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The role of gap junction for glutamate re-uptake in penumbral region

Research Project

Project/Area Number 19791008
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNara Medical University

Principal Investigator

TAMURA Kentaro  Nara Medical University, 医学部, 助教 (00423913)

Co-Investigator(Renkei-kenkyūsha) NAKASE Hiroyuki  奈良県立医科大学, 医学部, 教授 (10217739)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,740,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsペナンブラ / スプレディング・デプレッション / 静脈梗塞 / 脳神経疾患 / 脳循環代謝
Research Abstract

脳梗塞周辺のペナンブラ領域において発生するスプレディング・デプレッションは神経細胞損傷を増悪させる.ラット脳皮質静脈閉塞モデルを用いペナンブラ類似領域を作成し,ギャップジャンクションブロッカーを投与後,スプレディング・デプレッションを発生させると,発生する静脈梗塞が拡大した.これはペナンブラ領域においてギャップジャンクションはスプレディング・デプレッションに対して細胞保護的に働いていることを示す.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2007

All Presentation (5 results)

  • [Presentation] Neuroprotection in experimental model of cerebral venous infarct2007

    • Author(s)
      Nakase H., Tamura K., Tamaki R., Nishioka T., Kimura R., Sakaki T., Heimann A., Kempski O
    • Organizer
      The 2nd Meeting of Asian Stroke Forum
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-09-27
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Glial gap-junctions in the rat brain : Are they essential for brain function during brain ischemia ?2007

    • Author(s)
      Tamura K., Tamaki R., Nakase H., Sakaki T., Alessandri B., Heimann A., Kempski O
    • Organizer
      The 23rd International Symposium on Cerebral Blood flow, Metabolism and Function & The 8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Novel neuroprotectivtice approaches in experimental model of cerebral venous infarction.2007

    • Author(s)
      Nakase H., Tamura K., Tamaki R., Nishioka T., Kimura R., Sakaki T., Heimann A., Kempski O
    • Organizer
      The 23rd International Symposium on Cerebral Blood flow, Metabolism and Function & The 8th International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] Glial gap-junctions in the rat brain :Are they essential for brain function during brain ischemia?.2007

    • Author(s)
      Tamura K.
    • Organizer
      The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Funcion & The 8t International Conference on Quantification of Brain Function with PET
    • Place of Presentation
      Osaka
    • Year and Date
      2007-05-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Spreading depressionの脳梗塞増大効果におけるgap junctionの役割2007

    • Author(s)
      田村 健太郎
    • Organizer
      第32回日本脳卒中学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2007-03-23
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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