Analysis of malignant mechanism of gastrointestinal stromal tumors
Project/Area Number |
19790939
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
SETOGUCHI Tomohiko Hamamatsu University School of Medicine, 医学部, リサーチアシスタント (80436956)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
Keywords | 消化管間質腫瘍(GIST) / 肝転移 / loss of heterozygosity / GIST / Loss of heterozygosity (LOH) / Liver metastasis |
Research Abstract |
4GIST臨床検体を用いて,マイクロアレイ解析で網羅的遺伝子解析を施行.さらにRealtime-PCR解析を用いることで,GIST悪性化機序に関わると予測される遺伝子候補を見出した.良性GISTと悪性GISTの間で現在蛋白レベルでも発現に違いがあるのか免疫組織染色で解析中である.
|
Report
(3 results)
Research Products
(6 results)