Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression

• Project/Area Number: 19790979
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Kitasato University
• Principal Investigator: AMANO Hideki Kitasato University, 医学部, 助教 (60296481)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: トロンボキサンA2 / 血管新生 / SDF-1 / VEGF / 血小板 / トロンボキ酸A2 / VEGFR1 / TXA2

Research Abstract

NieらはThromboxane A2が血管内皮細胞のTP受容体に作用し血管内皮細胞の遊走を促進させ腫瘍の血管新生及び転移形成を促進させると報告した(Biochemi. Biophy. Rese. Com 2000)。しかしながら、下肢虚血モデルを用いてThromboxane A2が血小板の凝集を増強させたと同時に血管新生を促進させた報告例はない。本実験で申請者は血小板凝集能の差のあるTP+/+、TP-/-で下肢虚血モデルを作成し、虚血部位の血管新生部位に血小板由来のVEGFとSDF-1が骨髄に作用しCXCR4+VEGFR1+造血前駆細胞を虚血組織に動員させ虚血の改善を増強することを明らかにした。

Research Products

• [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. (2009)
  • Author(s): Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, NarumiyaS, Watanabe M, Majima M.
  • Journal Title: Biochem Biophys Res Commun 382(4) Pages: 720-5
  • Peer Reviewed
• [Journal Article] Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression. (2009)
  • Author(s): Ohnuma Y, Toda M, Fujita M, Hosono K, Suzuki T, Ogawa Y, Amano H, Kitasato H, Hayakawa K, Majima M.
  • Journal Title: Biomed Pharmacother . 63(2) Pages: 136-45
  • Peer Reviewed
• [Journal Article] Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. (2008)
  • Author(s): Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M.
  • Journal Title: Proc Natl Acad Sci U S A. 105(36) Pages: 13550-5
  • Peer Reviewed
• [Journal Article] Neural system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide (2008)
  • Author(s): Toda M, Suzuki T, Hosono K, Hashiba S, Amano H, et.al.
  • Journal Title: Proceeding National Accademy of Science 105 Pages: 13550-13555
  • Peer Reviewed
• [Presentation] ThromboxaneA2, TPreceptor, induces ischemic-angiogenesis response by platelet P-selectin that induces platelet attachment around endothelial (2009)
  • Author(s): 天野英樹
  • Organizer: 日本微小循環学会
  • Place of Presentation: 東京
  • Year and Date: 2009-02-20
• [Presentation] TP receptor signaling enhances angiogenesis during ischemia via P-selectin mediated adhesion of platelets to endothelial cells (2009)
  • Author(s): 天野英樹
  • Organizer: 微小循環学会総会
  • Place of Presentation: 東京
• [Presentation] Roles of ThromboxaneA2 receptor TP signaling in acuteischemia and SDF-1 and VEGF expression (2008)
  • Author(s): 天野 英樹
  • Organizer: 第8回国際炎症学会
  • Place of Presentation: コペンハーゲン
  • Year and Date: 2008-06-19
• [Presentation] Roles of a Thromboxane A2 Receptor, TP signaling in acute ischemia and SDF-1, VEGF expression (2007)
  • Author(s): 天野英樹
  • Organizer: 微小循環学会総会
  • Place of Presentation: 京都