbectomized rat.2009
Author(s)
Saitoh, A., Yamada, M., Takahashi, K., Iwai, T., Inagaki, M., Yamada, M.
Organizer
The 1st Meeting of the Asian College of Neuropsychopharmacology
Place of Presentation
Kyoto International Conference Center
Related Report
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