| Budget Amount *help |
¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Research Abstract |
In this study, to demonstrate the excess of oxidative stress in chronic heart failure patients, We also examine the effect of Beta blockers and statins, on cardiac metabolism by the C11-acetate positron emission tomography(PET). Enrolled in this study were 21 patients with chronic heart failure. All patients underwent β-blockers treatment and C11-acetate PET. The oxygen consumption was measured by the monoexponential clearance rate of 11C-acetate (Kmono) for before and after treatment. Cardiac efficiency (CE) was determined using the concept of work metabolic index (WMI). WMI was calculated as WMI=(stroke volume index) ×(systolic blood pressure)× (heart rate)/Kmono. The patients were divided into two groups: improved EF and deteriorated EF by treatment. No significant differences were observed in characteristics at baseline. The ratio of ischemic cardiomyopathy and the frequency of statins or β-blockers,did not change. Serum levels of IL-6, TNF-a and sVCAM-1 were increased in the deteriorated group. Furthermore, no significant changes were in this study.
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