Increased radiosensitivity through autophagy

• Project/Area Number: 19790910
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: ENDO Hiroko Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 大阪府立成人病センター(研究所)・研究所, 研究員 (20359300)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,170,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
• Keywords: 小胞体ストレス / オートファジー / 放射線治療

Research Abstract

固形腫瘍内に存在する低酸素領域は、癌の放射線抵抗性の一因である。我々は、低酸素下ではinsulin-like growth factor(IGF)刺激によって癌細胞の放射線感受性が増大することを見出した。本研究では、IGFによる放射線感受性増大のメカニズムを詳細に検討した。膵臓がん細胞AsPC-1ではIGF刺激によって誘導された小胞体ストレスおよびオートファジーによって放射線感受性が増大することが明らかとなったが、小胞体ストレスとオートファジーの直接的な関連は見出せなかった。

Research Products

• [Journal Article] Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through ER stress under hypoxic conditions. (2008)
  • Author(s): Isohasi F, Endo H, Mukai M, Inoue T, Inoue M
  • Journal Title: Cancer Sci 99 Pages: 2395-2401
  • Peer Reviewed
• [Journal Article] IGFBPs contribute to survival of pancreatic cancer cells under hypoxic conditions. (2008)
  • Author(s): Koga T, Endo H, Miyamoto Y, Mukai M, Akira S, Inoue M
  • Journal Title: Cancer Lett 268 Pages: 82-88
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through ER stress under hypoxic conditions (2008)
  • Author(s): Isohashi, F., Endo, H., Mukai, M., et al.
  • Journal Title: Cancer Sci 99 Pages: 2395-401
  • Peer Reviewed
• [Journal Article] IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions (2008)
  • Author(s): Koga, T., Endo, H., Miyamoto, Y., et al.
  • Journal Title: Cancer Lett 268 Pages: 82-88
  • Peer Reviewed
• [Journal Article] Activation of insulin-like growth factor signaling induces apoptotic cell death under prolonged hypoxia by enhancing endoplasmic reticulum stress response. (2007)
  • Author(s): Endo H, Murata K, Mukai M, Ishikawa O, Inoue M
  • Journal Title: Cancer Res 67 Pages: 8095-8103
  • Peer Reviewed
• [Journal Article] Activation of insulin-like growth factor signaling inducesapoptotic cell death under prolonged hypoxia by enhancing endoplasmic reticulum stress response (2007)
  • Author(s): Endo, H., Murata, K., Mukai, M., et. al.
  • Journal Title: Cancer Res 67 Pages: 8095-103
  • Peer Reviewed
• [Journal Article] Regulation of hypoxia-inducible factor 1 by glucose availability under hvpoxic conditions. (2007)
  • Author(s): Zhou, J., Hara, K., InoueM., et. al.
  • Journal Title: Kobe J Med Sci 53 Pages: 283-296
  • Peer Reviewed
• [Presentation] Activation of IGF signaling under hypoxic conditions increases radiosensitivity in AsPC-1 cells through ER stress (2007)
  • Author(s): 遠藤洋子
  • Organizer: 日本癌学会
  • Place of Presentation: 国内
  • Year and Date: 2007-10-04
• [Presentation] Activation of IGF signaling under hypoxic conditions increases radiosensitivity in AsPC-1 cells through ER stress (2007)
  • Author(s): 遠藤 洋子
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04