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Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression

Research Project

Project/Area Number 19790979
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKitasato University

Principal Investigator

AMANO Hideki  Kitasato University, 医学部, 助教 (60296481)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsトロンボキサンA2 / 血管新生 / SDF-1 / VEGF / 血小板 / トロンボキ酸A2 / VEGFR1 / TXA2
Research Abstract

NieらはThromboxane A2が血管内皮細胞のTP受容体に作用し血管内皮細胞の遊走を促進させ腫瘍の血管新生及び転移形成を促進させると報告した(Biochemi. Biophy. Rese. Com 2000)。しかしながら、下肢虚血モデルを用いてThromboxane A2が血小板の凝集を増強させたと同時に血管新生を促進させた報告例はない。本実験で申請者は血小板凝集能の差のあるTP+/+、TP-/-で下肢虚血モデルを作成し、虚血部位の血管新生部位に血小板由来のVEGFとSDF-1が骨髄に作用しCXCR4+VEGFR1+造血前駆細胞を虚血組織に動員させ虚血の改善を増強することを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth.2009

    • Author(s)
      Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, NarumiyaS, Watanabe M, Majima M.
    • Journal Title

      Biochem Biophys Res Commun 382(4)

      Pages: 720-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression.2009

    • Author(s)
      Ohnuma Y, Toda M, Fujita M, Hosono K, Suzuki T, Ogawa Y, Amano H, Kitasato H, Hayakawa K, Majima M.
    • Journal Title

      Biomed Pharmacother . 63(2)

      Pages: 136-45

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide.2008

    • Author(s)
      Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M.
    • Journal Title

      Proc Natl Acad Sci U S A. 105(36)

      Pages: 13550-5

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide2008

    • Author(s)
      Toda M, Suzuki T, Hosono K, Hashiba S, Amano H, et.al.
    • Journal Title

      Proceeding National Accademy of Science 105

      Pages: 13550-13555

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ThromboxaneA2, TPreceptor, induces ischemic-angiogenesis response by platelet P-selectin that induces platelet attachment around endothelial2009

    • Author(s)
      天野英樹
    • Organizer
      日本微小循環学会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] TP receptor signaling enhances angiogenesis during ischemia via P-selectin mediated adhesion of platelets to endothelial cells2009

    • Author(s)
      天野英樹
    • Organizer
      微小循環学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Roles of ThromboxaneA2 receptor TP signaling in acuteischemia and SDF-1 and VEGF expression2008

    • Author(s)
      天野 英樹
    • Organizer
      第8回国際炎症学会
    • Place of Presentation
      コペンハーゲン
    • Year and Date
      2008-06-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression2007

    • Author(s)
      天野英樹
    • Organizer
      微小循環学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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