Improving accuracy of Iodine-125 permanent implant brachytherapy for prostate cancer based on real time in vivo dosimetry

• Project/Area Number: 19790909
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Osaka University (2008-2009); Japanese Foundation For Cancer Research (2007)
• Principal Investigator: TAKAHASHI Yutaka Osaka University, 大学院・医学系研究科, 特任助教(常勤) (40353461)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥2,230,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: I125永久挿入治療 / 前立腺 / 生体内線量測定 / 高精度化 / 体内線量測定 / 前立腺癌 / I-125永久挿入治療 / リアルタイム体内線量測定 / MOSFET

Research Abstract

Iodine-125 permanent implant brachytherapy has been widely practiced treatment for localized prostate cancer. The purpose of this study is to establish the real time in vivo dosimetry system in this therapy using MOSFET 5-linear array. We evaluated the various physical characteristics and the overall dosimetric accuracy which reproduced clinical setting in the original phantom study. The result of phantom study showed that in vivo dosimetry in permanent implant brachytherapy can be performed within 15%. These results suggest further improvement of dosimetric accuracy.

Research Products

• [Journal Article] Verification of air-kerma strength 125I seed for permanent prostate implants in Japan. (2009)
  • Author(s): Sumida I, Koizumi M, Takahashi Y, Inoue T, et al.
  • Journal Title: Int. J. Clin. Oncol. 14(6) Pages: 525-528
  • NAID: 10027201323
  • Peer Reviewed
• [Journal Article] Verification of air-kerma strength 1251 seed for permanent prostate implants in Japan (2009)
  • Author(s): Sumida I, Koizumi M, Takahashi Y, Inoue T, et al.
  • Journal Title: International Journal of Clinical Oncology 14(6) Pages: 525-528
  • Peer Reviewed
• [Journal Article] Feasibility study of real time in vivo dosimetry with MOSFET linear array in I-125 prostate permanent implant brachytherapy. (2007)
  • Author(s): Yutaka Takahashi, Hidenobu Tachibana, Akira Ito, Takuyo Kozuka, Yuki Otani, Takashi Yamashita
  • Journal Title: Jpn J Med Phys 27(suppl.4) Pages: 119-120
  • Peer Reviewed
• [Journal Article] Feasibility study of real time in vivo dosimetry with MOSFET linear array in I-125 prostate permanent implant brachytherapy (2007)
  • Author(s): Yutaka Takahashi, Hidenobu Tachibana, Akira Ito, Takuyo Kozuka, Yuki Otani, Takashi Yamashita.
  • Journal Title: Jpn J. Med. Phys 27(suppl.4) Pages: 119-120
• [Presentation] Uncertainty of Real Time in Vivo Dosimetry with MOSFET Linear Array in I-125 Prostate Permanent Implant Brachytherapy. (2008)
  • Author(s): Yutaka Takahashi, Hidenobu Tachibana, Iori Sumida1, Takuyo Kozuka, Akira Ito, Takashi Yamashita
  • Organizer: AAPM annual meeting
  • Place of Presentation: Houston
  • Year and Date: 2008-07-27
• [Presentation] Uncertainty of Real Time in Vivo Dosimetry with MOSFET Linear Array in I-125 Prostate Permanent Implant Brachytherapy (2008)
  • Author(s): Yutaka Takahashi, et.al.
  • Organizer: American Association of Physicist in Medicine. 50th Annual Meeting
  • Place of Presentation: Houston
  • Year and Date: 2008-07-27
• [Presentation] I-125永久挿入治療のリアルタイム体内線量測定によるQAシステムの開発. (2007)
  • Author(s): 高橋豊、橘英伸、小塚拓洋、隅田伊織、熊田まどか、高橋民雄、倉本秋夫、伊藤彬、山下孝
  • Organizer: 第19回日本放射線腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-15
• [Presentation] I-125永久挿入治療のリアルタイム体内線量測定によるQAシステムの開発 (2007)
  • Author(s): 高橋 豊
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-15
• [Presentation] Feasibility study of real time in vivo dosimetry with MOSFET linear array in I-125 prostate permanent implant brachytherapy. (2007)
  • Author(s): Yutaka Takahashi, Hidenobu Tachibana, Akira Ito, Takuyo Kozuka, Yuki Otani, Takashi Yamashita
  • Organizer: 第93回日本医学物理学会
  • Place of Presentation: 新潟
  • Year and Date: 2007-09-29
• [Presentation] Feasibility study of real time in vivo dosimetry with MOSFET linear array in I-125 prostate permanent implant brachytherapy (2007)
  • Author(s): 高橋 豊
  • Organizer: 日本医学物理学会
  • Place of Presentation: 新潟
  • Year and Date: 2007-09-29
• [Presentation] Quality Assurance in I-125 Permanent Implant Brachytherapy (2007)
  • Author(s): Yutaka Takahashi
  • Organizer: University of Minnesota Medical Physics Meeting
  • Place of Presentation: University of Minnesota
  • Year and Date: 2007-07-21
• [Presentation] Development of quality assurance system in prostate permanent implant brachytherapy. (2007)
  • Author(s): Yutaka Takahashi
  • Organizer: University of Minnesota Physics Meeting
  • Place of Presentation: Minneapolis
  • Year and Date: 2007-07-20