Development of auto detect and analysis system for PET imaging on acute cerebrovascular diseases

• Project/Area Number: 19790861
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: KOBAYASHI Masato University of Fukui, 保健学系, 助教 (30444235)
• Research Collaborator: OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813) ; KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 准教授 (50305603) ; MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 核医学(PET) / 画像解析 / 画像診断技術 / 画像診断コンピュータ支援技術 / 脳・神経 / 放射線 / 画像診断技術学 / 画像解析学

Research Abstract

The purpose of this study is to develop auto detect and analysis system combining our noninvasive 15O-PET examination method using computer-aided diagnosis technology for patients with cerebrovascular disease. Auto analysis system was developed by location of regions of interest and calculation of left-to-right ratio using Matlab and Image J software in animal and clinical study. We also added auto detection system of fissure of Sylvius and stroke areas as auto analysis system using Image J.

Research Products

• [Journal Article] 18F-FDGを用いた脳PET検査の健常者データベースにおけるTransmission撮像および減弱補正法の影響 (2010)
  • Author(s): 小林正和, (他9名)
  • Journal Title: 日本放射線技術学会雑誌 20 Pages: 42-48
  • NAID: 10025978080
  • Peer Reviewed
• [Journal Article] ^<18>F-FDGを用いた脳PET検査の健常者データベースにおけるTransmission撮像および減弱補正法の影響 (2010)
  • Author(s): 小林正和, 杉本勝也, 丸山力哉, 工藤崇, 辻川哲也, 清野泰, 小野口昌久, 川井恵一, 藤林靖久, 岡沢秀彦
  • Journal Title: 日本放射線技術学会雑誌 66 Pages: 42-48
  • NAID: 10025978080
  • Peer Reviewed
• [Journal Article] Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow: a PET study with 15O-water (2009)
  • Author(s): Hussain, R., Tsuchida, T., Kudo, T,., Kobayashi, M., (他4名)
  • Journal Title: Annals of Nuclear Medicine 23 Pages: 717-723
  • NAID: 10026099251
  • Peer Reviewed
• [Journal Article] Validation of the calculation of the clearance rate constant (kmono) of [11C]acetate using parametric kmono image for myocardial oxidative metabolism (2009)
  • Author(s): Hussain, R., Kudo, T., Tsujikawa, T., Kobayashi, M., (他2名)
  • Journal Title: Nuclear Medicine and Biology 36 Pages: 877-882
  • Peer Reviewed
• [Journal Article] Shorter examination method for the diagnosis of misery perfusion using count-based OEF elevation in 15O-gas PET (2008)
  • Author(s): Kobayashi, M., (他6名)
  • Journal Title: Journal of Nuclear Medicine 49 Pages: 242-246
  • Peer Reviewed
• [Journal Article] Shorter examination method for the diagnosis of misery perfusion using count-based OEF elevation in ^<15>O-Gas PET (2008)
  • Author(s): Kobayashi M, Kudo T, Tsujikawa T, Isozaki M, Arai Y, Fujibayashi Y, Okazawa H
  • Journal Title: The Journal of Nuclear Medicine 49 Pages: 242-246
  • Peer Reviewed
• [Journal Article] Shorter Examination Method for the Diagnosis of Misery Perfusion with Count-based Oxygen Extraction Fraction Elevation in 15O-Gas PET (2008)
  • Author(s): Masato Kobayashi, Takashi Kudo, Tetsuya Tsujikawa, Makoto Isozaki, Yoshikazu Arai, Yasuhisa Fujibayashi, Hidehiko Okazawa
  • Journal Title: The Journal of Nuclear Medicine 49 Pages: 242-246
  • Peer Reviewed
• [Journal Article] Clinical implication and prognosis of normal baseline cerebral blood flow with impaired vascular reserve in patients with major cerebral artery occlusive disease
  • Author(s): Isozaki, M., Arai, Y., Kudo, T., Kiyono, Y., Kobayashi, M., (他3名)
  • Journal Title: Annals of Nuclear Medicine (in press)
  • NAID: 10027658838
  • Peer Reviewed
• [Presentation] Measurement of cerebral oxygen metabolism and oxygen metabolism of rats using injectable O-15 oxygen and steady-state method combining bolus and increscent injection (2010)
  • Author(s): Kobayashi, M.
  • Organizer: International Conference on Brain Function and Development
  • Place of Presentation: Fujita Hotel, (Fukui)
• [Presentation] 定常投与法による[15O]標識人工赤血球の脳循環代謝測定 (2009)
  • Author(s): 小林正和
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2009-10-02
• [Presentation] 定常投与法による[^<15>O]標識人工赤血球の脳循環代謝測定 (2009)
  • Author(s): 小林正和, 清野泰, 工藤崇, 辻川哲也, 脇厚生, 吉井幸恵, 西井龍一, 小野口昌久, 川井恵一, 藤林靖久, 岡沢秀彦
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川グランドホテル(北海道)
  • Year and Date: 2009-10-02
• [Presentation] 簡便なPET定量検査を目指した薬剤持続投与システムの確立 (2009)
  • Author(s): 小林正和, 杉本勝也, 丸山力哉, 川井恵一, 藤林靖久, 岡沢秀彦
  • Organizer: 日本放射線技術学会第64回総会学術大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-04-18
• [Presentation] 簡便なPET定量検査を目指した薬剤持続投与システムの確立 (2009)
  • Author(s): 小林正和
  • Organizer: 日本放射線技術学会第64回総会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-04-05
• [Presentation] Development of steadystate method combining bolus and increscent injection with a multiprogramming syringe pump (2009)
  • Author(s): Kobayashi, M.
  • Organizer: The 24rd International Symposium on Cerebral Blood Flow and Metabolism & the 9th International Conference on Quantification of Brain Function with PET (Brain 09&Brain PET 09)
  • Place of Presentation: Conference venue (USA)
• [Presentation] Measurement of cerebral oxygen metabolism of rats using injectable O-15 oxygen and steady-state method (2009)
  • Author(s): Kobayashi, M.
  • Organizer: The 56th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Metro Toronto Convention Centre (Canada)
• [Presentation] [O-15]酸素ガス標識人工赤血球の定常投与法を用いた正常ラットの脳循環代謝測定 (2009)
  • Author(s): 小林正和
  • Organizer: 日本分子イメージング学会第4回総会・学術集会
  • Place of Presentation: 学術総合センター(東京都)
• [Presentation] Measurement of cerebral oxygen metabolism of rats using injectable O-15 oxygen and steady-state method (2009)
  • Author(s): Kobayashi M, Tiwari VN, Maruyama R, Kiyono Y, Kudo T, Tsujikawa T, Yoshii Y, Fujibayashi Y Okazawa H
  • Organizer: The 56th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: Metro Toronto Convention Center (Canada)
• [Presentation] Development of steady-state method combining bolus and increscent injection with a multi-programming syringe pump (2009)
  • Author(s): Kobayashi M, Maruyama R, Higaki Y, Kiyono Y, Kudo T, Tsujikawa T, Kawai K, Fujibayashi Y, Okazawa H
  • Organizer: The 24rd International Symposium on Cerebral Blood Flow and Metabolism & the 9th International Conference on Ouantification of Brain Function with PET
  • Place of Presentation: McCormick Place, Chicago (USA)
• [Presentation] 新規小動物PET装置における15O標識水を用いた脳循環代謝測定の検討 (2008)
  • Author(s): 小林正和
  • Organizer: 第48回日本核医学会学術総会
  • Place of Presentation: 幕張メッセ(千葉県)
• [Presentation] 新規小動物PET装置を利用した正常ラットの脳血流量測定 (2008)
  • Author(s): 小林正和
  • Organizer: 日本分子イメージング学会第3回総会・学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] Emission segmented attenuation correction method without transmission scan can accurately measure tissue tracer concentration (2008)
  • Author(s): Kobayashi M, Kudo T, Kiyono Y, Tsujikawa T, Watanabe M, Okazawa H, Fujibayashi Y
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans (USA)
• [Presentation] 無採血脳PET検査法を用いた貧困灌流領域診断における短時間撮像法の検討 (2007)
  • Author(s): 小林正和
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター(宮城県)
• [Presentation] 無採血脳PET検査法を用いた貧困灌流領域診断における短時間撮像法の検討 (2007)
  • Author(s): 小林正和、岡沢秀彦、辻川哲也、工藤崇、藤林靖久
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台国際センター
• [Patent(Industrial Property Rights)] PET薬剤送出装置およびその作動方法 (2008)
  • Inventor(s): 小林正和, 岡沢秀彦
  • Industrial Property Rights Holder: 福井大学
  • Filing Date: 2008-07-11
• [Patent(Industrial Property Rights)] PET薬剤送出装置およびその作動方法 (2008)
  • Inventor(s): 小林正和、岡沢英彦
  • Industrial Property Rights Holder: 国立大学法人福井大学
  • Filing Date: 2008-07-11