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Development of therapy against low back pain by inhibition of nerve growth factor

Research Project

Project/Area Number 19791022
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionMie University (2009)
University of Toyama (2007-2008)

Principal Investigator

YUMIKO Asanuma  University of Toyama, 医学部・附属病院, 助教 (10361966)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,740,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords神経成長因子 / 腰痛 / 椎間板性疼痛 / 神経伸長 / 神経仲長 / 間板性疼痛
Research Abstract

NGF expression in the media from cultured intervertebral disc tissues was evaluated at protein level in the patients with low back pain due to intervertebral disc (IVD) disease who underwent spine surgery for spinal canal stenosis (SCS), intervertebral disc herniation (IDH) or trauma. The expression of NGF protein in degenerative disc from SCS was significantly higher than that from normal IVD in both annulus fibrosus (AF) and nucleus pulposus (NP), especially in AF, its expression level was significantly higher in AF than NP. In the IDH samples, the expression of NGF protein was significantly higher than that in the normal IVDs, and the significant difference of NGF expression was not determined between AF and NP from IDH. IDH showed the trend of higher expression of NGF protein level than that of SCS, however the significant difference was not recognized. As a result, it might be possible that in the degenerative disc disease such as SCS, NGF expression from AF may be one of the causes of chronic low back pain, and in IDH patients, NGF expressed in both AF and NP may be the onset of acute low back pain.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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