• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

the interaction between phosphorylation of p53 and selectivity of p53-target genes in human glioma cells

Research Project

Project/Area Number 19791002
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKyushu University

Principal Investigator

AMANO Toshiyuki  Kyushu University, 大学院・医学研究院, 助教 (70448413)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords脳腫瘍学 / p53 遺伝子 / セリン残基 / リン酸化 / グリオーマ / アポトーシス / Caspase / Fas / PUMA
Research Abstract

ヒトグリオーマ細胞株におけるp53誘導性のアポトーシスには、p53の15番目と20番目のセリン残基のリン酸化が深く関与しており、両セリン残基のリン酸化が同時に起こった場合には、それだけで十分にp53誘導性のアポトーシスが引き起こされる。その際にはp53標的遺伝子の一つであるFasおよびPUMA遺伝子の転写活性が選択的に上昇し、各々death receptor pathwayとmitochondrial pathwayを経由してp53誘導性のアポトーシスが惹起される。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (3 results)

All 2009 2008

All Journal Article (3 results)

  • [Journal Article] Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes2009

    • Author(s)
      Amano T, Nakamizo A, Mishra SK, Gumin J, Shinojima N, Sawaya R, Lang FF
    • Journal Title

      Journal of Neuro-Oncology 92

      Pages: 357-371

    • Related Report
      2008 Final Research Report
  • [Journal Article] Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis2008

    • Author(s)
      Nakamizo A, Amano T, Zhang W, Zhang XQ, Ramdas L, Liu TJ, Bekele BN, Shono T, Sasaki T, Benedict WF, Sawaya R, Lang FF
    • Journal Title

      Neuro-Oncology 10

      Pages: 275-91

    • Related Report
      2008 Final Research Report
  • [Journal Article] Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis2008

    • Author(s)
      Nakamizo et.al.
    • Journal Title

      Neuro-Oncology 10

      Pages: 275-291

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi