The effect of Kampo medicine on aging related disease

• Project/Area Number: 19791029
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: KISHIDA Yuki Osaka University, 医学系研究科, 寄附講座助教 (20423163)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,740,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 骨 / 軟骨代謝学 / 漢方薬 / 骨粗鬆症 / 脂質代謝 / 動脈硬化 / 加齢

Research Abstract

Saikokaryukotsuboreito (SRB) is a traditional Japanese herbal medicine. We investigated the effect of SRB on bone metabolism in the postmenopausal period using an ovariectomized (OVX) murine model. We found that SRB can prevent loss of bone volume and suppress serum IL-6 levels in this postmenopausal model and is a promising candidate for treatment of postmenopausal osteoporosis.

Research Products

• [Journal Article] The fixed herbal drug composition "Saikokaryukotsuboreito" prevents bone loss with an association of serum IL-6 reductions in ovariectomized mice model. (2010)
  • Author(s): Hattori T, Fei W, Kizawa T, Nishida S, Yoshikawa H, Kishida Y
  • Journal Title: Phytomedicine 17(3-4) Pages: 170-7
• [Journal Article] The fixed herbal drug composition "Saikokaryukotsuboreito" prevents bone loss with an association of serum IL-6 reductions in ovariectomized mice model. (2010)
  • Author(s): Hattori T
  • Journal Title: Phytomedicine. 17 Pages: 170-177
  • Peer Reviewed
• [Presentation] Saikokaryukotsuboreito, a traditional Japanese herbal medicine, inhibitsbone loss in the postmenopausal period via suppression of interleukin 6 (2010)
  • Author(s): Takako Hattori, Wu Fei, Takuji Kizawa, Kazunari Ozaki, Junsuke Arimitsu, Takaya Inoue, Shinji Nishida, Hideki Yoshikawa, Yuki Kishida
  • Organizer: The 15th International Congress of Oriental Medecine
  • Place of Presentation: Tokyo
  • Year and Date: 2010-02-28
• [Presentation] Saikokaryukotsuboreito, a traditional Japanese herbal medicine, inhibits bone loss in the postmenopausal period via suppression of interleukin 6 (2010)
  • Author(s): Hattori T
  • Organizer: The 15^<th> International Congress of Oriental Medecine
  • Place of Presentation: Tokyo
  • Year and Date: 2010-02-28