The efficacy of Rho-kinase inhibitor on 24-hour heart preservation

• Project/Area Number: 19790975
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: University of Occupational and Environmental Health, Japan (2008); Kyushu University (2007)
• Principal Investigator: ETO Masataka University of Occupational and Environmental Health, Japan, 大学病院, 助教 (20419526)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: 心筋保護液 / 心移植 / Rho-kinase inhibitor / 心筋保護 / fasudil / 交差灌流モデル

Research Abstract

Rho kinase inhibitor(RKI)は近年虚血再灌流障害に対する有用性が報告され、注目されている。心筋保護液に投与したRKIが虚血再灌流障害を軽減し、心機能が改善されるか否かを検討した。家兎摘出心臓をUW液中に24時間保存後、血液交差灌流にて再灌流し、RKI投与群と非投与群間で心機能の比較を行った結果,RKI投与群において良好な心機能を有する傾向がみられ、長時間心保存後の虚血再灌流障害を軽減する可能性が示唆された。

Research Products

• [Journal Article] Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation (2008)
  • Author(s): Kobayashi M, Tanoue B aba H, Kimura S, Oda S, Taniguchi K, Tominaga R.
  • Journal Title: Journal of Thoracic and Cardiovascular Surgery. 136 Pages: 1586-1592
  • Peer Reviewed
• [Journal Article] Rho-kinase inhibitor improves cardiac function after 24hour heart preservation (2008)
  • Author(s): Kobayashi M
  • Journal Title: Journal of Thoracic and cardiovascular surgery 136 Pages: 1586-1592
  • Peer Reviewed
• [Presentation] 24時間心保存におけるRho-kinase inhibitorの心保護効果の検討 (2008)
  • Author(s): 小林真理子,江藤政尚
  • Organizer: 第38回日本心臓血管外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-02-20
• [Presentation] 24時間心保存におけるRho-kinase inhibitor の心保護効果の検討 (2008)
  • Author(s): 小林 真理子
  • Organizer: 日本心臓血管外科学会
  • Place of Presentation: 福岡市
  • Year and Date: 2008-02-20