Study on molecular imaging for tumor-specific acetate metabolism

• Project/Area Number: 19790864
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: YOSHII Yukie University of Fukui, 高エネルギー医学研究センター, 助教 (10397242)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,350,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: 画像診断学(含放射線診断学、核医学) / 腫瘍酢酸イメージング / がん / 代謝 / 低酸素 / イメージング / 酢酸

Research Abstract

本研究では、がん診断を目的とした新規「分子イメージング」法の開発を目指し、その基盤となるがん特異的代謝に関する研究を行った。その結果、(1) がん細胞は細胞質性Acetyl-CoA synthetase (ACSS2)によって触媒される特異的酢酸産生反応を有すること、(2) ACSS2による代謝は低酸素環境下で亢進すること、(3) ACSS2代謝活性を放射性酢酸トレーサーでモニターできることを明らかにした。こうした発見は、がん特異的代謝を標的としたがん診断法を開発する上で有用な情報を提供すると考えられる。

Research Products

• [Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia : the possible function in tumor acetyl-CoA/acetate metabolism (2009)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, Yasushi Kiyono, Atsuo Waki, Masato Kobayashi, Tetsuya Tsujikawa, Takashi Kudo, Hidehiko Okazawa, Yoshiharu Yonekura, Yasuhisa Fujibayashi
  • Journal Title: Cancer Science (2009) (in press)
  • NAID: 10025145355
  • Peer Reviewed
• [Journal Article] Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, Yasushi Kiyono, Atsuo Waki, Masato Kobayashi, Tetsuya Tsujikawa, Takashi Kudo, Hidehiko Okazawa, Yoshiharu Yonekura, Yasuhisa Fujibayashi
  • Journal Title: Cancer Science (2009) (in press)
  • NAID: 10025145355
  • Peer Reviewed
• [Presentation] Tumor acetate imaging : a new paradigm for understanding tumor-specific hypoxic metabolism.(Oral presentation) (2008)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, Masato Kobayashi, Yasushi Kiyono, and Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Tumor acetate imaging : a new paradigm for understanding tumor-specific hypoxic metabolism (2008)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, Masato Kobayashi, Yasushi Kiyono, and Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting
  • Place of Presentation: New Orleans, Louisiana, USA
• [Presentation] Is acetate a metabolic imaging marker of tumors under hypoxia?(Poster presentation) (2007)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, and Yasuhisa Fujibayashi
  • Organizer: The Academy of Molecular Imaging and the Society for Molecular Imaging (AMI/SMI) Molecular Imaging Joint Conference
  • Place of Presentation: Providence, Rhode island, USA
• [Presentation] Acceleration of tumor acetate uptake under hypoxia : a new perception of tumor imaging by acetate.(Oral presentation) (2007)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, and Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] Tumor-specific fermentative pathway for energy production : a possible target for tumor imaging.(Poster presentation) (2007)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, Tetsuya Mori, and Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting
  • Place of Presentation: Washington DC, USA
• [Presentation] 悪性腫瘍を標的とした酢酸代謝イメージングの新展開.(口頭発表) (2007)
  • Author(s): 吉井幸恵, 古川高子, 吉井裕, 藤林康久
  • Organizer: 第47回日本核医学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 癌特異な酢酸産生発酵過程-癌分子イメージング研究から生まれた新知見.(口頭発表) (2007)
  • Author(s): 吉井幸恵, 古川高子, 吉井裕, 森哲也, 藤林康久
  • Organizer: 第2回日本分子イメージング学会
  • Place of Presentation: 福井
• [Presentation] Acceleration of tumor acetate uptake under hypoxia: a new perception of tumor imaging by acetate (2007)
  • Author(s): Yukie Yoshii, Takako Furukawa, Hiroshi Yoshii, and Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting 2007
  • Place of Presentation: Washington DC, USA
• [Remarks] 【産学連携・講演】吉井幸恵. がん特異的酢酸代謝を標的としたがんバイオマーカー・診断法・治療法. 福井大学・科学技術振興機構(JST)主催 新技術説明会. 2008.8.22(東京)
• [Remarks] 【記事掲載】日経バイオテクノロジージャパンに記事掲載「福井大ががん特異的な酢酸代謝経路を発見、新規バイオマーカーの可能性」2008.8.26
• [Remarks]
  • URL: http://www1.fukui-med.ac.jp/birc/index.html
• [Patent(Industrial Property Rights)] がん特異的酢酸代謝を標的としたがんバイオマーカー・検査方法・治療剤 (2008)
  • Inventor(s): 吉井幸恵, 藤林康久, 古川高子, 清野泰, 森哲也, 吉井裕
  • Industrial Property Rights Holder: 福井大学
  • Industrial Property Number: 2008-120023
  • Filing Date: 2008-05-01