Inflammation and hyponatremia in vasospasm after aneuriymal subarachnoid hemorrhage
| Project/Area Number |
19791009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
KUBO Yoshitaka Iwate Medical University, 医学部, 講師 (00316366)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥2,930,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | くも膜下出血 / 脳血管攣縮 / 炎症性接着分子 / 低Na血症 / アドレノメデュリン / subarachnoid hemorrhe / delaed ischemic neuroloical deficits / adrenomedullin / honatremia / adhesion molecule / hih-sensitivity C-reactive protein / 高感度CRP |
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| Research Abstract |
(1)血清intercellular adhesion molecules (ICAM)-1, vascular cell adhesion molecule (VCAM)-1,高感度CRPはくも膜下出血患者で上昇し、症候性脳血管攣縮に相関する可能性がある。
(2)髄液アドレノメデュリンは脳血管攣縮期に脳灌流圧を改善させるために上昇すると考えられるが、逆に腎交感神経を抑制してNa利尿を促し、低Na血症と症候性脳血管攣縮をきたす可能性があると考えられた。
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Report
(3 results)
Research Products
(14 results)
