Gene set-based identification of oncogenic pathways related to relapse-related death in lung adenocarcinomas

• Project/Area Number: 19790969
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Nagoya University
• Principal Investigator: TOMIDA Shuta Nagoya University, 大学院医学系研究科, 助教 (10372111)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 肺癌 / マイクロアレイ / バイオインフォマティクス / オーダーメイド医療 / 感受性予測 / 予後予測 / 再発予測 / パスウェイ解析 / 再発

Research Abstract

研究代表者らは、"機能的に関連した一連の遺伝子セット"を解析単位とする解析手法を用いる事によって、肺腺癌の多様性に関する"ターゲットパスウェイ"の抽出に成功した。
この"ターゲットパスウェイ"を基にした判別モデルを用いて、独立した肺腺癌データを解析したところ、統計的に有意に、術後予後良好群と予後不良群に分類することができた。
また、肺腺癌細胞株を用いた検討により、"ターゲットパスウェイ"に対する阻害活性を持つ薬剤の感受性予測モデルの構築にも成功した。

Research Products

• [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis (2009)
  • Author(s): Tomida S, Takeuchi T, Shimada Y, Arima C, Matsuo K, Mitsudomi T, Yatabe Y, Takahashi T
  • Journal Title: J Clin Oncol
  • Peer Reviewed
• [Journal Article] Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses (2009)
  • Author(s): Ebi H, Tomida S, Takeuchi T, Arima C, Sato T, Mitsudomi T, Yatabe Y, Osada H, Takahashi T
  • Journal Title: Cancer Res
  • Peer Reviewed
• [Journal Article] Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis (2009)
  • Author(s): Tomida Shuta
  • Journal Title: Journal of Clinical Oncology (In press)
  • Peer Reviewed
• [Journal Article] Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada H, Tomida S, Yatabe Y, Tatematsu Y, Takeuchi T, Murakami H, Kondo Y, Sekido Y, Takahashi T
  • Journal Title: Cancer Res 68(6) Pages: 1647-1655
  • Peer Reviewed
• [Journal Article] Roles of achaete-scute homologue 1 in DKK 1 and E-cadherin repression and neuroendocrine differentiation in lung cancer (2008)
  • Author(s): Osada Hirotaka
  • Journal Title: Cancer Research 68(6) Pages: 1647-55
  • Peer Reviewed
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach (2007)
  • Author(s): Tomida S, Yanagisawa K, Koshikawa K, Yatabe Y, Mitsudomi T, Osada H, Takahashi T
  • Journal Title: Oncogene 26(31) Pages: 4600-4608
  • Peer Reviewed
• [Journal Article] A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer (2007)
  • Author(s): Yanagisawa K, Tomida S, Shimada Y, Yatabe Y, Mitsudomi T, Takahashi T
  • Journal Title: J Natl Cancer Inst 99(11) Pages: 858-867
  • Peer Reviewed
• [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1 (2007)
  • Author(s): Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Sekido Y, Tanimoto M, Yatabe Y, Takahashi T
  • Journal Title: Cancer Res 67(13) Pages: 6007-6011
  • Peer Reviewed
• [Journal Article] Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. (2007)
  • Author(s): Tomida Shuta
  • Journal Title: Oncogene 26 Pages: 4600-4608
  • Peer Reviewed
• [Journal Article] A 25-signal proteomic signature and outcome for patients with resectednon-small-cell lung cancer. (2007)
  • Author(s): Yanagisawa Kiyoshi
  • Journal Title: J Natl Cancer Inst 99 Pages: 858-867
  • Peer Reviewed
• [Journal Article] Lineage-specific dependency of lung adenocarcinomas on the lung developlnent regulator TTF-1. (2007)
  • Author(s): TaIIaka Hisaaki
  • Journal Title: Cancer Research 67 Pages: 6007-6011
  • Peer Reviewed
• [Journal Article] PCNA Mono-ubiquitination and Activation of Translesion DNA Polymerases by DNA Polymerase α
  • Author(s): Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Miao HQ, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T, Takahashi T
  • Journal Title: J Biochemistry
  • Peer Reviewed
• [Presentation] Gene set-based identification of oncogenic pathways related to relapse-related death in lung adenocarcinomas (2008)
  • Author(s): 冨田秀太
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Gene set-based identification of oncogenic pathways relatedto relause-related death in lune adenocarcinomas (2008)
  • Author(s): 冨田秀太
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] In Silico screening of differentially expressed microRNAs (2007)
  • Author(s): Tomida Shuta
  • Organizer: lung cancer AACR-NCI-EORTC International Conference
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2007-10-24
• [Presentation] In Silico screening of differentially expressed microRNAs in lung cancer (2007)
  • Author(s): Tomida Shuta
  • Organizer: AACR-NCI-EORTC International Conference
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2007-10-24
• [Presentation] バイオインフォマティクス手法を用いた肺癌のマイクロRNA発現解析 (2007)
  • Author(s): 冨田秀太
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] バイオインフォマティクス手法を用いた肺癌のマイクロRNA発現解析 (2007)
  • Author(s): 冨田秀太
  • Organizer: 第66回 日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物 (2007)
  • Inventor(s): 冨田秀太
  • Industrial Property Rights Holder: 冨田秀太
  • Filing Date: 2007-12-28
• [Patent(Industrial Property Rights)] 肺腺癌患者の術後再発を予測するための方法及び組成物 (2007)
  • Inventor(s): 冨田秀太・他
  • Industrial Property Rights Holder: 冨田秀太・他
  • Industrial Property Number: 2007-339214
  • Filing Date: 2007-12-28