Basic experiment and reseach of clinical study that uses bisphosphonate with radiation therapy

• Project/Area Number: 19790905
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: ETO Hidehiro Kurume University, 医学部, 助教 (50309796)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,220,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 癌 / 細胞.組織 / 放射線 / 放射線治療 / 乳癌細胞 / ビスフォスフォネート製剤 / ヒト乳癌細胞 / bisnhosnhonate / bisphosphonate

Research Abstract

The utility was cultured human breast cancer cell (MDA, MCF-7), used the medicine made of bisphosphonate and radiation with a clinical machine examined basic and clinical. It was suggested to contribute to a decrease of the cancer cell in a basic experiment by simultaneous using the medicine made of bisphosphonate and irradiation. In clinically, The pain, the bone density, and the attenuation values of CT were compared without using together and using together the medicine made of bisphosphonate for the patient of the thighbone metastasis. The utility of using together was considered from the basic experiment result though there was no significant difference because it was small number of cases.