Establishment of new spiculation beam radiation therapy using Circadianrhythm.

• Project/Area Number: 19790924
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: IWADATE Manabu Fukushima Medical University, 医学部, 助教 (00381393)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: サーカディアン / 癌 / 時計遺伝子 / サーカディアンリズム / 加速器分析質量器 / 14C / 放射性同位物質

Research Abstract

We performed a study to aim at the realization of the personalized medicine by we individualized the drug choice that there was not of the burden, and giving the cytoreductive effect with the anticancer drug medication to give before radiotherapy to the patients to establish new cancer radiotherapy using circadian rhythm.
We analyzed the circadian rhythm in the first year and underwent test for drug sensitivity using circadian rhythm using a cancer cell in the second year and demonstrated that the effect of the anticancer drug changed by circadian rhythm.
Was based on circadian rhythm by enforcement of the anticancer drug sensitivity testing in the mouse which made make a cancer bearing as vivisection when put it in the last year; test it; examined it.