Inflammation and hyponatremia in vasospasm after aneuriymal subarachnoid hemorrhage

• Project/Area Number: 19791009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Iwate Medical University
• Principal Investigator: KUBO Yoshitaka Iwate Medical University, 医学部, 講師 (00316366)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,930,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: くも膜下出血 / 脳血管攣縮 / 炎症性接着分子 / 低Na血症 / アドレノメデュリン / subarachnoid hemorrhe / delaed ischemic neuroloical deficits / adrenomedullin / honatremia / adhesion molecule / hih-sensitivity C-reactive protein / 高感度CRP

Research Abstract

(1)血清intercellular adhesion molecules (ICAM)-1, vascular cell adhesion molecule (VCAM)-1,高感度CRPはくも膜下出血患者で上昇し、症候性脳血管攣縮に相関する可能性がある。
(2)髄液アドレノメデュリンは脳血管攣縮期に脳灌流圧を改善させるために上昇すると考えられるが、逆に腎交感神経を抑制してNa利尿を促し、低Na血症と症候性脳血管攣縮をきたす可能性があると考えられた。

Research Products

• [Journal Article] Ruptured cerebral fusiform aneurysm with mucopolysaccharide deposits in the media in a patient with Marfan's syndrome Journal of Neurosurgery (2009)
  • Author(s): Kubo Y, Ogasawara K, Kurose A, Kakino S, Tomitsuka N, Ogawa A
  • Journal Title: 110 Pages: 518-520
• [Journal Article] Cerebrospinal Fluid Adrenomedullin Concentration Correlates with Hyponatremia and Delaye d Ischemic Neurological Deficits after Subarachnoid Hemorrhage (2009)
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashi mura H, Yoshida K, Ogawa A.
  • Journal Title: Cerebrovascular Diseases 25 Pages: 164-169
  • Peer Reviewed
• [Journal Article] Ruptured cerebral fusiform aneurysm with mucopolysaccharide deposits in the media in a patient with Marfan's syndrome: Case renort (2009)
  • Author(s): Kubo Y, Ogasawara K, Kurose A, Kakin o S, Tomitsuka N. Ogawa A.
  • Journal Title: Journal of Neurosurgery 110 Pages: 518-520
  • Peer Reviewed
• [Journal Article] Cerebrospinal Fluid Adrenomedullin Concentration Correlates with Hyponatremia and Delayed Ischemic Neurological Deficits after Subarachnoid Hemorrhage (2008)
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashimura H, Yoshida K, Ogawa A
  • Journal Title: Cerebrovascular Diseases 25 Pages: 164-169
• [Journal Article] Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurological deficits after subarachnoid hemorrhage (2008)
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashimura H, Tomitsuka N, Sugawara A, Ogawa A
  • Journal Title: Surgical Neurology 69 Pages: 592-596
• [Journal Article] Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurological deficits after subarachnoid hemorrhage (2008)
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashi mura H, Tomitsuka N, Sugawara A, Ogawa A.
  • Journal Title: Surgical Neurology 69 Pages: 592-596
  • Peer Reviewed
• [Journal Article] Cerebrospinal fluid adrenomedullin concentration correlates with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage (2008)
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashimura H, Yoshida K, Ogawa A
  • Journal Title: Cerebrovascular Diseases 25 Pages: 164-169
  • Peer Reviewed
• [Journal Article] Ruptured cerebral fusiform aneurysm with mucopolysaccharide deposits in the media in a patient with Marfan's syndrome (2008)
  • Author(s): Kubo Y, Ogasawara K, Kurose A, Kakino S, Tomitsuka N, Ogawa A
  • Journal Title: Journal of Naurosurgery (in press)
  • Peer Reviewed
• [Journal Article] Serum inflammatory adhesion molecules and high-sensitivity C-reactive protein correlates with delayed ischemic neurological deficits after subarachnoid hemorrhage
  • Author(s): Kubo Y, Ogasawara K, Kakino S, Kashimura H, Tomitsuka N, Sugawara A, Ogawa A
  • Journal Title: Surgical Neurology (in press)
  • Peer Reviewed
• [Presentation] くも膜下出血患者における髄液中アドレノメデュリンの存在意義-低Na血症と症候性脳血管攣縮との関連- (2009)
  • Author(s): 久保慶高
  • Organizer: 第26回スパスムシンポジウム
  • Place of Presentation: 島根県松江市
  • Year and Date: 2009-03-20
• [Presentation] くも膜下出血患者における炎症性接着分子と高感度CRPの意義 (2008)
  • Author(s): 久保慶高
  • Organizer: 第37回脳卒中の外科
  • Place of Presentation: 京都府京都市
  • Year and Date: 2008-03-21
• [Presentation] Cerebrospinal fluid adrenomedullin concentration correlates with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage (2007)
  • Author(s): 久保慶高
  • Organizer: 第66回日本脳神経外科学会総会
  • Place of Presentation: グランドプリンスホテル高輪
  • Year and Date: 2007-10-05
• [Book] 安全なドレーン管理 (2008)
  • Author(s): 久保慶高
  • Total Pages: 6
  • Publisher: メディカ出版
• [Book] Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (cochrane review) (2007)
  • Author(s): 久保慶高、小川 彰
  • Total Pages: 4
  • Publisher: 先端医学社