An investigation of Tc-99m MIBI washout rate and kinetics in myocardium.
| Project/Area Number |
19790850
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
OKIZAKI Atsutaka Asahikawa Medical College, 医学部, 講師 (10322893)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,230,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | コンパートメントモデル解析 / Tc-99m MIBI / 心筋血流 / 洗い出し率 / 薬物動態 / Tc-99mMIBI / dynamic SPECT |
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| Research Abstract |
We performed a mathematical compartment model analysis with Tc-99m MIBI. A 2-compartment model was better than other model in our study. There were significant correlations between the rate constants and heart to mediastinum ratio. Therefore, the pharmacokinetics of Tc-99m MIBI might show the condition of myocardium. Moreover, the influx rate constant in patients with ischemic heart disease was reduced than it in normal control. This method might be useful to evaluate the condition of myocardial abnormality.
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Report
(4 results)
Research Products
(15 results)
