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Pathophysiology and Hemodynamics of Cerebral aneurysms

Research Project

Project/Area Number 19791010
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionThe University of Tokyo (2009)
Jichi Medical University (2007-2008)

Principal Investigator

SHOJIMA Masaaki  Jichi Medical University, 医学部附属病院, 助教 (80376425)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords脳動脈瘤 / 血行力学 / 流体力学 / シミュレーション / 血行力学的ストレス / せん断応力 / アテローム硬化 / 脳神経外科 / 脳血管内外科学 / 医用工学
Research Abstract

In this research, 82 unruptured cerebral aneurysms were followed with catheter-based 3D rotational angiography, and among them, blister formation was documented in 4 aneurysm during the 10.1 months observation. Three of them could be analyzed here to characterize the hemodynamic features associated with the blister formation. Blister formation occurred at the area of low shear magnitude and high shear gradient. Our findings would contribute to reveal the hemodynamic features leading to the aneurysm progression and provide the basis of the aneurysm treatment via flow alteration.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2009 2008 2007 Other

All Journal Article (7 results) Presentation (12 results)

  • [Journal Article] 脳動脈瘤の発生機序(流体力学的考察を含めて)2008

    • Author(s)
      庄島正明
    • Journal Title

      Pharma Media 26(印刷中)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 脳動脈瘤の血行力学2007

    • Author(s)
      庄島正明
    • Journal Title

      脳神経外科速報 第17巻

      Pages: 592-599

    • Related Report
      2009 Final Research Report
  • [Journal Article] Three-dimensional Rotational Angiography Basic and Advanced Application in Interventional Neuroradiology2007

    • Author(s)
      Masaaki Shojima, Takahiro Miyata, Shigeru Nemoto
    • Journal Title

      第22回日本脳神経血管内治療学会総会講演集

      Pages: 40734-40734

    • Related Report
      2009 Final Research Report
  • [Journal Article] 脳動脈瘤の血流解析におけるSCRYU/Tetra systemの役割2007

    • Author(s)
      庄島正明
    • Journal Title

      ソフトウェアクレイドルユーザーカンファレンス2007プロシーディング D2_1-D2_13

    • Related Report
      2009 Final Research Report
  • [Journal Article] 脳動脈瘤の発生機序(流体力学的考察を含めて)2007

    • Author(s)
      庄島正明
    • Journal Title

      Pharma Medica

      Pages: 17-20

    • Related Report
      2009 Final Research Report
  • [Journal Article] 脳動脈瘤の血行力学2007

    • Author(s)
      庄島正明
    • Journal Title

      脳神経外科速報 17

      Pages: 592-599

    • Related Report
      2007 Annual Research Report
  • [Journal Article] コンピューターシミュレーションを用いた脳動脈瘤内部における血流動態の解析

    • Author(s)
      庄島正明
    • Journal Title

      自治医科大学紀要 第30巻

      Pages: 187-188

    • Related Report
      2009 Final Research Report
  • [Presentation] Flow dynamics and endovascular treatment of cerebral aneurysms2009

    • Organizer
      9^<th> International Conference on Cerebrovascular Surgery
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Flow dynamics & Endovascular treatment of Cerebral aneurysms2009

    • Author(s)
      Masaaki Shojima
    • Organizer
      International Conference on Cerebrovascular surgery(ICCVS 2009)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳動脈瘤の血行力学的ストレスとブレブの形成2009

    • Organizer
      第68回日本脳神経外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳動脈瘤が増大し破裂へ至る過程における血行力学的ストレスの役割2008

    • Organizer
      第24回日本脳神経血管内治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-13
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 脳動脈瘤が破裂へ至る過程における血行力学的ストレスの関わり2008

    • Organizer
      第67回日本脳神経外科学会総会
    • Place of Presentation
      岩手
    • Year and Date
      2008-10-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Hemodynamic analysis of the aneurysms which later ruptured or enlarged2008

    • Organizer
      5^<th> International Intracranial Stent Meeting -ICS08
    • Place of Presentation
      Ankara, Turkey
    • Year and Date
      2008-05-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Hemodynamic analysis of the aneurysms which later ruptured or enlarged2008

    • Author(s)
      Masaaki Shojima
    • Organizer
      Intracranial Stent Meeting 2008
    • Place of Presentation
      Ankara, Turkey
    • Year and Date
      2008-05-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳動脈瘤破裂部位における血行力学的ストレス2007

    • Organizer
      第23回日本脳神経血管内治療学会
    • Place of Presentation
      兵庫
    • Year and Date
      2007-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳動脈瘤に作用する壁面せん断応力の大きさと役割2007

    • Organizer
      第23回日本脳神経外科血管内治療学会
    • Place of Presentation
      兵庫
    • Year and Date
      2007-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳動脈瘤の血流解析におけるSCRYU/Tetra systemの役割2007

    • Organizer
      ソフトウェアクレイドルユーザーカンファレンス
    • Place of Presentation
      東京
    • Year and Date
      2007-10-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳動脈瘤の血行力学2007

    • Organizer
      第53回関東脳神経外科懇話会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Flow impingement and rupture of cerebral aneurysms2007

    • Organizer
      4th International Intracranial Stent Meeting -ICS07
    • Place of Presentation
      Kyoto
    • Year and Date
      2007-04-19
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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