The role of high mobility group A proteins in cancers

• Project/Area Number: 19790945
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: WATANABE Sugiko Kumamoto University, 発生医学研究センター, 助教 (10433012)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: HMGA / 癌 / エピジェネティクス / 膵臓癌 / 上皮間葉転換 / RB

Research Abstract

構造的クロマチン因子high mobility group Aタンパク質(HMGA)の癌病態における分子作用機構と治療的アプローチとして、以下の3点についての知見が得られた。1)Retinoblastomaタンパク質(RB)との相互作用による異常増殖への作用。2)膵臓癌において、細胞接着因子E-cadherinの発現抑制性転写因子SNAIL発現活性化による、上皮間葉転換維持。3)let-7micro RNAによるHMGA遺伝子発現制御機構と膵臓癌表現型への影響。

Research Products

• [Journal Article] HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells (2009)
  • Author(s): Watanabe, S., Ueda, Y., Akaboshi, S., Hino, Y., Sekita, Y. and Nakao, M.
  • Journal Title: Am J Pathol 174 Pages: 854-868
  • Peer Reviewed
• [Journal Article] HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells (2009)
  • Author(s): Watanabe, S.
  • Journal Title: American Journal of Pathology 174 Pages: 854-868
  • Peer Reviewed
• [Journal Article] miRNAとエピジェネティクス (2008)
  • Author(s): 渡邉すぎ子、赤星慎一、渡邊丈久、中尾光善
  • Journal Title: 実験医学増刊号 26 Pages: 1562-1568
• [Journal Article] miRNAとエピジェネーティクス (2008)
  • Author(s): 渡邉すぎ子
  • Journal Title: 実験医学増刊号 26 Pages: 1562-1568
• [Journal Article] High mobility group protein HMGA1 inhibits retinoblastoma proteinmediated cellular G0 arrest (2007)
  • Author(s): Ueda, Y., Watanabe, S., Tei, S., Saitoh, N., Kuratsu, J. I., Nakao, M.
  • Journal Title: Cancer Sci 98 Pages: 1893-901
  • Peer Reviewed
• [Journal Article] High mobility group protein HMGAl inhibits retinoblastoma protein-mediated cellular GO arrest (2007)
  • Author(s): Ueda, Y., Watanabe, S., Tei. S., Saitoh, N., Kuratsu, J.-I., Nakao, M.
  • Journal Title: Cancer Science 98 Pages: 1893-1901
  • Peer Reviewed
• [Presentation] クロマチン因子による遺伝子・細胞制御機構 (2008)
  • Author(s): 中尾光善、石原宏、三代剛、日野信次朗、渡邉すぎ子、斉藤典子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] The Global-COE (2008)
  • Author(s): Sugiko Watanabe, Shin-ichi Akaboshi, Yuko Hino, and Mitsuyoshi Nakao
  • Organizer: International Summer Retreat
  • Place of Presentation: 阿蘇
  • Year and Date: 2008-08-28
• [Remarks]
  • URL: http://www.imeg.kumamoto-u.ac.jp/divisions/medical_cell_biology/
• [Remarks]
  • URL: http://www.imeg.kumamoto-u.ac.jp/divisions/medical_cell_biology/
• [Remarks]
  • URL: http://www.imeg.kumamoto-u.ac.jp/en/divisions/Medical_Cell_Biology/index.html