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Basic Approach for clarification of etiology of diseases of growth plate

Research Project

Project/Area Number 19791018
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka City University

Principal Investigator

IMAI Yuuki  Osaka City University, 大学院・医学研究科, 病院講師 (10423873)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,840,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥540,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords核内受容体 / 軟骨 / 大腿骨頭すべり症 / 遺伝子改変マウス
Research Abstract

骨軟骨組織における核内受容体高次機能解明を目的として、軟骨組織特異的核内受容体遺伝子欠損マウス作出するために、9型コラーゲン(Col9)遺伝子座にCreRecombinaseを挿入したCol9-Cre(CreERT2)ノックインマウス作出のためのTargeting Vectorを完成させたが、ES細胞に遺伝子導入した結果、遺伝子組み換え効率が非常に悪く、Southern blotting法による確認により、組み換え体のES細胞を得られなかった。そこで、従来のエレクトロポレーション法ならびにREDシステムによる遺伝子組み換えによるTargeting Vectorの作成から、Invitrogen社製、BP recombinaseおよびLR recombinaseを用いたTargeting Vector作成に切り替え、Targeting Vectorが完成し、すべての塩基配列を確認後、現在ES細胞への遺伝子導入により、組み換え体の作出を行っている段階であり、残念ながら報告時点で、Col9-Creノックインマウスの作出には至っていない。また、PPARγ floxマウスはバッククロスが進んでいる。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (85 results)

All 2009 2008 2007 Other

All Journal Article (31 results) (of which Peer Reviewed: 12 results) Presentation (42 results) Book (2 results) Remarks (10 results)

  • [Journal Article] Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3', 5'-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells2009

    • Author(s)
      Nakao S, Koike T, Ohta Y, Manaka T, Imai Y, Takaoka K
    • Journal Title

      Bone (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] RNA Interference for Noggin Enhances the Biological Activity of Bone Morphogenetic Proteins in vivo and in vitro2009

    • Author(s)
      Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K
    • Journal Title

      J Bone Miner Metab (in press)

    • NAID

      10027204830

    • Related Report
      2008 Final Research Report
  • [Journal Article] Osteoinductive Capacity and Heat Stability of Recombinant Human Bone Morphogenetic Protein-2 Produced by Escherichia coli and Dimerized by Biochemical Processing2009

    • Author(s)
      Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K
    • Journal Title

      J Bone Miner Metab (in press)

    • NAID

      10025337547

    • Related Report
      2008 Final Research Report
  • [Journal Article] Molecular Mechanisms Underlying the Effects of Sex Steroids on Bone and Mineral Metabolism2009

    • Author(s)
      Imai Y, Nakamura T, Matsumoto T, Takaoka K, Kato S
    • Journal Title

      J Bone Miner Metab (in press)

    • NAID

      10025336521

    • Related Report
      2008 Final Research Report
  • [Journal Article] Regulation of Bone Metabolism by Nuclear Receptors2009

    • Author(s)
      Imai Y, Kondoh S, KouzmenkoA, Kato S
    • Journal Title

      Mol Cell Endocrinol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA Interference for Noggin Enhances the Biological Activity of Bone Morphogenetic Proteins in vivo and in vitro2009

    • Author(s)
      Takayama K, Suzuki A, Manaka T, Taguchi S, Hashimoto Y, Imai Y, Wakitani S, Takaoka K
    • Journal Title

      J Bone Miner Metab (In press)

    • NAID

      10027204830

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoinductive Capacity and Heat Stability of Recombinant Human Bone Morphogenetic Protein-2 Produced by Escherichia coli and Dimerized by Biochemical Processing2009

    • Author(s)
      Yano K, Hoshino M, Ohta Y, Manaka T, Naka Y, Imai Y, Sebald W, Takaoka K
    • Journal Title

      J Bone Miner Metab (In press)

    • NAID

      10025337547

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Mechanisms Underlying the Effects of Sex Steroids on Bone and Mineral Metabolism2009

    • Author(s)
      Imai Y, Nakamura T, Matsumoto T, Takaoka K, Kato S
    • Journal Title

      J Bone Miner Metab (In press)

    • NAID

      10025336521

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts2009

    • Author(s)
      Imai Y, Youn MY, Kondoh S, Nakamura T, Kouzmenko A, Matsumoto T, Takada I, Takaoka K, Kato S
    • Journal Title

      Annals of New York Academy of Sciences (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel LMXIB nonsense mutation in a family with nail-patella syndrome2009

    • Author(s)
      Oshimo T, Fukai K, Higashi N, Kitano T, Imai Y, Shintaku H, Ishii M
    • Journal Title

      J Dermatol Sci 52

      Pages: 57-60

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estrogens Maintain Bone Mass by Regulating Expression of Genes Controlling Function and Life Span in Mature Osteoclasts2008

    • Author(s)
      Imai Y, Youn MY, Kondoh S, Nakamura T, Kouzmenko A, Matsumoto T, Takada I, Takaoka K, Kato S
    • Journal Title

      Annals of New York Academy of Sciences (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Regulation of Bone Metabolism by Nuclear Receptors2008

    • Author(s)
      Imai Y, Kondoh S, Kouzmenko A, Kato S
    • Journal Title

      Mol Cell Endocrinol (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB2008

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
    • Journal Title

      J Bone Miner Metab 26(5)

      Pages: 478-84

    • Related Report
      2008 Final Research Report
  • [Journal Article] A novel LMX1B nonsense mutation in a family with nail-patella syndrome.2008

    • Author(s)
      Oshimo T, Fukai K, Higashi N, Kitano T, Imai Y, Shintaku H, Ishii M.
    • Journal Title

      J Dermatol Sci 52(1)

      Pages: 57-60

    • NAID

      10024457342

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.2008

    • Author(s)
      Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
    • Journal Title

      Science 319(5863)

      Pages: 624-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB2008

    • Author(s)
      Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
    • Journal Title

      J Bone Miner Metab 26

      Pages: 478-484

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児化膿性股関節炎の治療経験2008

    • Author(s)
      森田光明, 中村博亮, 北野利夫, 今井祐記, 高岡邦夫
    • Journal Title

      日本小児整形外科学会雑誌 47

      Pages: 46-49

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エストロゲン標的細胞としての破骨細胞2008

    • Author(s)
      今井祐記, 金藤紫乃, 延〓栄, 高岡邦夫, 加藤茂明
    • Journal Title

      内分泌・糖尿病科 27

      Pages: 258-263

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 骨再生の現状と展望〜BMPを中心に〜2008

    • Author(s)
      今井祐記, 高岡邦夫
    • Journal Title

      Chnical Calcium 18

      Pages: 1693-1700

    • Related Report
      2008 Annual Research Report
  • [Journal Article] エストロゲン受容体とメカニカルストレス2008

    • Author(s)
      今井祐記, 金藤紫乃, 加藤茂明
    • Journal Title

      Clinical Calcium 18

      Pages: 1272-1277

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 【整形外科における最近の進歩と展望】代謝性骨疾患2008

    • Author(s)
      高岡邦夫, 今井祐記, 今西康雄, 小池達也
    • Journal Title

      整形外科 59

      Pages: 725-732

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Expression profiles of phosphodiesterase 4D splicing variants in osteoblastic cells.2008

    • Author(s)
      Nomura-Furuwatari C, Wakitani S, Hashimoto Y, Imai Y, Ohta Y, Nakagawa K, Nakao Y, Takayama K, Manaka T, Takaoka K.
    • Journal Title

      J Bone Miner Metab 26

      Pages: 152-158

    • NAID

      10024126436

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.2008

    • Author(s)
      Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H
    • Journal Title

      Science. 319

      Pages: 624-627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エストロゲンは破骨細胞におけるエストロゲン受容体αを介したFasリガンドの誘導により骨量の減少を阻害する2008

    • Author(s)
      今井 祐記, 中村 貴, 松本 高広, 加藤 茂明
    • Journal Title

      実験医学 26

      Pages: 413-416

    • Related Report
      2007 Annual Research Report
  • [Journal Article] エストロゲンは破骨細胞寿命調節により骨量を維持する2008

    • Author(s)
      今井 祐記, 中村 貴, 松本 高広, 加藤 茂明
    • Journal Title

      細胞工学 27

      Pages: 54-55

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fasligand in osteoclasts2007

    • Author(s)
      Nakamura T*, Imai Y*, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. (*; These authors equally contributed to this work)
    • Journal Title

      Cell 130(5)

      Pages: 811-23

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation2007

    • Author(s)
      Nakagawa K, Imai Y, Ohta Y, Takaoka K
    • Journal Title

      Bone 41(4)

      Pages: 543-8

    • Related Report
      2008 Final Research Report
  • [Journal Article] Calcanealapophyseal avulsion fracture2007

    • Author(s)
      Imai Y, Kitano T, Nakagawa K, Takaoka K
    • Journal Title

      ArchOrthopTraumaSurg 127(5)

      Pages: 331-3

    • Related Report
      2008 Final Research Report
  • [Journal Article] Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts2007

    • Author(s)
      Nakamura T^*, Imai Y^*, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y Krust A, Yamamoto Y Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S.(*;These authors contributed equally to this work.)
    • Journal Title

      Cell 130

      Pages: 811-823

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation2007

    • Author(s)
      Nakagawa K, ImaiY, Ohta Y, Takaoka K.
    • Journal Title

      Bone 41

      Pages: 543-548

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 創意と工夫 大腿骨頭すべり症に対するナビゲーションシステムを用いた現位置2007

    • Author(s)
      中川 敬介, 北野 利夫, 今井 祐記, 高岡 邦夫
    • Journal Title

      整形外科 58

      Pages: 1767-1771

    • Related Report
      2007 Annual Research Report
  • [Presentation] Osteoblastic Androgen Receptor Regulates Cortical Bone Mineral Density2009

    • Author(s)
      Imai Y, Nakamura T, Matsumoto T, Inoue K, Kondoh S, Sato T, Takaoka K, Kato S
    • Organizer
      ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Related Report
      2008 Annual Research Report
  • [Presentation] 破骨細胞特異的ERa-KO2008

    • Author(s)
      今井祐記 中村 貴 高岡邦夫 加藤茂明
    • Organizer
      マウスにおける骨粗鬆症発症機構
    • Place of Presentation
      千葉
    • Year and Date
      2008-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 破骨細胞特異的ERa-KOマウスにおける骨粗鬆症発症機構2008

    • Author(s)
      今井祐記, 中村貴, 高岡邦夫, 加藤茂明
    • Organizer
      日本老年医学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 閉経後骨粗鬆症の新たな分子メカニズム解明2008

    • Author(s)
      今井祐記
    • Organizer
      O2 カンファレンス
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 閉経後骨粗鬆症の新たな分子メカニズム解明2008

    • Author(s)
      今井祐記
    • Organizer
      O2カンファレンス
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] エストロゲンによる骨量維持機構の分子基盤2008

    • Author(s)
      今井祐記 中村貴 松本高広 高岡邦夫 加藤茂明
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      青森
    • Year and Date
      2008-05-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] SERM学術研究会学術集会2008

    • Author(s)
      今井祐記 中村貴 松本高広 高岡邦夫 加藤茂明
    • Organizer
      閉経後骨粗鬆症の分子メカニズム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-10
    • Related Report
      2008 Final Research Report
  • [Presentation] 閉経後骨粗鬆症の分子メカニズム2008

    • Author(s)
      今井祐記, 中村貴, 松本高広, 高岡邦夫, 加藤茂明
    • Organizer
      SERM学術研究会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Sex Steroids Hormone Mediate Osteoprotecitve Effects by Controlling Osteoclast Life Cycle2008

    • Author(s)
      Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Shingo Sato, Shu Takeda, Katsuhide Igarashi, Yoko Yamamoto, Jun Kanno Kunio Takaoka, T.John Mart in, Pierre Chambon, Shigeaki Kato
    • Organizer
      2008 IBMS Davos WOrkshop
    • Place of Presentation
      Davos
    • Year and Date
      2008-03-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生物学的骨癒合促進法2008

    • Author(s)
      今井祐記 高岡邦夫
    • Organizer
      骨折治療を考える会
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 生物学的骨癒合促進法2008

    • Author(s)
      今井 祐記 高岡 邦夫
    • Organizer
      骨折治療を考える会 第1回研修会
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bone Research Seminar Estrogen Prevents Bone Loss via Estrogen Receptor Alpha and Induction of FasLigand in Osteoclast2008

    • Author(s)
      今井祐記
    • Place of Presentation
      東京
    • Year and Date
      2008-02-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Estrogen Prevents Bone Loss via Estrogen Receptor Alpha and Induction of Fas Ligand in Osteoclasts2008

    • Author(s)
      今井 祐記
    • Organizer
      第2回Bone Research Seminar
    • Place of Presentation
      東京
    • Year and Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨芽細胞におけるエストロゲンの作用の解明-骨芽細胞特異的エストロゲン受容体欠損マウスを用いて2008

    • Author(s)
      金藤紫乃, 今井祐記, 高田伊知郎, 中村貴, 松本高広, 加藤茂明
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 思春期大腿骨頭変形に対する骨頭回転骨切り術2008

    • Author(s)
      今井祐記 江口佳孝 高岡邦夫 北野利夫 中川敬介
    • Organizer
      日本股関節学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 成熟破骨細胞におけるエストロゲン受容体ERαの発現解析2008

    • Author(s)
      延民榮 高田伊知郎 金藤紫乃 今井祐記 加藤茂明
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨芽細胞におけるエストロゲンの直接作用-骨芽細胞特異的エストロゲン受容体欠損マウスの作出2008

    • Author(s)
      金藤紫乃, 今井祐記, 高田伊知郎, 中村貴, 松本高広, 加藤茂明
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨折後炎症期における骨折治癒のメカニズム2008

    • Author(s)
      今井祐記 高岡邦夫
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Estrogen Mediates Osteoprotective Effects by Controlling Osteoclast Life Cycle2008

    • Author(s)
      Kato S, Imai Y, Nakamura T
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨組織におけるアンドロゲン受容体機能解明2008

    • Author(s)
      今井祐記 中村貴 金藤紫乃 松本高広 佐藤隆史 脇谷滋之 高岡邦夫 加藤茂明
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ASBMR Annual Meeting Biochemical Characterization of ERα Co-regulators in Multinucleated Mature Osteoclasts2008

    • Author(s)
      Takada I, Youn MY, Imai Y, Kato S
    • Organizer
      Montreal
    • Place of Presentation
      CANADA
    • Related Report
      2008 Final Research Report
  • [Presentation] ASBMR Annual Meeting Multinuclear Expression of ERα in Mature Osteoclasts2008

    • Author(s)
      Youn MY, Takada I, Kondoh S, Imai Y, Kato S
    • Organizer
      Montreal
    • Place of Presentation
      CANADA
    • Related Report
      2008 Final Research Report
  • [Presentation] ASBMR Annual Meeting Osteoblastic Androgen Receptor Regulates Cortical Bone Mineral Density2008

    • Author(s)
      Imai Y, Nakamura T, Matsumoto T, Inoue K, Kondoh S, Sato T, Takaoka K, Kato S
    • Organizer
      Montreal
    • Place of Presentation
      CANADA
    • Related Report
      2008 Final Research Report
  • [Presentation] 思春期臼蓋形成不全に対する治療法の選択2008

    • Author(s)
      今井祐記
    • Organizer
      日本小児股関節研究会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] International Bone and Mineral Society Davos Workshop Sex Steroids Hormone Mediate Osteoprotecitve Effects by Controlling Osteoclast Life Cycle2008

    • Author(s)
      Imai Y, Nakamura T, Matsumoto T, Sato S, Takeda S, Igarashi K, Yamamoto Y, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S
    • Organizer
      Davos
    • Place of Presentation
      Swiss
    • Related Report
      2008 Final Research Report
  • [Presentation] Multinuclear Expression of ERa in Mature Osteoclasts2008

    • Author(s)
      Youn MY, Takada I, Kondoh S, Imai Y. Kato S
    • Organizer
      ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biochemical Characterization of ERa Co-regulators in Multinucleated Mature Osteoclasts2008

    • Author(s)
      Takada I, Youn MY, Imai Y, Kato S
    • Organizer
      ASBMR Annual Meeting
    • Place of Presentation
      Montreal
    • Related Report
      2008 Annual Research Report
  • [Presentation] Distribution of Sports Activities at the Onset of Hip Joint Disease for Children2008

    • Author(s)
      Kitano T, Morita M, Nakagawa K, Wada M, Imai Y, Eguchi Y
    • Organizer
      APOA
    • Place of Presentation
      Jeju
    • Related Report
      2008 Annual Research Report
  • [Presentation] 閉経後骨粗鬆症の分子基盤解明2007

    • Author(s)
      今井祐記 中村貴 松本高広 竹田秀 高岡邦夫 加藤茂明
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 閉経後骨粗懸症の分子基盤解明2007

    • Author(s)
      今井 祐記 中村 貴 松本 高広 竹田 秀 高岡 邦夫 加藤 茂明
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会)
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] エストロゲンはFasLigndシグナルによる破骨細胞寿命の調節により骨量を維持する2007

    • Author(s)
      今井祐記 中村貴 竹田秀 高岡邦夫 松本高広 加藤茂明
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] エストロゲンはFas Ligndシグナルによる破骨細胞寿命の調節により骨量を維持する2007

    • Author(s)
      今井 祐記 中村 貴 竹田 秀 高岡 邦夫 松本 高広 加藤 茂明
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨折治癒におけるBMPの役割2007

    • Author(s)
      今井祐記 寺井秀富 高岡邦夫
    • Organizer
      日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨折治癒におけるBMPの役割2007

    • Author(s)
      今井 祐記 寺井 秀富 高岡 邦夫
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ASBMR Sex Steroids Hormone Receptors in Osteoclasts Mediate Osteoprotecitve Effects by Regulating Its Life Cycle2007

    • Author(s)
      22Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Shu Takeda, Katsuhide Igarashi, Toru Fukuda, Yoko Yamamoto, Jun Kanno, Kunio Takaoka, Pierre Chambon, Shigeaki Kato
    • Place of Presentation
      Honolulu, USA,
    • Year and Date
      2007-09-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Sex Steroids Hormone Receptors in Osteoclasts Mediate Osteoprotecitve Effects by Regulating Its Life Cycle2007

    • Author(s)
      Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto, Shu Takeda, Katsuhide Igarashi, Toru Fukuda, Yoko Yamamoto, Jun Kanno, Kunio Takaoka, Pierre Chambon, Shigeaki Kato
    • Organizer
      29th ASBMR
    • Place of Presentation
      Honolulu
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bone Biology Forum Estrogen receptor α mediates the osteoprotective estrogen action by controlling the life cycle of osteoclast through Fasligand signaling2007

    • Author(s)
      23Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto and Shigeaki Kato
    • Place of Presentation
      Susono
    • Year and Date
      2007-08-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Estrogen receptor a mediates the osteoprotective estrogen action by controlling the life cycle of osteoclast through Fas ligand signaling2007

    • Author(s)
      Yuuki Imai, Takashi Nakamura, Takahiro Matsumoto and Shigeaki Kato
    • Organizer
      4th Bone Biology Forum
    • Place of Presentation
      Susono
    • Year and Date
      2007-08-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 核内受容体の破骨細胞特異的ノックアウトマウス2007

    • Author(s)
      今井祐記 中村貴 松本高広 加藤茂明
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] エストロゲンの骨量維持機構はFasLigndシグナルを介した破骨細胞寿命の調節である2007

    • Author(s)
      今井祐記 中村貴 竹田秀 福田亨 山本陽子 高岡邦夫 松本高広 加藤茂明
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] エストロゲンの骨量維持機構はFas Ligndシグナルを介した破骨細胞寿命の調節である2007

    • Author(s)
      今井 祐記 中村 貴 竹田 秀 福田 亨 山本 陽子 高岡 邦夫 松本 高広 加藤 茂明
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] 核内受容体の破骨細胞特異的ノックアウトマウス2007

    • Author(s)
      今井 祐記 中村 貴 松本 高広 加藤 茂明
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report
  • [Book] 栄養学研究の最前線2008核内性受容体群による骨代謝制御の分子機構2008

    • Author(s)
      加藤茂明, 高田伊知郎, 中村貴, 山本陽子, 今井祐記
    • Publisher
      建帛社
    • Related Report
      2008 Final Research Report
  • [Book] 栄養学研究の最前線2008

    • Author(s)
      加藤茂明, 高田伊知郎, 中村貴, 山本陽子, 今井祐記
    • Total Pages
      203
    • Publisher
      建帛社
    • Related Report
      2008 Annual Research Report
  • [Remarks] 2009 IBMS-ANZBMS Young Investigator Travelling Award

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008 Young Investigator Travelling Grant Award, International Bone and Mineral Society Davos Workshop

    • Related Report
      2008 Final Research Report
  • [Remarks] 2008日本骨代謝学会IBMS-ANZBMS 2009 Travel Award

    • Related Report
      2008 Final Research Report
  • [Remarks] 2007日本骨代謝学会奨励賞(Encouragement Award)

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.iam.u-tokyo.ac.jp/bnsikato/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/orthoped/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.iam.u-tokyo.ac.jp/bnsikato/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/orthoped/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.iam.u-tokyo.ac.jp/bnsikato/

    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://medwebsv.med.osaka-cu.ac.jp/orthoped/index.html

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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