Analysis of malignant mechanism of gastrointestinal stromal tumors

• Project/Area Number: 19790939
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SETOGUCHI Tomohiko Hamamatsu University School of Medicine, 医学部, リサーチアシスタント (80436956)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 消化管間質腫瘍(GIST) / 肝転移 / loss of heterozygosity / GIST / Loss of heterozygosity (LOH) / Liver metastasis

Research Abstract

4GIST臨床検体を用いて,マイクロアレイ解析で網羅的遺伝子解析を施行.さらにRealtime-PCR解析を用いることで,GIST悪性化機序に関わると予測される遺伝子候補を見出した.良性GISTと悪性GISTの間で現在蛋白レベルでも発現に違いがあるのか免疫組織染色で解析中である.

Research Products

• [Journal Article] Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. (2007)
  • Author(s): Hirotoshi Kikuchi
  • Journal Title: Cancer Science 98 (11) Pages: 1734-39
• [Journal Article] Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors (2007)
  • Author(s): 菊池 寛利
  • Journal Title: Cancer Science 98 Pages: 1734-1734
• [Presentation] GIST肝転移に対する根治的肝切除後のImatinib適応症例についての解析 (2008)
  • Author(s): 山本真義
  • Organizer: 日本癌治療学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-30
• [Presentation] GIST肝転移巣におけるc-kit遺伝子領域のLOHの有無と肝切除後の予後についての検討 (2008)
  • Author(s): 山本 真義
  • Organizer: 胃癌学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2008-02-29
• [Presentation] Effect of loss of heterozygosity of the c-kit gene on Liver metastasis from gastrointestinal stromal tumors. (2008)
  • Author(s): Tomohiko Setoguchi
  • Organizer: American association for cancer research
  • Place of Presentation: Sandiego
• [Presentation] Effect of loss of heterozygosity of the c-kit gene on Liver metastasis from gastrointestinal stromal tumors (2008)
  • Author(s): Tomohiko setoguchi
  • Organizer: American association for cancer research
  • Place of Presentation: Sandiego