Development of a novel imaging method of the white matter in the central nervoussystem using sonoporation

• Project/Area Number: 19790997
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Osaka University
• Principal Investigator: KINOSHITA Manabu Osaka University, 医学部附属病院, 医員 (40448064)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 超音波 / 神経機能画像 / MRI / Sonoporation / 手術支援画像 / MRl

Research Abstract

当研究課題ではMRIならびに超音波の生物学的特性を生かし、中枢神経系における新規画像作成方法の開発を試みた。MRIでは拡散テンソル画像(DTI)を研究の中心に据え、また超音波では細胞内への生体物質の導入をこれに組み合わせた。本研究により超音波による外来物質の細胞内導入条件の最適化が可能となり、またMRI側での研究ではDTIの組織学的意味付けならびに他画像モダリティーとの組み合わせが可能である事が証明された。

Research Products

• [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11C-methionine positron emission tomography for glioma (2009)
  • Author(s): Kinoshita M*, Hashimoto N, Goto T, Yanagisawa T, Okita Y, Kagawa N, Kishima H, Tanaka H, Fujita N, Shimosegawa E, Hatazawa J, Yoshimine T
  • Journal Title: Neuroimage 45 (2) Pages: 312-318
  • Peer Reviewed
• [Journal Article] Use of fractional anisotropy for determination of the cut-off value in 11 C-methionine positron emission tomography for glioma (2009)
  • Author(s): Kinoshita M, Hashimoto N, Goto T, Yanagisawa T, Okita Y, Kagawa N, Kishima H, Tanaka H, Fujita N, Shimosegawa E, Hatazawa J, Yoshimine T
  • Journal Title: Neuroimage 45 Pages: 312-318
  • Peer Reviewed
• [Journal Article] Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors (2008)
  • Author(s): Kinoshita M*, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T
  • Journal Title: Neuroimage 43 (1) Pages: 29-35
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas: A study comparing primary CNS malignant- and CNS intravascular lymphomas (2008)
  • Author(s): Kinoshita M*, Izumoto S, Hashimoto N, Kishima H, Kagawa N, Hashiba T, Chiba Y, Yoshimine T
  • Journal Title: Brain Tumor Pathol 25 (2) Pages: 73-78
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of adhesion molecules and matrix metalloproteinases in malignant CNS lymphomas : A study comparing primary CNS malignant- and CNS intravascular lymphomas (2008)
  • Author(s): Kinoshita M, Izumoto S, Hashimoto N, Kishima H, Kagawa N, Hashiba T, Chiba Y, Yoshimine T
  • Journal Title: Brain Tumor Pathology 25 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Fractional anisotropy and tumor cell density of the tumor core show positive correlation in diffusion tensor magnetic resonance imaging of malignant brain tumors (2008)
  • Author(s): Kinoshita M, Hashimoto N, Goto T, Kagawa N, Kishima H, Izumoto S, Tanaka H, Fujita N, Yoshimine T
  • Journal Title: Neuroimage 43 Pages: 29-35
  • Peer Reviewed
• [Journal Article] Key Factors That Affect Sonoporation Efficiency in in vitro Settings; The Importance of Standing Wave in Sonoporation (2007)
  • Author(s): Kinoshita M*, Hynynen K
  • Journal Title: Biochem Biophys Res Commun 359(4) Pages: 860-865
  • Peer Reviewed
• [Journal Article] Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2 (2007)
  • Author(s): Kinoshita M*, Eguchi Y, Hynynen K
  • Journal Title: Biochem Biophys Res Commun 353(2) Pages: 515-521
  • Peer Reviewed
• [Journal Article] Activation of Bak in ultrasound-induced, JNK-and p38-independent apoptosis and its inhibition by Bcl-2 (2007)
  • Author(s): Kinoshita M
  • Journal Title: Biochem Biophys Res Commun 353 Pages: 515-521
  • Peer Reviewed
• [Journal Article] Key Factors That Affect Sonoporation Efficiency in in vitro Settings ; The Importance of Standing Wave in Sonoporation (2007)
  • Author(s): Kinoshita M
  • Journal Title: Biochem Biophys Res Commun 359 Pages: 860-865
  • Peer Reviewed
• [Journal Article] Spontaneous Regression of a Spinal Extradural Arteriovenous Fistula After Delivery by Cesarean Section -Case Report-
  • Author(s): Kinoshita M*, Asai A, Komeda S, Yoshimura K, Takeda J, Uesaka T, Yamanouchi Y, Kanzaki H, Kawamoto K
  • Journal Title: Neurol Med Chir (in press)
  • NAID: 10025948198
  • Peer Reviewed
• [Journal Article] Spontaneous Regression of a Spinal Extradural Arteriovenous Fistula After Delivery by Cesarean Section -Case Report-
  • Author(s): Kinoshita M, Asai A, Komeda S, Yoshimura K, Takeda J, Uesaka T, Yamanouchi Y, Kanzaki H, Kawamoto K
  • Journal Title: Neurologia medico-chirurgica (in press)
  • NAID: 10025948198
  • Peer Reviewed
• [Presentation] Use of fractional anisotropy for determination of the cut-off value in methionine PET (2009)
  • Author(s): 木下学、後藤哲、柳澤琢史、沖田典子、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
  • Organizer: 第32回日本脳神経CI学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-06
• [Presentation] MRIによる脳腫瘍の生物学的特性の評価-拡散テンソル画像(DTI)による細胞密度、増殖能の評価とFDG-PETとの相関性 (2008)
  • Author(s): 木下学、沖田典子、後藤哲、山本福子、千葉泰良、香川尚己、貴島晴彦、橋本直哉、吉峰俊樹
  • Organizer: 第26回日本脳腫瘍学会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-12-02
• [Presentation] MRIによる脳腫瘍の生物学的特性の評価の試み -拡散テンソル画像(DTI)による細胞密度、増殖能の評価- (2008)
  • Author(s): 木下学、橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、香川尚己、貴島晴彦、吉峰俊樹
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 盛岡
  • Year and Date: 2008-10-03
• [Presentation] MRIによる脳腫瘍の生物学的特性の評価の試み-拡散テンソル画像(DTI)による細胞密度、増殖能の評価- (2008)
  • Author(s): 木下学、橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、香川尚己、貴島晴彦、吉峰俊樹
  • Organizer: 第67回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-03
• [Presentation] The correlation of tumor cell density and diffusion tensor imaging (2008)
  • Author(s): 木下学、橋本直哉、後藤哲、沖田典子、山本福子、千葉泰良、香川尚己、貴島晴彦、泉本修一、吉峰俊樹
  • Organizer: 第26回日本脳腫瘍病理学会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] 超音波の生体作用(ソノポレーション、アポトーシス、薬物輸送) (2008)
  • Author(s): 木下学
  • Organizer: 第81回日本超音波医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2008-05-23
• [Presentation] 脊髄動静脈瘻診断におけるContrast-enhanced MR Angiographyの有用性 (2008)
  • Author(s): 木下学、吉村晋一、武田純一、上坂達郎、淺井昭雄、山内康雄、河本圭司
  • Organizer: 第31回日本脳神経CI学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-21
• [Presentation] 脊髄動静脈瘻診断におけるContract-enhanced MR Angiographyの有用性 (2008)
  • Author(s): 木下学
  • Organizer: 第31回日本脳神経CI学会
  • Place of Presentation: 東京
  • Year and Date: 2008-02-21
• [Presentation] 中枢神経系悪性リンパ腫の接着因子ならびに組織破壊因子の発現に関する検討 (2007)
  • Author(s): 木下学、泉本修一、橋本直哉、貴島晴彦、香川尚己、羽柴哲夫、千葉泰良、吉峰俊樹
  • Organizer: 第25回日本脳腫瘍学会
  • Place of Presentation: 東京
  • Year and Date: 2007-12-09
• [Presentation] 集束超音波を用いたMR画像誘導下での脳へのDrug Deliveryの可能性 (2007)
  • Author(s): 木下学、吉峰俊樹、浅井昭雄、Nathan McDannold、Ferenc Jolesz、Kullervo Hynynen
  • Organizer: 第66回日本脳神経外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-04
• [Presentation] 頭蓋内血管内リンパ腫における免疫組織学的検討 (2007)
  • Author(s): 木下学、泉本修一、橋本直哉、貴島晴彦、香川尚己、羽柴哲夫、千葉泰良、吉峰俊樹
  • Organizer: 第25回日本脳腫瘍病理学会
  • Place of Presentation: 熊本
  • Year and Date: 2007-04-20
• [Book] MRI-Guided Focused Ultrasound Surgery (Jolesz FA, Hynynen K eds) (Targeted Drug Delivery) (147-159) (2007)
  • Author(s): Kinoshita M
  • Publisher: Informa healthcare
• [Book] MRI-Guided Focused Ultrasound Surgery (Jolesz FA, Hynynen K eds) (Ultrasound-Induced Apoptosis) (181-194) (2007)
  • Author(s): Vykhodtseva N, Kinoshita M
• [Book] MRI-Guided Focused Ultrasound Surgery (2007)
  • Author(s): Kinoshita M
  • Publisher: Informa healcare
• [Remarks] ホームページ等
  • URL: http://www.manabukinoshita.com
• [Remarks] web page
  • URL: http://www.manabukinoshita.com